FB2024_03 , released June 25, 2024
Allele: Dmel\BursKK111063
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General Information
Symbol
Dmel\BursKK111063
Species
D. melanogaster
Name
FlyBase ID
FBal0237191
Feature type
allele
Associated gene
Dmel\Burs
Associated Insertion(s)
Carried in Construct
P{KK111063}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK111063}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK111063
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of BursKK111063 under the control of Scer\GAL4Burs.PP leads to developmental defects, including defective wing inflation, but does not lead to changes in midgut homeostasis, as compared with controls.

      Expression of BursKK111063 under the control of Scer\GAL4pros-V1 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) in adults does not result in any obvious developmental defect, but in the midgut results in intestinal stem cell hyperproliferation and abnormal epithelial multilayering, as compared with controls.

      (Scopelliti et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      BursKK111063 is rescued by BursUAS.cDa/Scer\GAL4pros-V1

      (Scopelliti et al., 2014)
      Comments

      Co-expression of BursScer\UAS.cDa partially suppresses the intestinal stem cell hyperproliferation phenotype of flies expressing BursKK111063 under the control of Scer\GAL4pros-V1.

      (Scopelliti et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BursKK111063
      bursKK111063
      Name Synonyms
      Secondary FlyBase IDs
        References (3)