FB2024_03 , released June 25, 2024
Allele: Dmel\Syx18JF02263
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General Information
Symbol
Dmel\Syx18JF02263
Species
D. melanogaster
Name
FlyBase ID
FBal0220653
Feature type
allele
Associated gene
Dmel\Syx18
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02263}
Also Known As
JF02263
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.3.31)
Mutagen
in vitro construct
(Perkins et al., 2009.3.31)
Progenitor genotype
Carried in construct
P{TRiP.JF02263}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02263
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Syx18JF02263 under the control of Scer\GAL4pros-V1 results in larger late endosomes in larval garland cells (Rab7-positive puncta in fluorescence microscopy).

      Clonal expression of Syx18JF02263 under the control of Scer\GAL4Act5C.PP (in combination with Dicer-2, for a more efficient RNAi) affects the distribution of autophagic vesicles in the larval fat body (Atg8-positive puncta in fluorescence microscopy).

      Expressing Syx18JF02263 under the combined control of Scer\GAL4fkh.PH abolishes glue granules in the larval salivary glands; in agreement, all of the (pre)pupae fell down from the wall of the culture vials.

      (Lakatos et al., 2019)

      The expression of Syx18JF02263 under the control of Scer\GAL4SPARC-MI00329-GAL4 (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

      (Ke et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Syx18JF02263
      Name Synonyms
      Secondary FlyBase IDs
        References (8)