FlyBase Allele Report: Dmel\Ssdp[L7]

General Information

Symbol

Dmel\Ssdp^L7

Species

D. melanogaster

Name

FlyBase ID

FBal0147402

Feature type

allele

Associated gene

Dmel\Ssdp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(van Meyel et al., 2003)

Mutagen

Delta2-3 transposase

(van Meyel et al., 2003)

Progenitor genotype

Ssdp^EP3097

(van Meyel et al., 2003)

Cytology

Description

Imprecise excision of P{EP}Ssdp^EP3097 from Ssdp^EP3097 has created a deletion of 3363bp of DNA from the insertion site through the entire coding region of Ssdp plus 941bp of sequence downstream of the 340bp 3' UTR.

(van Meyel et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | larval stage | somatic clone

(Fiedler et al., 2015)

Phenotype Manifest In

denticle field | embryonic stage | maternal effect

(Fiedler et al., 2015)

haltere disc | larval stage | somatic clone

(Fiedler et al., 2015)

scutellar bristle | increased number

(Bronstein et al., 2010)

Detailed Description

Statement

Reference

Haltere disc bearing clones mutant for Ssdp^L7 show severe patterning defects due to clone overgrowth.

Embryos from mothers with Ssdp^L7 mutant germline clones show a lawn of ventral denticles (a hallmark of wg signaling failure).

(Fiedler et al., 2015)

Heterozygotes display duplication of scutellar bristles with <30% penetrance.

(Bronstein et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ssdp^L7/Ssdp[+] is an enhancer of visible phenotype of Chi^e5.5

(van Tienen et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Fer2LCH[+]/Fer2LCH^neo60

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Sam-S[+]/Sams^KG04716

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by CG2767^e02843/CG2767[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Gαs^B19/G-salpha60A[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by CG4080[+]/CG4080^EY01375

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by CG11893^c03576/CG11893[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Spn88Eb^e04451/Spn88Eb[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Mf^EY03476/Mf[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by CtsF^EY02656/CG12163[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by CG12163[+]/CtsF^EY04405

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Cyp6d4[+]/Cyp6d4^EY04319

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, enhanceable by Fer2LCH[+]/Fer2LCH⁰⁰⁰³⁵

(Bronstein et al., 2010)

NOT Enhanced by

Statement

Reference

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by nub^E37/nub[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by eEF5⁰¹²⁹⁶/eIF-5A[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by Hydr2[+]/Hydr2^EY06843

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by CG4080[+]/CG4080^KG08382

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by fbl[+]/fbl¹

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by CG9932^c00144/CG9932[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by Kat60^EY05593/katanin-60[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by CG1518[+]/Stt3A^KG03333

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by Fpps[+]/Fpps^k06103

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by Fpps[+]/Fpps^k03514

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-enhanceable by l(3)mbn^KG02958/l(3)mbn[+]

(Bronstein et al., 2010)

Suppressed by

Statement

Reference

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by pnr[+]/pnr^VX6

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by l(3)mbn^E1/l(3)mbn[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by CG14204[+]/CG14204^EY05761

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by CG2604[+]/CG2604^EY05974

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by Gαs^R60/G-salpha60A[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by tankyrase[+]/Tnks^EP3476

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by CG7755^f06581/CG7755[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, suppressible by Xbp1[+]/Xbp1^k13803

(Bronstein et al., 2010)

NOT suppressed by

Statement

Reference

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by Kat60^EY05593/katanin-60[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by fbl[+]/fbl¹

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by CG9932^c00144/CG9932[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by Fpps[+]/Fpps^k06103

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by Fpps[+]/Fpps^k03514

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by l(3)mbn^KG02958/l(3)mbn[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by CG1518[+]/Stt3A^KG03333

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by nub^E37/nub[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by eEF5⁰¹²⁹⁶/eIF-5A[+]

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by Hydr2[+]/Hydr2^EY06843

(Bronstein et al., 2010)

Ssdp^L7 has scutellar bristle | increased number phenotype, non-suppressible by CG4080[+]/CG4080^KG08382

(Bronstein et al., 2010)

Enhancer of

Statement

Reference

Ssdp^L7/Ssdp[+] is an enhancer of wing phenotype of Chi^e5.5

(van Tienen et al., 2017)

Ssdp^L7/Ssdp[+] is an enhancer of wing margin phenotype of ap^Xa

(Bronstein et al., 2010)

Ssdp^L7/Ssdp[+], Scer\GAL4^ap-md544 is an enhancer of wing phenotype of Chi^{FL.UAS.Tag:MYC}, Scer\GAL4^ap-md544

(van Meyel et al., 2003)

NOT Enhancer of

Statement

Reference

Ssdp^L7 is a non-enhancer of phenotype of Chi^e5.5

(van Meyel et al., 2003)

Suppressor of

Statement

Reference

Ssdp^L7 is a suppressor | partially of wing phenotype of Scer\GAL4^ap-md544, ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC}

(van Meyel et al., 2003)

NOT Suppressor of

Statement

Reference

Ssdp^L7 is a non-suppressor of phenotype of Chi^e5.5

(van Meyel et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The wing notch phenotype seen in Chi^e5.5/+ mutants is exacerbated by the presence of Ssdp^L7/+.

(van Tienen et al., 2017)

The addition of Ssdp^L7 dominantly enhances the wing defects seen in Scer\GAL4^ap-md544, Scer\GAL4^ap-md544 mutants, leaving little or no organised wing tissue. The addition of Ssdp^L7 to ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^ap-md544 animals suppresses the wing blistering phenotype seen in those animals though the wings remain held-up.

(van Meyel et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Ssdp^neo48

(van Meyel et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotypic analysis provides an allelic series: Ssdp^neo48 < Ssdp^EP3097 < Ssdp^EP3004 < Ssdp^L5 = Ssdp^L7.

(van Meyel et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ssdp^L7

ssdp^L7

(van Tienen et al., 2017, Fiedler et al., 2015, Bronstein et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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