FlyBase Allele Report: Scer\GAL4[pros-V1]

General Information

Symbol

Scer\GAL4^pros-V1

Species

S. cerevisiae

Name

FlyBase ID

FBal0090640

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}pros^V1

Carried in Construct

Also Known As

pros-Gal4, prosV1-Gal4, voila-Gal4, pros^V1-Gal4, prospero-Gal4, pros^voila-Gal4

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Balakireva et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{GawB}pros^V1

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:11,372,578..11,372,578 [+]

(Gao et al., 2024, Guo et al., 2024, Moriya et al., 2024, Katheder et al., 2023, Nagai et al., 2023, Shianiou et al., 2023, Shi et al., 2023, Socha et al., 2023, Ariyapala et al., 2022, Guo et al., 2022, Kubrak et al., 2022, Liu et al., 2022, Malita et al., 2022, Erez et al., 2021, Tang et al., 2021, Tauc et al., 2021, Hadjieconomou et al., 2020, Jin et al., 2020, Flint Brodsly et al., 2019, Gervais et al., 2019, Guo et al., 2019, Hudry et al., 2019, Lakatos et al., 2019, Scopelliti et al., 2019, Zhang et al., 2019, Andriatsilavo et al., 2018, Takeda et al., 2018, Kurz et al., 2017, Liu and Jin, 2017, Nagy et al., 2017, Sallé et al., 2017, Halachmi et al., 2016, Hudry et al., 2016, Khericha et al., 2016, Li et al., 2016, Scopelliti et al., 2014, Zielke et al., 2014, Guenin et al., 2010, Belgacem and Martin, 2002, Balakireva et al., 2000, Gatti et al., 2000, Meunier et al., 2000, Balakireva et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

germ band

(Balakireva et al., 2000)

procephalic neurogenic region

(Balakireva et al., 2000)

embryonic stage 11

neuroblast | segmentally repeated

(Balakireva et al., 2000)

embryonic stage 13 -- 16

embryonic/larval central nervous system

(Balakireva et al., 2000)

antenno-maxillary complex | precursor

(Balakireva et al., 2000)

organism | segmentally repeated | striped

(Balakireva et al., 2000)

second instar larval stage

chordotonal organ | subset

(Balakireva et al., 2000)

second instar larval stage -- third instar larval stage

antenno-maxillary complex

(Balakireva et al., 2000)

pharyngeal sense organ

(Balakireva et al., 2000)

terminal organ

(Balakireva et al., 2000)

third instar larval stage

embryonic/larval mushroom body

(Balakireva et al., 2000)

larval gnathal ganglion

(Balakireva et al., 2000)

larval ventral nerve cord | restricted

(Balakireva et al., 2000)

prepupal stage P1 -- P3

neuron of metathoracic leg disc

Comment: 0-4 hr APF

(Balakireva et al., 2000)

prepupal stage P4

anterior wing margin

Comment: 8 hr APF

(Balakireva et al., 2000)

pupal stage P5 -- P6

chemosensory neuron of dorsal triple row bristle

Comment: 16-24 hr APF

(Balakireva et al., 2000)

chemosensory neuron of ventral triple row bristle

Comment: 16-24 hr APF

(Balakireva et al., 2000)

pupal stage P6

prothoracic leg taste bristle chemosensory neuron

Comment: 24 hr APF

(Balakireva et al., 2000)

mesothoracic leg taste bristle chemosensory neuron

Comment: 24 hr APF

(Balakireva et al., 2000)

metathoracic leg taste bristle chemosensory neuron

Comment: 24 hr APF

(Balakireva et al., 2000)

chemosensory neuron of labellar taste bristle

Comment: 24 hr APF

(Balakireva et al., 2000)

second segment of antenna

Comment: 24 hr APF

(Balakireva et al., 2000)

third segment of antenna

Comment: 24 hr APF

(Balakireva et al., 2000)

adult stage

trichoid sensillum of antennal segment 3

(Balakireva et al., 1998)

adult mushroom body

(Balakireva et al., 1998)

gustatory sensory organ

(Balakireva et al., 1998)

eo neuron

(Balakireva et al., 1998)

taste bristle of wing

(Balakireva et al., 1998)

gnathal ganglion

(Balakireva et al., 1998)

head sensillum | subset

(Balakireva et al., 1998)

brain | restricted

(Balakireva et al., 1998)

taste bristle of leg

(Balakireva et al., 1998)

ventral cibarial sense organ

(Balakireva et al., 1998)

labellar taste bristle

(Balakireva et al., 1998)

interneuron | subset

(Balakireva et al., 1998)

basiconic sensillum of antennal segment 3

(Balakireva et al., 1998)

Kenyon cell

(Balakireva et al., 1998)

adult labral sense organ

(Balakireva et al., 1998)

adult antennal lobe

(Balakireva et al., 1998)

enteroendocrine cell of posterior adult midgut epithelium

(Hudry et al., 2016)

enteroendocrine cell

(Scopelliti et al., 2014)

Additional Information

Statement

Reference

Drives expression in enteroendocrine cells in the midgut, in gustatory receptor neurons, and in the mushroom body.

(FlyBase Curators, 2017)

In adult, specifically expressed in the nervous system. In the CNS, it is expressed mainly in the mushroom bodies and, to a lesser extent, in the antennal lobes. In the PNS, expression is almost entirely restricted to the gustatory sensilla, predominantly in the eo neurons.

(Balakireva et al., 1998)

Marker for

enteroendocrine cell of posterior adult midgut epithelium

(Hudry et al., 2016)

Reflects expression of

pros

(Balakireva et al., 2000)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | male, with tra^UAS.cFa

(Balakireva et al., 1998)

abnormal feeding behavior, with AstC^KK112307

(Kubrak et al., 2022)

abnormal feeding behavior, with AstC^UAS.KO.pCFD6, Spyo\Cas9^UAS.P2

(Kubrak et al., 2022)

abnormal immune response | adult stage, with CG11307^GD15082

(Shianiou et al., 2023)

abnormal immune response | adult stage, with CG11307^KK104223

(Shianiou et al., 2023)

abnormal immune response | adult stage, with jhamt^GD8794

(Shianiou et al., 2023)

abnormal immune response | adult stage, with jhamt^KK103237

(Shianiou et al., 2023)

abnormal immune response | adult stage, with Ms^KK110955

(Shianiou et al., 2023)

abnormal locomotor behavior | male, with tra^UAS.cFa

(Belgacem and Martin, 2002)

abnormal size | larval stage, with Sec20^HMS01172

(Lakatos et al., 2019)

abnormal size | larval stage, with Sec20^KK107334

(Lakatos et al., 2019)

abnormal size | larval stage, with Sec20^NIG.2023R

(Lakatos et al., 2019)

abnormal size | larval stage, with Syx18^JF02263

(Lakatos et al., 2019)

abnormal starvation stress response | adult stage | female, with AstC^KK112307

(Kubrak et al., 2022)

abnormal starvation stress response | adult stage | female, with AstC^UAS.KO.pCFD6, Spyo\Cas9^UAS.P2

(Kubrak et al., 2022)

decreased cell number | adult stage, with Burs^UAS.cDa

(Scopelliti et al., 2014)

decreased fecundity, with CG11307^GD15082

(Shianiou et al., 2023)

decreased fecundity, with CG11307^KK104223

(Shianiou et al., 2023)

decreased fecundity, with jhamt^GD8794

(Shianiou et al., 2023)

decreased fecundity, with jhamt^KK103237

(Shianiou et al., 2023)

decreased fecundity, with Ms^KK110955

(Shianiou et al., 2023)

decreased occurrence of cell division | adult stage, with Burs^UAS.cDa

(Scopelliti et al., 2014)

decreased rate of feeding behavior | female, with AstC^KK112307

(Kubrak et al., 2022)

increased cell number | adult stage, with Atg16^HMS01347

(Nagy et al., 2017)

increased cell number | adult stage, with Burs^KK111063

(Scopelliti et al., 2014)

increased cell number | adult stage, with sli^JF01229

(Nagy et al., 2017)

increased cell size | larval stage, with Sec20^HMS01172

(Lakatos et al., 2019)

increased mortality | conditional, with CG11307^GD15082

(Shianiou et al., 2023)

increased mortality | conditional, with CG11307^KK104223

(Shianiou et al., 2023)

increased mortality | conditional, with Ms^KK110955

(Shianiou et al., 2023)

increased occurrence of cell division | adult stage, with Burs^KK111063

(Scopelliti et al., 2014)

increased occurrence of cell division | adult stage, with spen^KK100153

(Andriatsilavo et al., 2018)

increased sleep | adult stage, with AstC^UAS.KO.pCFD6, Spyo\Cas9^UAS.P2

(Kubrak et al., 2022)

Phenotype Manifest In

adult midgut, with Burs^KK111063

(Scopelliti et al., 2014)

adult posterior midgut epithelium, with Atg16^HMS01347

(Nagy et al., 2017)

adult posterior midgut epithelium, with sli^JF01229

(Nagy et al., 2017)

adult posterior midgut epithelium, with spen^KK100153

(Andriatsilavo et al., 2018)

embryonic/larval garland cell | larval stage, with Sec20^HMS01172

(Lakatos et al., 2019)

embryonic/larval garland cell | larval stage, with Sec20^KK107334

(Lakatos et al., 2019)

embryonic/larval garland cell | larval stage, with Sec20^NIG.2023R

(Lakatos et al., 2019)

embryonic/larval garland cell | larval stage, with Syx18^JF02263

(Lakatos et al., 2019)

enteroblast | adult stage, with Atg16^HMS01347

(Nagy et al., 2017)

enteroblast | adult stage, with sli^JF01229

(Nagy et al., 2017)

intestinal stem cell | adult stage, with Burs^KK111063

(Scopelliti et al., 2014)

intestinal stem cell | adult stage, with Burs^UAS.cDa

(Scopelliti et al., 2014)

late endosome | larval stage, with Sec20^HMS01172

(Lakatos et al., 2019)

late endosome | larval stage, with Sec20^KK107334

(Lakatos et al., 2019)

late endosome | larval stage, with Sec20^NIG.2023R

(Lakatos et al., 2019)

late endosome | larval stage, with Syx18^JF02263

(Lakatos et al., 2019)

prothoracic leg taste bristle, with tra^UAS.cFa

(Meunier et al., 2000)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rab19^LL00490, Scer\GAL4^pros-V1 has increased cell number | adult stage phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Atg16^HMS01347, Scer\GAL4^pros-V1 has increased cell number | adult stage phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Suppressor of

Statement

Reference

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of increased cell number | adult stage phenotype of Rab19^LL00490, Scer\GAL4^pros-V1

(Nagy et al., 2017)

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of increased cell number | adult stage phenotype of Atg16^HMS01347, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Atg16^HMS01347, Scer\GAL4^pros-V1 has adult posterior midgut epithelium phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Atg16^HMS01347, Scer\GAL4^pros-V1 has enteroblast | adult stage phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Rab19^LL00490, Scer\GAL4^pros-V1 has adult posterior midgut epithelium phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Rab19^LL00490, Scer\GAL4^pros-V1 has enteroblast | adult stage phenotype, suppressible by sli^EY10695, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Suppressor of

Statement

Reference

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of adult posterior midgut epithelium phenotype of Atg16^HMS01347, Scer\GAL4^pros-V1

(Nagy et al., 2017)

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of enteroblast | adult stage phenotype of Atg16^HMS01347, Scer\GAL4^pros-V1

(Nagy et al., 2017)

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of adult posterior midgut epithelium phenotype of Rab19^LL00490, Scer\GAL4^pros-V1

(Nagy et al., 2017)

sli^EY10695, Scer\GAL4^pros-V1 is a suppressor of enteroblast | adult stage phenotype of Rab19^LL00490, Scer\GAL4^pros-V1

(Nagy et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Burs^UAS.cDa/Scer\GAL4^pros-V1 rescues Burs^KK111063

(Scopelliti et al., 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

84276

w¹¹¹⁸; P{GawB}pros^V1/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GAL4^Voila-1

Scer\GAL4^Voila-1

Scer\GAL4^pros-V1

Name Synonyms

Secondary FlyBase IDs

References (44)

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