FlyBase Allele Report: Dmel\Hk[2]

General Information

Symbol

Dmel\Hk²

Species

D. melanogaster

Name

FlyBase ID

FBal0005497

Feature type

allele

Associated gene

Dmel\Hk

Associated Insertion(s)

Carried in Construct

Also Known As

Hk^2T

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kerscher et al., 1995, Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

abnormal sleep

(Bushey et al., 2010)

fertile

(Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

increased rate of movement

(Bushey et al., 2010)

short lived

(Bushey et al., 2010)

uncoordinated

(Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

viable

(Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hk² mutants exhibit a short-sleeping phenotype after day 16, peaking at day 32 and persisting until day 95.

Hk² flies are consistently hyperactive for at least half of their life. Old Hk² flies still sleep less than controls but show less hyperactivity.

Hk² flies exhibit an approximate 13% decrease in life-span compared to wild-type.

(Bushey et al., 2010)

RK1 Following etherisation legs vibrate rapidly. Non-etherised flies respond to hand moving above the vial by falling about as if completely uncoordinated.

(Pasternak and Kaplan, 1968)

RK1 Non-etherised flies respond to hand moving above the vial by falling about as if uncoordinated.

(Trout and Kaplan, 1968)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hk² has visible phenotype, enhanceable by qvr¹

(Wang et al., 2000)

Enhancer of

Statement

Reference

Hk² is an enhancer of visible phenotype of qvr¹

(Wang et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hk² has wing phenotype, enhanceable by qvr¹

(Wang et al., 2000)

Enhancer of

Statement

Reference

Hk² is an enhancer of wing phenotype of qvr¹

(Wang et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

< 10% of Hk², qvr¹ double mutants show the wings down phenotype.

(Wang et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

Hk²

Kyoto

105701

Hk²

Notes on Origin

Discoverer

Trout.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hk²

(Agrawal et al., 2017, Bushey et al., 2010, Popodi et al., 2010-)

Hk^2T

(Pasternak and Kaplan, 1968, Trout and Kaplan, 1968)

hyperkinetic²

(Axelrod et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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