FlyBase Allele Report: Dmel\peb[308]

General Information

Symbol

Dmel\peb³⁰⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0126346

Feature type

allele

Associated gene

Dmel\peb

Associated Insertion(s)

P{hsp70-boss}peb³⁰⁸

Carried in Construct

Also Known As

hnt³⁰⁸

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Reed et al., 2001)

Progenitor genotype

boss^hs.P

(Reed et al., 2001)

Associated Insertion(s)

P{hsp70-boss}peb³⁰⁸

Cytology

Description

The P{hsp70-boss} insertion is located 509bp upstream of the peb cDNA NB701, with the 5' of the element closest to the peb exon.

(Reed et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{hsp70-boss}

enhancer trap

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:4,617,338..4,617,338 [+]

(Reed et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | partially | recessive

(Wilk et al., 2004, Reed et al., 2001)

some die during embryonic stage | recessive

(Wilk et al., 2004, Reed et al., 2001)

Phenotype Manifest In

embryonic/first instar larval cuticle | dorsal

(Reed et al., 2001)

mitotic domain 1 | extended germ band stage

(Reed et al., 2001)

Detailed Description

Statement

Reference

peb³⁰⁸ mutants exhibit 41% embryonic lethality. 19.6% of embryos exhibit a germband retraction phenotype, 65.6% a dorsal closure phenotype.

(Reed et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by chic[+]/chic²²¹

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by kst[+]/kst⁰¹³¹⁸

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by vkg[+]/vkg^k00236

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by vkg[+]/vkg^k07138

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by vkg[+]/vkg^k16721

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, enhanceable by dpp^P23

(Reed et al., 2001)

NOT Enhanced by

Statement

Reference

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by puc¹/puc[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by puc^A251.1F3/puc[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by slbo^ry8/slbo[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by vkg[+]/vkg^k16502

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by Rho1^k07236/Rho1[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by chic[+]/chic⁰¹³²⁰

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by heix^k11403/heix[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by kst[+]/kst¹

(Wilk et al., 2004)

peb³⁰⁸ has lethal | embryonic stage | recessive | partially phenotype, non-enhanceable by kst[+]/kst²

(Wilk et al., 2004)

Suppressed by

Statement

Reference

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by Cg25C[+]/Col4a1^k00405

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by Df(3L)kto2/+

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by Delta⁰⁵¹⁵¹/Dl[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by LanA^3A1/LanA[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by LanA^4A8/LanA[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by tkv^k16713/tkv[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by tutl^k14703/tutl[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by vkg[+]/vkg⁰¹²⁰⁹

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by vkg¹⁷⁷/vkg[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by Rho1^J3.8/Rho1[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by Cg25C[+]/Col4a1²³⁴

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by bsk^J27

(Reed et al., 2001)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by dpp¹⁰⁶³⁸

(Reed et al., 2001)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, suppressible by bsk¹

(Reed et al., 2001)

NOT suppressed by

Statement

Reference

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by Rho1^k07236/Rho1[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by chic[+]/chic⁰¹³²⁰

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by heix^k11403/heix[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by kst[+]/kst¹

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by kst[+]/kst²

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by puc¹/puc[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by puc^A251.1F3/puc[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by slbo^ry8/slbo[+]

(Wilk et al., 2004)

peb³⁰⁸ has lethal | recessive | partially | embryonic stage phenotype, non-suppressible by vkg[+]/vkg^k16502

(Wilk et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

peb³⁰⁸ has embryonic/first instar larval cuticle | dorsal phenotype, enhanceable by dpp^P23

(Reed et al., 2001)

peb³⁰⁸ has mitotic domain 1 | extended germ band stage phenotype, enhanceable by dpp^P23

(Reed et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of bsk^J27 or bsk¹ suppresses the lethality phenotype seen in peb³⁰⁸ embryos, leading to 29% and 18% lethality respectively. The addition of dpp¹⁰⁶³⁸ suppresses the lethality phenotype seen in peb³⁰⁸ embryos, leading to 5% lethality. The addition of dpp^P23 enhances the phenotypes seen in peb³⁰⁸ embryos, leading to 80% lethality, 40.5% of embryos exhibiting a germband retraction phenotype, and 50.2% a dorsal closure phenotype.

(Reed et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hnt³⁰⁸

(Ng et al., 2020, Wilk et al., 2004, Wilk et al., 2004, Reed et al., 2001)

peb³⁰⁸

(Ríos-Barrera et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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