FlyBase Allele Report: Dmel\Fpps[k06103]

(Jones and Macdonald, 2015, Cook et al., 2012, Santos and Lehmann, 2004, Chung et al., 2001, Beaton, 2000.1.31, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by SNF4Aγ^loe

(Cook et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Cook et al., 2012)

lethal | recessive

(Beaton, 2000.1.31, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

embryonic/larval crystal cell

(Milchanowski et al., 2004)

primordial germ cell

(Santos and Lehmann, 2004)

primordial germ cell | germline clone | rescuable maternal effect

(Santos and Lehmann, 2004)

Detailed Description

Statement

Reference

Fpps^k06103 heterozygous mutants do not display a degenerative nervous system phenotype, with only the occasional small vacuole forming in these mutants.

(Cook et al., 2012)

The average number of crystal cells per embryo is reduced (to 10.5) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average).

(Milchanowski et al., 2004)

In embryos homozygous Fpps^k06103, a small number of germ cells (4 on average) fail to migrate correctly toward the mesoderm and instead remain associated with the dorsal side of the posterior midgut. This phenotype is stronger in embryos both maternally and zygotically homozygous for Fpps^k06103 : 13 germ cells, on average, fail to migrate into the mesoderm.

(Santos and Lehmann, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Fpps[+]/Fpps^k06103 is a suppressor of abnormal neuroanatomy phenotype of SNF4Aγ^loe

(Cook et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Fpps^k06103 has primordial germ cell phenotype, enhanceable by Hmgcr⁰¹¹⁵²

(Santos and Lehmann, 2004)

Fpps^k06103 has primordial germ cell phenotype, enhanceable by qm^L14.4

(Santos and Lehmann, 2004)

Enhancer of

Statement

Reference

Fpps[+]/Fpps^k06103 is an enhancer of wing margin phenotype of Bx²

(Bronstein et al., 2010)

Fpps^k06103 is an enhancer of primordial germ cell phenotype of Hmgcr⁰¹¹⁵²

(Santos and Lehmann, 2004)

Fpps^k06103 is an enhancer of primordial germ cell phenotype of qm^L14.4

(Santos and Lehmann, 2004)

NOT Enhancer of

Statement

Reference

Fpps[+]/Fpps^k06103 is a non-enhancer of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

Fpps[+]/Fpps^k06103 is a non-enhancer of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Suppressor of

Statement

Reference

Fpps[+]/Fpps^k06103 is a suppressor of primordial germ cell | maternal effect | embryonic stage 5 phenotype of Neurl4^Δ1

(Jones and Macdonald, 2015)

NOT Suppressor of

Statement

Reference

Fpps[+]/Fpps^k06103 is a non-suppressor of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

Fpps[+]/Fpps^k06103 is a non-suppressor of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A Fpps^k06103 heterozygous background significantly suppresses the degenerative nervous sytem phenotype found in 5 day old SNF4Aγ^loe mutants. These flies exhibit a reduction in the area of vacuoles in the optic system, from approximately 163 υm[2] to 25υm[2] in a Fpps^k06103/+ background. There is a similar reduction in the number of vacuoles present, confirming an involvement of the isoprenoid pathway in the degenerative phenotype of SNF4Aγ^loe flies.

(Cook et al., 2012)

Germ cell migration is severely defective in Fpps^k06103; qm^L14.4 double homozygous embryos. About 40% of Fpps^k06103; Hmgcr⁰¹¹⁵² double homozygous embryoshave severe patterning defects. However, in the remaining 60% the mesoderm appears correctly patterned but germ cell migration is severely defective (on average 14 germ cells remain on the gut), an enhancement over the germ cell migration phenotype seen in either single mutant.

(Santos and Lehmann, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10604

y¹ w^67c23; P{lacW}Fpps^k06103/CyO

Kyoto

111189

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Fpps^k06103 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Reversion analysis proved that the P{lacW} is responsible for the lethal phenotype.

(Beaton, 2000.1.31)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Fpps^k06103

(Chen et al., 2022, Christensen and Cook, 2007.5.8)

P10604

(Milchanowski et al., 2004)

fpps^K06103

(Jones and Macdonald, 2015)

k06103

(Bronstein et al., 2010)

l(2)k06103

(Spradling et al., 1999)

l(2)k06103^k06103

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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