FlyBase Allele Report: Dmel\grim[UAS.cYa]

General Information

Symbol

Dmel\grim^UAS.cYa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Yoo

FlyBase ID

FBal0150472

Feature type

allele

Associated gene

Dmel\grim

Associated Insertion(s)

Carried in Construct

P{UAS-grim.Y}

Also Known As

uas-grim

Key Links

Transgenic product class

wild_type

(Yoo et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yoo et al., 2002)

Mutagen

in vitro construct

(Yoo et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-grim.Y}

Cytology

Description

UAS regulatory sequences drive expression of grim.

(Yoo et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

grim

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease 1

CEC

(Vorobyeva et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage, with Scer\GAL4^GMR.APP

(Nagel et al., 2021)

increased cell death, with Scer\GAL4^GMR.APP

(Gross et al., 2008)

lethal, with Scer\GAL4^GMR.PF

(Guo et al., 2003)

visible, with Scer\GAL4^GMR.APP

(Herranz et al., 2006, Guo et al., 2003)

visible | adult stage, with Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.APP

(Nagel et al., 2021, Gross et al., 2008, Herranz et al., 2006, Guo et al., 2003)

Detailed Description

Statement

Reference

The expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP induces a small, rough eye phenotype.

(Nagel et al., 2021)

Expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP} induces apoptosis and generates a small, rough eye phenotype.

(Gross et al., 2008)

Flies expressing grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP} have a reduced eye.

(Herranz et al., 2006)

Expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP} results in a small eye phenotype.

(Guo et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible | adult stage phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has decreased size | adult stage phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, enhanceable by crb^M11.M2

(Herranz et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible | adult stage phenotype, suppressible by Mnr^GD9327, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has decreased size | adult stage phenotype, suppressible by Mnr^GD9327, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has increased cell death phenotype, suppressible by X11L^GMR.cGa

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has increased cell death phenotype, suppressible by Hsap\APBA2^GMR.cGa

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has increased cell death phenotype, suppressible by Hsap\APP^GMR.Tag:MYC

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Diap1^GMR.PH

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Psn^C1/Psn[+]

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Psn^D278A.GMR

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by nct[+]/Nct^J2

(Guo et al., 2003)

FBal0366230:, Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Nct^{RNAi.291-696.GMR}/Nct^{RNAi.291-696.GMR}

(Guo et al., 2003)

FBal0366231:, Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by aph-1^{RNAi.29-174.GMR}/aph-1^{RNAi.29-174.GMR}

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Df(2L)3548/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Df(2L)1581/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Df(2L)90/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Df(2L)3910/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by Df(2L)1567/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by +/Df(2R)1547

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, suppressible by BacA\p35^GMR.PH

(Guo et al., 2003)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, grim^UAS.cYa has increased cell death phenotype, non-suppressible by X11L^GMR.cGa/Scer\GAL4^GMR.PF

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has increased cell death phenotype, non-suppressible by X11L^UAS.cGa/Scer\GAL4^GMR.PF

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, non-suppressible by Df(2L)97/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, non-suppressible by Df(2L)4954/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has visible phenotype, non-suppressible by Df(2L)6875/+

(Guo et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, enhanceable by Mnr^EP555, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, enhanceable by crb^M11.M2

(Herranz et al., 2006)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Mnr^GD9327, Scer\GAL4^GMR.APP

(Nagel et al., 2021)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by X11L^GMR.cGa

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Hsap\APBA2^GMR.cGa

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Hsap\APP^GMR.Tag:MYC

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Diap1^GMR.PH

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Psn^C1/Psn[+]

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Psn^D278A.GMR

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by nct[+]/Nct^J2

(Guo et al., 2003)

FBal0366230:, Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Nct^{RNAi.291-696.GMR}/Nct^{RNAi.291-696.GMR}

(Guo et al., 2003)

FBal0366231:, Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by aph-1^{RNAi.29-174.GMR}/aph-1^{RNAi.29-174.GMR}

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Df(2L)3548/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Df(2L)1581/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Df(2L)90/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Df(2L)3910/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by Df(2L)1567/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by +/Df(2R)1547

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, suppressible by BacA\p35^GMR.PH

(Guo et al., 2003)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, grim^UAS.cYa has eye phenotype, non-suppressible by X11L^GMR.cGa/Scer\GAL4^GMR.PF

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, non-suppressible by X11L^UAS.cGa/Scer\GAL4^GMR.PF

(Gross et al., 2008)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, non-suppressible by Df(2L)97/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, non-suppressible by Df(2L)4954/+

(Guo et al., 2003)

Scer\GAL4^GMR.APP, grim^UAS.cYa has eye phenotype, non-suppressible by Df(2L)6875/+

(Guo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of X11L^GMR.cGa strongly suppresses the small, rough eye phenotype found upon expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP}.

Overexpression of X11L^GMR.cGa has no effect on the rough eye phenotype found upon expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PF.

Overexpression of X11L^Scer\UAS.cGa under the control of Scer\GAL4^GMR.PF fails to suppress the small, rough eye phenotype found upon expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP}.

(Gross et al., 2008)

crb^M11.M2 enhances the reduced eye phenotype of animals expressing grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP}.

(Herranz et al., 2006)

The small eye phenotype caused by expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP is completely suppressed by co-expression of Diap1^GMR.PH.

Psn^C1/+ and Nct^J2/+ each suppress the small eye phenotype caused by expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP.

Psn^D278A.GMR suppresses the small eye phenotype caused by expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP.

Expression of Nct^{dsRNA.291-696.GMR} suppresses the small eye phenotype caused by expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP.

Expression of aph-1^{dsRNA.29-174.GMR} suppresses the small eye phenotype caused by expression of grim^UAS.cYa under the control of Scer\GAL4^GMR.APP.

(Guo et al., 2003)

Xenogenetic Interactions

Statement

Reference

The presence of Hsap\APBA2^GMR.cGa strongly suppresses the small, rough eye phenotype found upon expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP}.

(Gross et al., 2008)

The small eye phenotype caused by expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP} is completely suppressed by co-expression of BacA\p35^GMR.PH.

(Guo et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

52016

P{GMR-APP-GAL4}2, P{UAS-grim.Y}2/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

grim^Scer\UAS.cYa

grim^UAS.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yoo

(Yoo et al., 2002)

Secondary FlyBase IDs

References (6)

Report Sections

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