FB2024_03 , released June 25, 2024
Allele: Dmel\sqhE21.Tag:FLAG
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General Information
Symbol
Dmel\sqhE21.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0083732
Feature type
allele
Associated gene
Dmel\sqh
Associated Insertion(s)
Carried in Construct
P{sqh-E21}
Key Links
Transgenic product class
missense_variant
(Jordan and Karess, 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Jordan and Karess, 1997)
Mutagen
in vitro construct
(Jordan and Karess, 1997)
Progenitor genotype
Carried in construct
P{sqh-E21}
Cytology
Description

Contains sqh, expressed under its own promoter and containing the amino acid replacement S21E, tagged with Tag:FLAG.

(Jordan and Karess, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
sqh
Encoded product / tool
sqh
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most flw1/Y; sqhE21.T:Zzzz\FLAG/+ flies are viable, but have a crumpled wing phenotype, resembling that of stronger flw alleles.

      (Vereshchagina et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sqhE21.Tag:FLAG is an enhancer of lethal | male phenotype of flwG0172

      (Vereshchagina et al., 2004)
      Suppressor of
      Statement
      Reference

      sqhE21.Tag:FLAG is a suppressor of visible | recessive phenotype of dsh1

      (Winter et al., 2001)

      sqhE21.Tag:FLAG is a suppressor of lethal | recessive | larval stage phenotype of Rok2

      (Winter et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      sqhE21.Tag:FLAG is a non-suppressor of abnormal cell polarity phenotype of Sgt1s2383

      (Andersen et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      sqhE21.Tag:FLAG is a suppressor of myoblast phenotype of Rho172O, Rok2

      (Kim et al., 2015)

      sqhE21.Tag:FLAG is a suppressor | partially of myoblast phenotype of Rho172O, kirrerP298-G4

      (Kim et al., 2015)

      sqhE21.Tag:FLAG is a suppressor of wing hair | increased number phenotype of dsh1

      (Winter et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      sqhE21.Tag:FLAG is a non-suppressor of neuroblast phenotype of Sgt1s2383

      (Andersen et al., 2012)
      Other
      Statement
      Reference

      flw1, sqhE21.Tag:FLAG has wing phenotype

      (Vereshchagina et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of sqhE21.T:Zzzz\FLAG suppresses the myoblast fusion defect seen in Rho172O Rok2 double mutant embryos.

      Expression of sqhE21.T:Zzzz\FLAG partially suppresses the myoblast fusion defects seen in kirrerP298 Rho172O mutant embryos, returning fusion to the level of kirrerP298 mutants alone.

      (Kim et al., 2015)

      The presence of sqhE21.T:Zzzz\FLAG fails to suppress the Sgt1s2383 neuroblast cortical polarity phenotype.

      (Andersen et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      sqhE21.Tag:FLAG partially rescues sqhAX3

      (Jordan and Karess, 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      sqhE21.T:FLAG
      sqhE21.T:Zzzz\FLAG
      sqhE21.Tag:FLAG
      sqhE21
      (Andersen et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)