FlyBase Allele Report: Dmel\qvr[1]

General Information

Symbol

Dmel\qvr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0121566

Feature type

allele

Associated gene

Dmel\qvr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutation resulting in altered splicing of intron 6 of qvr. A single base change in the intron is likely to be responsible for this defective splicing.

(Koh et al., 2008)

Nucleotide substitution: G?A.

(Koh et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

qvr¹ mutant flies display significantly increased wing beat frequency with a relatively normal DLM firing rate.

(Iyengar and Wu, 2014)

qvr^EY04063/qvr¹ flies show ether-induced leg shaking.

qvr¹ homozygotes and qvr^EY04063/qvr¹ flies show a significant decrease in sleep relative to wild-type controls.

(Koh et al., 2008)

Flies show leg shaking behavior. When exposed to 10mM paraquat for 48hr, mutants show 42% survival (wild type shows 97% survival). qvr¹ mutants do not cause any alteration in amplitude, time course or frequency of MEJPs. At Ca²⁺ concentrations of 0.5mM and 1.0mM the EJC amplitudes do not follow fourth power relationships, indicating that defective K⁺ currents could weaken membrane repolarization and cause transmitter release approaching saturation level at relative lower concentrations. The Ca²⁺ current in larval muscle is not affected by qvr¹. The Ca²⁺ activated K⁺ currents are also unaffected. I_K is also unaffected but I_A is greatly reduced in amplitude and the kinetics of I_A are altered so that the time to peak I_A lengthened.

(Wang et al., 2000)

Homozygous and hemizygous adults are hypersensitive to paraquat. Homozygous adults show severe leg shaking, antennal twitching, abdomen pulsations, wing movement and body shuddering under ether anaesthesia. Homozygous adults have a reduced lifespan compared to wild-type flies.

(Humphreys et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

qvr¹ has visible phenotype, enhanceable by Hk²

(Wang et al., 2000)

qvr¹ has chemical sensitive phenotype, enhanceable by Sh⁵

(Wang et al., 2000)

qvr¹ has increased rate of movement phenotype, enhanceable by Sh⁵

(Wang et al., 2000)

qvr¹ has increased rate of movement phenotype, enhanceable by eag^4PM

(Wang et al., 2000)

qvr¹ has visible phenotype, enhanceable by eag^4PM

(Wang et al., 2000)

qvr¹ has chemical sensitive phenotype, enhanceable by Hk¹

(Wang et al., 2000)

qvr¹ has chemical sensitive phenotype, enhanceable by eag¹

(Wang et al., 2000)

qvr¹ has visible phenotype, enhanceable by Hk¹

(Wang et al., 2000)

qvr¹ has increased rate of movement phenotype, enhanceable by Sh²¹

(Wang et al., 2000)

qvr¹ has visible phenotype, enhanceable by eag¹

(Wang et al., 2000)

qvr¹ has increased rate of movement phenotype, enhanceable by Sh¹⁶

(Wang et al., 2000)

NOT Enhanced by

Statement

Reference

qvr¹ has visible phenotype, non-enhanceable by Sh⁵

(Wang et al., 2000)

qvr¹ has visible phenotype, non-enhanceable by Sh²¹

(Wang et al., 2000)

qvr¹ has visible phenotype, non-enhanceable by Sh¹⁶

(Wang et al., 2000)

Enhancer of

Statement

Reference

qvr¹ is an enhancer of chemical sensitive phenotype of eag¹

(Wang et al., 2000)

qvr¹ is an enhancer of visible phenotype of eag¹

(Wang et al., 2000)

qvr¹ is an enhancer of visible phenotype of Hk²

(Wang et al., 2000)

qvr¹ is an enhancer of increased rate of movement phenotype of Sh⁵

(Wang et al., 2000)

qvr¹ is an enhancer of chemical sensitive phenotype of Sh⁵

(Wang et al., 2000)

qvr¹ is an enhancer of increased rate of movement phenotype of eag^4PM

(Wang et al., 2000)

qvr¹ is an enhancer of visible phenotype of eag^4PM

(Wang et al., 2000)

qvr¹ is an enhancer of chemical sensitive phenotype of Hk¹

(Wang et al., 2000)

qvr¹ is an enhancer of visible phenotype of Hk¹

(Wang et al., 2000)

qvr¹ is an enhancer of increased rate of movement phenotype of Sh²¹

(Wang et al., 2000)

qvr¹ is an enhancer of increased rate of movement phenotype of Sh¹⁶

(Wang et al., 2000)

NOT Enhancer of

Statement

Reference

qvr¹ is a non-enhancer of visible phenotype of Sh⁵

(Wang et al., 2000)

qvr¹ is a non-enhancer of visible phenotype of Sh²¹

(Wang et al., 2000)

qvr¹ is a non-enhancer of visible phenotype of Sh¹⁶

(Wang et al., 2000)

Other

Statement

Reference

Sod1ⁿ¹, qvr¹ has lethal | recessive | pupal stage phenotype

(Humphreys et al., 1996)

Sod1ⁿ¹, qvr¹ has lethal | dominant | pupal stage phenotype

(Humphreys et al., 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

qvr¹ has wing phenotype, enhanceable by Hk²

(Wang et al., 2000)

qvr¹ has wing phenotype, enhanceable by eag^4PM

(Wang et al., 2000)

qvr¹ has wing phenotype, enhanceable by Hk¹

(Wang et al., 2000)

qvr¹ has wing phenotype, enhanceable by eag¹

(Wang et al., 2000)

Enhancer of

Statement

Reference

qvr¹ is an enhancer of wing phenotype of Hk²

(Wang et al., 2000)

qvr¹ is an enhancer of wing phenotype of eag¹

(Wang et al., 2000)

qvr¹ is an enhancer of wing phenotype of eag^4PM

(Wang et al., 2000)

qvr¹ is an enhancer of wing phenotype of Hk¹

(Wang et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

100% of eag¹, qvr¹ double mutants hold their wings down, similar to those of eag,Sh double mutants. 10% of Hk¹, qvr¹ double mutants and 13% of eag^4PM, qvr¹ double mutants show the wings down phenotype. Sequence of potency for causing the wings down phenotype is eag¹ > eag^4PM > Hk¹ > Hk². No wings down phenotype was observed for qvr¹ in combination with Sh²¹, Sh⁵ or Sh¹⁶ though leg shaking is more vigorous in these double mutants than in either of the Sh of qvr single mutants alone. Frequency and amplitude of spontaneous EJPs is dramatically enhanced in qvr¹, eag^4PM double mutants. At external Ca²⁺ concentration of 0.4mM, the increase in EJC amplitude caused by qvr¹ is no greater than that caused by Sh¹⁶, and is not enhanced by Sh¹⁶.

(Wang et al., 2000)

qvr¹/+ ; Sodⁿ¹/Sodⁿ¹ and qvr¹/qvr¹ ; Sodⁿ¹/Sodⁿ¹ animals die as late pupae.

(Humphreys et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

qvr^EY04063

(Koh et al., 2008)

Comments

Complementation assayed with respect to leg shaking behavioral phenotype.

(Wang et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

2-F63

(Humphreys et al., 1996)

qvr

(Koh et al., 2008)

qvr¹

(Ruan et al., 2017, Iyengar and Wu, 2014)

qvr^2-F63

Name Synonyms

Secondary FlyBase IDs

FBal0062496

References (5)

Report Sections

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