FlyBase Allele Report: Dmel\Fpps[k03514]

General Information

Symbol

Dmel\Fpps^k03514

Species

D. melanogaster

Name

FlyBase ID

FBal0118033

Feature type

allele

Associated gene

Dmel\Fpps

Associated Insertion(s)

P{lacW}Fpps^k03514

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Spradling et al., 1999, FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{lacW}Fpps^k03514

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:11,307,524..11,307,524 [+]

(Cook et al., 2012, Spradling et al., 1999, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by SNF4Aγ^loe

(Cook et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Cook et al., 2012)

visible | recessive

(Spradling et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Fpps^k03514 heterozygous mutants do not display a degenerative nervous system phenotype, with only the occasional small vacuole forming in these mutants.

(Cook et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Fpps[+]/Fpps^k03514 is an enhancer of wing margin phenotype of Bx²

(Bronstein et al., 2010)

NOT Enhancer of

Statement

Reference

Fpps[+]/Fpps^k03514 is a non-enhancer of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Suppressor of

Statement

Reference

Fpps[+]/Fpps^k03514 is a suppressor of vacuole phenotype of SNF4Aγ^loe

(Cook et al., 2012)

Fpps[+]/Fpps^k03514 is a suppressor of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

NOT Suppressor of

Statement

Reference

Fpps[+]/Fpps^k03514 is a non-suppressor of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A Fpps^k03514 heterozygous background significantly suppresses the degenerative nervous sytem phenotype found in 5 day old SNF4Aγ^loe mutants. These flies exhibit a reduction in the area of vacuoles in the optic system, from approximately 163 υm[2] to 33υm[2] in a Fpps^k03514/+ background. There is a similar reduction in the number of vacuoles present, confirming an involvement of the isoprenoid pathway in the degenerative phenotype of SNF4Aγ^loe flies.

(Cook et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10532

y¹ w^67c23; raw^k03514 P{lacW}Fpps^k03514/CyO

Notes on Origin

Discoverer

Separable from: raw^k03514.

(FlyBase, 1996-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Fpps^k03514

(Chen et al., 2022)

k03514

(Bronstein et al., 2010)

v(2)k03514

(Spradling et al., 1999)

v(2)k03514^k03514

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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