FlyBase Allele Report: Dmel\nub[E37]

General Information

Symbol

Dmel\nub^E37

Species

D. melanogaster

Name

FlyBase ID

FBal0046195

Feature type

allele

Associated gene

Dmel\nub

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Yeo et al., 1995)

Mutagen

ethyl methanesulfonate

(Yeo et al., 1995)

Progenitor genotype

Cytology

Description

Point mutation.

(Yeo et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage (with Df(2L)GR4)

(Turchyn et al., 2011)

some die during pharate adult stage (with Df(2L)GR4)

(Turchyn et al., 2011)

suppressor of variegation | dominant, with P{SUPor-P}KV00108

(Swenson et al., 2016)

Phenotype Manifest In

ganglion mother cell GMC4-2a

(Yeo et al., 1995)

larval RP2 motor neuron

(Yeo et al., 1995)

metatarsus of male prothoracic leg (with Df(2L)GR4)

(Turchyn et al., 2011)

sex comb | ectopic (with Df(2L)GR4)

(Turchyn et al., 2011)

tarsal segment (with Df(2L)GR4)

(Turchyn et al., 2011)

tibia (with Df(2L)GR4)

(Turchyn et al., 2011)

Detailed Description

Statement

Reference

nub^E37/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

(Swenson et al., 2016)

nub^E37/Df(2L)GR4 flies are able to reach pupal stage but die as pharate adults.

nub^E37/Df(2L)GR4 pharate adults are characterised by the absence of the joints between the coxa, trochanter, femur, and tibia. These mutants also exhibit the loss of tissue proximal to these joints that leads to the appearance of fused leg segments, and in some cases, to the elimination of the entire tarsal subunit. The most visible changes are observed in the tibia and tarsus. The former acquires the sex combs that are normally found at the distal end of the first tarsomere, which correlates with the fusion of Ti and Ta-1. The tarsus also loses the fifth tarsomere (Ta-5) that, in turn, entails the loss of the attached claw. In addition, these mutants have the femur fused to to the proximal end of the tibia.

(Turchyn et al., 2011)

Number of hemisegments with a mature RP2 neuron in homozygous embryos is reduced to 99%. The failure to produce mature RP2 neurons is attributable, at least in part, to GMC4-2a adopting an aberrant cell identity.

(Yeo et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

nub^E37 is a non-suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

nub^E37/nub[+] is an enhancer of wing margin phenotype of Bx²

(Bronstein et al., 2010)

NOT Enhancer of

Statement

Reference

nub^E37/nub[+] is a non-enhancer of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

nub^E37/nub[+] is a non-enhancer of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

NOT Suppressor of

Statement

Reference

nub^E37 is a non-suppressor of wing hinge phenotype of Scer\GAL4^Bx-MS1096, hng1^KK103642

(Shukla et al., 2014)

nub^E37/nub[+] is a non-suppressor of scutellar bristle | increased number phenotype of Chi^e5.5

(Bronstein et al., 2010)

nub^E37/nub[+] is a non-suppressor of scutellar bristle | increased number phenotype of Ssdp^L7

(Bronstein et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A nub^E37 mutant background has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

(Shukla et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8856

nub^E37/CyO, P{ftz-lacB}E3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

nub(E37)

(Shukla et al., 2014)

nub^E37

(Kao et al., 2012, Natori et al., 2012, Turchyn et al., 2011, Bronstein et al., 2010)

nub^e37

(Swenson et al., 2016)

pdm-1^E37

(Yeo et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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