FlyBase Allele Report: Dmel\Nct[J2]

General Information

Symbol

Dmel\Nct^J2

Species

D. melanogaster

Name

FlyBase ID

FBal0129201

Feature type

allele

Associated gene

Dmel\Nct

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Hu et al., 2002)

Mutagen

ethyl methanesulfonate

(Hu et al., 2002)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y445term.

(Hu et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:24,853,222..24,853,222 [+]

Nucleotide change:

T24853222R

Amino acid change:

Y445term | nct-PA; Y445term | nct-PC; Y445term | nct-PD; Y445term | nct-PE

Reported amino acid change:

Y445term

Comment:

T to A or G nucleotide change at the third position of Tyr leads to a nonsense mutation (exact site of mutation unspecified)

(Hu et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Hu et al., 2002)

some die during larval stage | recessive

(Hu et al., 2002)

Phenotype Manifest In

larva

(Hu et al., 2002)

sensory mother cell & dorsal mesothoracic disc

(Hu et al., 2002)

Detailed Description

Statement

Reference

Mutant larvae secrete a pupal case but do not form any adult structures and instead collapse into an oily mass within the pupal case. Clusters of sensillum precursors in the wing disc are expanded.

(Hu et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

nct[+]/Nct^J2 is a suppressor of visible phenotype of Scer\GAL4^GMR.APP, grim^UAS.cYa

(Guo et al., 2003)

NOT Suppressor of

Statement

Reference

nct[+]/Nct^J2 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, grim::rpr^gr.UAS

(Guo et al., 2003)

nct[+]/Nct^J2 is a non-suppressor of visible phenotype of grim^GMR.PH

(Guo et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

nct[+]/Nct^J2 is a suppressor of eye phenotype of Scer\GAL4^GMR.APP, grim^UAS.cYa

(Guo et al., 2003)

NOT Suppressor of

Statement

Reference

nct[+]/Nct^J2 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, grim::rpr^gr.UAS

(Guo et al., 2003)

nct[+]/Nct^J2 is a non-suppressor of eye phenotype of grim^GMR.PH

(Guo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

nct^J2/+ suppresses the small eye phenotype caused by expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP}, but does not suppress the small eye phenotype caused by expression of grim^GMR.PH or by expression of grim::rpr^gr.Scer\UAS under the control of Scer\GAL4^GMR.PF.

(Guo et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nct^J2

Nic^J2

(Hu et al., 2002)

nct^J2

(Restrepo et al., 2022, Guo et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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