FlyBase Allele Report: Dmel\Rho1[k07236]

General Information

Symbol

Dmel\Rho1^k07236

Species

D. melanogaster

Name

FlyBase ID

FBal0061657

Feature type

allele

Associated gene

Dmel\Rho1

Associated Insertion(s)

P{lacW}Rho1^k07236

Carried in Construct

Also Known As

Rho1^l(2)k07236, RhoA^P1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Strutt et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}Rho1^k07236

Cytology

Description

P{lacW} is inserted into an intron 33bp upstream of the Rho1 ATG.

(Magie et al., 1999)

Insertion of a P{lacW} element, within an intron.

(Strutt et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,103,586..16,103,586 [+]

(van Impel et al., 2009, Hu et al., 2001, Magie et al., 1999, Spradling, 1999.12.9, Spradling et al., 1999, Strutt et al., 1997, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Strutt et al., 1997)

lethal - all die during embryonic stage | recessive

(Magie et al., 1999)

some die during embryonic stage | recessive

(Magie et al., 1999)

visible | recessive

(Spradling, 1999.12.9)

Phenotype Manifest In

eye

(Spradling, 1999.12.9)

Detailed Description

Statement

Reference

Strong allele.

(Magie et al., 1999)

No obvious phenotype.

(Spradling et al., 1999)

Rho1^k07236/Df(2R)Jp1 flies show a very weak eye phenotype.

(Spradling, 1999.12.9)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Rho1^k07236/Rho1[+] is a non-enhancer of lethal | embryonic stage | recessive | partially phenotype of peb³⁰⁸

(Wilk et al., 2004)

Suppressor of

Statement

Reference

Rho1^k07236/Rho1[+] is a suppressor of lethal | pharate adult stage | temperature conditional phenotype of Scer\GAL4^GMR.PU, pbl^{ΔN-term.UAS.Tag:HA}

(van Impel et al., 2009)

Rho1^k07236/Rho1[+] is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, pbl^{DH-PH.UAS.Tag:HA}

(van Impel et al., 2009)

Rho1^k07236 is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

NOT Suppressor of

Statement

Reference

Rho1^k07236/Rho1[+] is a non-suppressor of lethal | recessive | partially | embryonic stage phenotype of peb³⁰⁸

(Wilk et al., 2004)

Other

Statement

Reference

Rho1^k07236/Rho1[+], Scer\GAL4^GMR.PU, pbl^{ΔN-term.UAS.Tag:HA} has visible | adult stage | temperature conditional phenotype

(van Impel et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rho1^k07236/Rho1[+] is a suppressor of eye | adult stage phenotype of Scer\GAL4^GMR.PU, pbl^{DH-PH.UAS.Tag:HA}

(van Impel et al., 2009)

Rho1^k07236/Rho1[+] is a suppressor of wing vein L3 phenotype of Moe^C858

(Molnar and de Celis, 2006)

Rho1^k07236/Rho1[+] is a suppressor of wing phenotype of Moe^C858

(Molnar and de Celis, 2006)

Rho1^k07236 is a suppressor of larval VL3/4 motor neuron phenotype of PlexB^UAS.cHa, Scer\GAL4^elav.PLu

(Hu et al., 2001)

Rho1^k07236 is a suppressor of larval intersegmental nerve phenotype of PlexB^UAS.cHa, Scer\GAL4^elav.PLu

(Hu et al., 2001)

Rho1^k07236 is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

Other

Statement

Reference

Rho1^k07236/Rho1[+], Scer\GAL4^GMR.PU, pbl^{ΔN-term.UAS.Tag:HA} has eye | adult stage | temperature conditional phenotype

(van Impel et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Rho1^k07236 suppresses the lethality seen when pbl^{ΔN-term.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Rho1^k07236 suppresses the rough eye phenotype seen when pbl^{DH-PH.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

(van Impel et al., 2009)

The more severe wing defects seen in Moe^c858 homozygotes (veination defects and the formation of vesicles between the dorsal and ventral wing surfaces) are suppressed by Rho1^k07236/+.

(Molnar and de Celis, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rho1^k02107b

(Magie et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a separable lethal.

(Spradling, 1999.12.9)

Comments

Excision of the P{lacW} element reverts the lethal phenotype.

(Strutt et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Rho1^k07236

Rho1^l(2)k07236

(Magie et al., 1999)

Rho^l(2)k07236

(Hu et al., 2001)

RhoA^P1

(Strutt et al., 1997)

RhoA^k07236

(Wilk et al., 2004)

l(2)k07236

(Strutt et al., 1997)

n(2)k07236

(Spradling, 1999.12.9, Spradling et al., 1999)

rhoA^P1

(Molnar and de Celis, 2006)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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