FlyBase Allele Report: Dmel\grim[GMR.PH]

General Information

Symbol

Dmel\grim^GMR.PH

Species

D. melanogaster

Name

glass multimer reporter construct of Hawkins

FlyBase ID

FBal0119243

Feature type

allele

Associated gene

Dmel\grim

Associated Insertion(s)

Carried in Construct

P{GMR-grim.H}

Also Known As

GMR-Grim

Key Links

Transgenic product class

wild_type

(Hawkins et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Hawkins et al., 2000)

Mutagen

in vitro construct

(Hawkins et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-grim.H}

Cytology

Description

GMR regulatory sequences drive expression of grim.

(Hawkins et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

grim

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Vernooy et al., 2002)

visible

(Ribaya et al., 2009, Tiwari and Roy, 2009, Arya and Lakhotia, 2008, Copeland et al., 2007, Guo et al., 2003, Hawkins et al., 2000)

Phenotype Manifest In

eye

(Mallik and Lakhotia, 2009, Ribaya et al., 2009, Tiwari and Roy, 2009, Arya and Lakhotia, 2008, Copeland et al., 2007, Muro et al., 2006, Guo et al., 2003, Vernooy et al., 2002, Hawkins et al., 2000)

Detailed Description

Statement

Reference

Eyes are highly ablated and abnormally shaped.

(Mallik and Lakhotia, 2009)

Flies expressing grim^GMR.PH have smaller eyes than normal.

(Ribaya et al., 2009)

Flies that express grim^GMR.PH have small eyes.

(Muro et al., 2006)

Flies expressing grim^GMR.PH have a small eye phenotype.

(Guo et al., 2003)

Expression of grim^GMR.PH results in a small eye phenotype.

(Hawkins et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

grim^GMR.PH has visible phenotype, enhanceable by Rab11^mo

(Tiwari and Roy, 2009)

grim^GMR.PH has increased cell death phenotype, enhanceable by Bruce^E12

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, enhanceable by Bruce^E16

(Vernooy et al., 2002)

NOT Enhanced by

Statement

Reference

grim^GMR.PH has visible phenotype, non-enhanceable by ec^SF1.GMR

(Copeland et al., 2007)

grim^GMR.PH has visible phenotype, non-enhanceable by ec^EPΔ4

(Copeland et al., 2007)

grim^GMR.PH has increased cell death phenotype, non-enhanceable by Bruce^BIR.GMR

(Vernooy et al., 2002)

Suppressed by

Statement

Reference

grim^GMR.PH has visible phenotype, suppressible by scny^D.GMR

(Ribaya et al., 2009)

grim^GMR.PH has visible phenotype, suppressible by Hsp60D^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Arya and Lakhotia, 2008)

grim^GMR.PH has increased cell death phenotype, suppressible by Bruce^GMREP-86a-2

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, suppressible by Bruce^GMREP-86a-3

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, suppressible by Bruce^GMREP-86a-4

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, suppressible by Bruce^GMREP-86a-5

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, suppressible by Bruce^GMREP-86a-1

(Vernooy et al., 2002)

grim^GMR.PH has visible phenotype, suppressible by Dronc^C318S.GMR

(Hawkins et al., 2000)

NOT suppressed by

Statement

Reference

grim^GMR.PH has visible phenotype, non-suppressible by ec^EPΔ4

(Copeland et al., 2007)

grim^GMR.PH has visible phenotype, non-suppressible by ec^SF1.GMR

(Copeland et al., 2007)

grim^GMR.PH has visible phenotype, non-suppressible by Psn^C1/Psn[+]

(Guo et al., 2003)

grim^GMR.PH has visible phenotype, non-suppressible by Psn^D278A.GMR

(Guo et al., 2003)

grim^GMR.PH has visible phenotype, non-suppressible by nct[+]/Nct^J2

(Guo et al., 2003)

FBal0366230:, grim^GMR.PH has visible phenotype, non-suppressible by Nct^{RNAi.291-696.GMR}/Nct^{RNAi.291-696.GMR}

(Guo et al., 2003)

FBal0366231:, grim^GMR.PH has visible phenotype, non-suppressible by aph-1^{RNAi.29-174.GMR}/aph-1^{RNAi.29-174.GMR}

(Guo et al., 2003)

grim^GMR.PH has visible phenotype, non-suppressible by Df(2L)1567/+

(Guo et al., 2003)

grim^GMR.PH has increased cell death phenotype, non-suppressible by Bruce^BIR.GMR

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, non-suppressible by P{EP}stich1^EP359

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, non-suppressible by jumu^06142a

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, non-suppressible by jumu⁰⁶⁴³⁹

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, non-suppressible by jumu^EP739

(Vernooy et al., 2002)

grim^GMR.PH has increased cell death phenotype, non-suppressible by l(3)j8B6^j8B6

(Vernooy et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

grim^GMR.PH has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

grim^GMR.PH has eye phenotype, enhanceable by Diap1^RNAi.UAS.cLa/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

grim^GMR.PH has eye phenotype, enhanceable by Rab11^mo

(Tiwari and Roy, 2009)

grim^GMR.PH has eye phenotype, enhanceable by Bruce^E12

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, enhanceable by Bruce^E16

(Vernooy et al., 2002)

NOT Enhanced by

Statement

Reference

grim^GMR.PH has eye phenotype, non-enhanceable by ec^SF1.GMR

(Copeland et al., 2007)

grim^GMR.PH has eye phenotype, non-enhanceable by ec^EPΔ4

(Copeland et al., 2007)

grim^GMR.PH has eye phenotype, non-enhanceable by Bruce^BIR.GMR

(Vernooy et al., 2002)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, grim^GMR.PH, lncRNA:Hsrω^EP3037 has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

grim^GMR.PH has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

grim^GMR.PH has eye phenotype, suppressible by scny^D.GMR

(Ribaya et al., 2009)

grim^GMR.PH has eye phenotype, suppressible by Hsp60D^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Arya and Lakhotia, 2008)

grim^GMR.PH has eye phenotype, suppressible by Drice^Δ1/Drice^Δ1

(Muro et al., 2006)

grim^GMR.PH has eye phenotype, suppressible by Dronc¹¹/Nc[+]

(Waldhuber et al., 2005)

grim^GMR.PH has eye phenotype, suppressible by Dronc⁵¹/Nc[+]

(Waldhuber et al., 2005)

grim^GMR.PH has eye phenotype, suppressible by Dronc³⁰/Nc[+]

(Waldhuber et al., 2005)

grim^GMR.PH has eye phenotype, suppressible by mir-14^GMR.PX

(Xu et al., 2003)

grim^GMR.PH has eye phenotype, suppressible by Bruce^GMREP-86a-1

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, suppressible by Bruce^GMREP-86a-2

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, suppressible by Bruce^GMREP-86a-3

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, suppressible by Bruce^GMREP-86a-4

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, suppressible by Bruce^GMREP-86a-5

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, suppressible by Dronc^C318S.GMR

(Hawkins et al., 2000)

NOT suppressed by

Statement

Reference

Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF, grim^GMR.PH has eye phenotype, non-suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

grim^GMR.PH has eye phenotype, non-suppressible by ec^EPΔ4

(Copeland et al., 2007)

grim^GMR.PH has eye phenotype, non-suppressible by ec^SF1.GMR

(Copeland et al., 2007)

grim^GMR.PH has eye phenotype, non-suppressible by Psn^C1/Psn[+]

(Guo et al., 2003)

grim^GMR.PH has eye phenotype, non-suppressible by Psn^D278A.GMR

(Guo et al., 2003)

grim^GMR.PH has eye phenotype, non-suppressible by nct[+]/Nct^J2

(Guo et al., 2003)

FBal0366230:, grim^GMR.PH has eye phenotype, non-suppressible by Nct^{RNAi.291-696.GMR}/Nct^{RNAi.291-696.GMR}

(Guo et al., 2003)

FBal0366231:, grim^GMR.PH has eye phenotype, non-suppressible by aph-1^{RNAi.29-174.GMR}/aph-1^{RNAi.29-174.GMR}

(Guo et al., 2003)

grim^GMR.PH has eye phenotype, non-suppressible by Df(2L)1567/+

(Guo et al., 2003)

grim^GMR.PH has eye phenotype, non-suppressible by jumu⁰⁶⁴³⁹

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, non-suppressible by jumu^EP739

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, non-suppressible by l(3)j8B6^j8B6

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, non-suppressible by Bruce^BIR.GMR

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, non-suppressible by P{EP}stich1^EP359

(Vernooy et al., 2002)

grim^GMR.PH has eye phenotype, non-suppressible by jumu^06142a

(Vernooy et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^GMR.PF-mediated expression of P{Sym-UAS-Hsrω} significantly rescues the grim^GMR.PH eye phenotype.

Scer\GAL4^GMR.PF-mediated expression of Hsrω^EP3037 significantly enhances the grim^GMR.PH eye phenotype.

Scer\GAL4^GMR.PF-mediated expression of P{Sym-UAS-Hsrω} eliminates the enhancing effect of Hsrω^EP3037 on grim^GMR.PH eyes as well as reversing the level of degeneration seen in eyes expressing grim^GMR.PH alone.

Expression of th^{dsRNA.Scer\UAS.cLa} using Scer\GAL4^GMR.PF enhances the grim^GMR.PH small eye phenotype.

Co-expression of P{Sym-UAS-Hsrω} fails to suppress the eye damage in the grim^GMR.PH, th^{dsRNA.Scer\UAS.cLa}, Scer\GAL4^GMR.PF background.

(Mallik and Lakhotia, 2009)

The small eye phenotype exhibited by flies expressing grim^GMR.PH is suppressed in a Ice^Δ1 homozygous background.

(Muro et al., 2006)

The rough, small eye phenotype of grim^GMR.PH is partially suppressed by Nc¹¹/+, Nc⁵¹/+ or Nc³⁰/+.

(Waldhuber et al., 2005)

Psn^C1/+ or Nct^J2/+ does not suppress the small eye phenotype caused by expression of grim^GMR.PH.

Psn^D278A.GMR does not suppress the small eye phenotype caused by expression of grim^GMR.PH.

Expression of Nct^{dsRNA.291-696.GMR} does not suppress the small eye phenotype caused by expression of grim^GMR.PH.

Expression of aph-1^{dsRNA.29-174.GMR} does not suppress the small eye phenotype caused by expression of grim^GMR.PH.

(Guo et al., 2003)

When one of Bruce^GMREP-86a-1, Bruce^GMREP-86a-2, Bruce^GMREP-86a-3, Bruce^GMREP-86a-4 or Bruce^GMREP-86a-5 is added to grim^GMR.PH, its cell death phenotype in the eye is suppressed. The addition of jumu^EP739, jumu^06142a, jumu⁰⁶⁴³⁹, l(3)j8B6^j8B6 or P{EP}stich1^EP359 has no effect. The addition of Bruce^E16 or Bruce^E12 enhances the cell death phenotype in the eye seen in grim^GMR.PH animals alone. The addition of Bruce^BIR.GMR has no effect on the cell death phenotype in the eye seen in grim^GMR.PH animals alone.

(Vernooy et al., 2002)

Co-expression of Nc^C318S.GMR suppresses the grim^GMR.PH small eye phenotype.

(Hawkins et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

grim^GMR.PH is rescued by Scer\GAL4^GMR.PF/grim^RNAi.UAS.cLa

(Lee et al., 2013)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

grim^GMR.PH

Name Synonyms

glass multimer reporter construct of Hawkins

(Hawkins et al., 2000)

Secondary FlyBase IDs

References (12)

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