FlyBase Allele Report: Dmel\hng1[KK103642]

General Information

Symbol

Dmel\hng1^KK103642

Species

D. melanogaster

Name

FlyBase ID

FBal0232440

Feature type

allele

Associated gene

Dmel\hng1

Associated Insertion(s)

Carried in Construct

P{KK103642}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK103642}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK103642

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

flightless, with Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

visible, with Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Phenotype Manifest In

wing blade | distal, with Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

wing hinge, with Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

wing hinge, with Scer\GAL4^da.PU

(Shukla et al., 2014)

Detailed Description

Statement

Reference

Expression of hng1^KK103642 under the control of Scer\GAL4^Bx-MS1096 leads to wing hinge defects in the adult fly. Defects include a reduced/mispatterned alula, a bent hinge, and a disorganized costa region. The flies cannot fold its wings over the abdomen normally, and has a "held out" wing phenotype. The animals can flap their wings but cannot fly. Wings are smaller than in controls. The phenotype is 100% penetrant and dose dependent, with increased knockdown leading to a stronger phenotype that also affects the more distal wing blade. Hinge defects are also seen when hng1^KK103642 is expressed ubiquitously under the control of Scer\GAL4^da.PU.

(Shukla et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by Df(2R)BSC484/+

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by hth^{UAS.Tag:MYC.cSa}/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by hng2^KK103584/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by jing^UAS.cCa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by dpp^HMS00011/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by mirr^JF02196/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by Dlip3^KK111529, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by Coop^GD6554, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has abnormal size phenotype, enhanceable by hng2^KK103584/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by brwl^KK112405/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by CG11723^GD7373, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by CG4404^GD16746, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by Dlip3^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by Ctps^GD4740, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by stwl^KK105453/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, enhanceable by hng3^KK111648/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has abnormal size phenotype, enhanceable by hng3^KK111648/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-enhanceable by tio^HMS01527/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-enhanceable by Adf1^GD1358, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-enhanceable by CG8119^NIG.8119R, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-enhanceable by CG13204^NIG.13204R, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible by tsh^HMS01443/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible | partially by hth^JF02733/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible by jing^JF02345/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible by wg^spd-fg/wg[+]

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible | partially by CG11723^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, suppressible | partially by CG13204^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-suppressible by vg¹

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-suppressible by nub^E37

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-suppressible by rn^UAS.cSPa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has visible phenotype, non-suppressible by mirr^JF02196/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by hng2^KK103584/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, enhanceable by hng2^KK103584/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by hth^{UAS.Tag:MYC.cSa}/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by hth^{UAS.Tag:MYC.cSa}/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, enhanceable by hth^{UAS.Tag:MYC.cSa}/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by jing^UAS.cCa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by jing^UAS.cCa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, enhanceable by jing^UAS.cCa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by dpp^HMS00011/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by mirr^JF02196/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by Dlip3^KK111529, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by Coop^GD6554, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by brwl^KK112405/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by CG11723^GD7373, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by CG4404^GD16746, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by hng3^KK111648/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by Dlip3^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by Ctps^GD4740, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, enhanceable by stwl^KK105453/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, enhanceable by hng3^KK111648/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, enhanceable by Df(2R)BSC484/+

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, enhanceable by Df(2R)BSC484/+

(Shukla et al., 2014)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, non-enhanceable by tio^HMS01527/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, non-enhanceable by tio^HMS01527/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-enhanceable by Adf1^GD1358, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-enhanceable by CG8119^NIG.8119R, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-enhanceable by CG13204^NIG.13204R, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, suppressible by tsh^HMS01443/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible | partially by hth^JF02733/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, suppressible | partially by hth^JF02733/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, suppressible | partially by hth^JF02733/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible by jing^JF02345/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, suppressible by jing^JF02345/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has alula phenotype, suppressible by jing^JF02345/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible by wg^spd-fg/wg[+]

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible | partially by CG11723^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible | partially by CG13204^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, suppressible by tsh^HMS01443/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing phenotype, suppressible by tsh^HMS01443/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-suppressible by vg¹

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-suppressible by nub^E37

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-suppressible by rn^UAS.cSPa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Scer\GAL4^Bx-MS1096, hng1^KK103642 has wing hinge phenotype, non-suppressible by mirr^JF02196/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of hng2^KK103584 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of hng3^KK111648 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of hng1^KK103642 under the control of Scer\GAL4^Bx-MS1096 enhances the wing hinge phenotypes seen in Df(2R)BSC306/+ mutant flies.

Expression of hng1^KK103642 under the control of Scer\GAL4^Bx-MS1096 enhances the wing hinge phenotypes seen in Df(2R)BSC484/+ mutant flies.

One copy of Df(2R)BSC484 enhances the wing phenotypes seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of tio^HMS01527 has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of tsh^HMS01443 suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also rescued.

Expression of hth^JF02733 suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also rescued.

Expression of hth^{Scer\UAS.T:Hsap\MYC.cSa} enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of jing^JF02345 suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also rescued.

Expression of jing^Scer\UAS.cCa enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

One copy of wg^spd-fg suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. No changes in cellular proliferation are detected in these animals.

A vg¹ mutant background has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

A nub^E37 mutant background has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expressing rn^{Scer\UAS.cSPa} has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expressing dpp^HMS00011 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expressing mirr^JF02196 has no effect on the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of Dip3^KK111529 enhances the wing phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of Coop^GD6554 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG3838^KK112405 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG11723^JF02511 enhances the wing phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG4404^GD16746 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of Adf1^GD1358 does not enhance the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG8119^NIG.8119R does not enhance the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG30403^GD8859 does not enhance the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG13204^NIG.13204R does not enhance the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CG11723^{Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG} suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also partially rescued.

Expression of CG13204^{Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG} partially suppresses the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096. The size and patterning of the alula is also partially rescued.

Expression of Dip3^{Scer\UAS.T:Ivir\HA1,T:Zzzz\FLAG} enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of CTPsyn^GD4740 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

Expression of stwl^KK105453 enhances the wing hinge phenotype seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

(Shukla et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

hng1^KK103642 is rescued by hng1^UASp.cSa/Scer\GAL4^Bx-MS1096

(Shukla et al., 2014)

Comments

Expression of hng1^{Scer\UAS.P\T.cSa} significantly rescues the wing hinge defects seen when hng1^KK103642 is expressed under the control of Scer\GAL4^Bx-MS1096.

(Shukla et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100101

P{KK103642}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG9437^KK103642

hng1^KK103642

Name Synonyms

Secondary FlyBase IDs

References (2)

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