FlyBase Allele Report: Dmel\ap::Chi[ΔLID.ΔLIM.UAS.Tag:MYC]

General Information

Symbol

Dmel\ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0102809

Feature type

allele

Associated gene

ap::Chi

Associated Insertion(s)

Carried in Construct

P{UAS-ChiΔLID::apΔLIM}

Also Known As

UAS-ChipΔLID:ApΔLIM

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(van Meyel et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-ChiΔLID::apΔLIM}

Cytology

Description

UAS regulatory sequences drive expression of a chimeric protein consisting of a deleted form of Chi (lacking the LIM interaction domain) fused to a deleted form of ap (lacking the LIM domain). The protein is tagged at the C-terminal end with 5 copies of Tag:MYC.

(van Meyel et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

ap::Chi

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Scer\GAL4^ap-md544

(van Meyel et al., 2003)

Detailed Description

Statement

Reference

ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^ap-md544 produces flies that have blistered wings in which the dorsal and ventral surfaces fail to fuse, and which are help upward and away from the thorax.

(van Meyel et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor | partially of visible phenotype of ap^md544/ap^P44

(van Meyel et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ap-md544, ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} has wing phenotype, suppressible | partially by Ssdp^L7

(van Meyel et al., 2003)

Suppressor of

Statement

Reference

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor of pretarsus phenotype of ap^md544/ap^UGO35

(Pueyo and Couso, 2004)

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor of tarsal segment 4 phenotype of ap^md544/ap^UGO35

(Pueyo and Couso, 2004)

ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC}, Scer\GAL4^ap-md544 is a suppressor | partially of tarsal segment 4 phenotype of Bar^UAS.cKa, Scer\GAL4^ap-md544

(Pueyo and Couso, 2004)

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor of embryonic/larval neuron phenotype of Chi^e5.5, ap^md544/ap^P44

(van Meyel et al., 2000)

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor of embryonic/larval neuron phenotype of Chi^e5.5

(van Meyel et al., 2000)

Scer\GAL4^ap-md544/ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC} is a suppressor | partially of wing phenotype of ap^md544/ap^P44

(van Meyel et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of tarsal segment 4 in the legs of B^Scer\UAS.cKa; Scer\GAL4^ap-md544 flies is partially suppressed by ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}. ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}; Scer\GAL4^ap-md544 suppresses fusion of tarsal segments 4 and 5 in ap^UGO35/ap^md544 flies.

(Pueyo and Couso, 2004)

The addition of Ssdp^L7 to ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^ap-md544 animals suppresses the wing blistering phenotype seen in those animals though the wings remain held-up.

(van Meyel et al., 2003)

Rescues pathway recognition and axon fasciculation in a majority of segments in ap^md544/ap^P44 embryos when expressed under the control of Scer\GAL4^ap-md544. Rescues the axon defects seen in Chi^e5.5 embryos when expressed under the control of Scer\GAL4^ap-md544. The axon defects seen in Chi^e5.5 ap^md544/ap^P44 double mutants are completely rescued by ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC} expressed under the control of Scer\GAL4^ap-md544.

(van Meyel et al., 2000)

Partially suppresses the mutant wing phenotype of ap^md544/ap^P44 flies when expressed under the control of Scer\GAL4^ap-md544.

(van Meyel et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ap::Chi^{ΔLID.ΔLIM.Scer\UAS.T:Hsap\MYC}

ap::Chi^{ΔLID.ΔLIM.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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