FlyBase Allele Report: Dmel\Cam[4c1]

General Information

Symbol

Dmel\Cam^4c1

Species

D. melanogaster

Name

FlyBase ID

FBal0083599

Feature type

allele

Associated gene

Dmel\Cam

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Harrisingh et al., 2007)

Mutagen

ethyl methanesulfonate

(Nelson et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: D24N.

(Nelson et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,264,812..12,264,812 [+]

Nucleotide change:

G12264812A

Amino acid change:

Reported amino acid change:

D24N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Nelson et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Nelson et al., 1997)

lethal | recessive

(Nelson et al., 1997)

Phenotype Manifest In

mesothoracic tergum

(Nelson et al., 1997)

wing vein | ectopic

(Nelson et al., 1997)

Detailed Description

Statement

Reference

Cam^4c1 heterozygotes exhibit little effect on the average period of free-running.

(Harrisingh et al., 2007)

Hemizygotes are essentially wild type with respect to bang sensitivity but show marked abnormality in the climb test. Mutation has a detectable maternal effect on egg hatch rate. Transheterozygous combinations with other Cam mutations produces an incompletely penetrant ectopic wing vein phenotype and either lateral or bilateral cuticular 'scabs' on the notum.

(Nelson et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Cam[+]/Cam^4c1 is an enhancer of abnormal circadian rhythm phenotype of Mmmm\PV^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Harrisingh et al., 2007)

Other

Statement

Reference

Cam^4c1, l(2)C43^C43 has partially lethal phenotype

(Nelson et al., 1997)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In combination with l(2)C43^C43 mutants exhibit markedly reduced viability.

(Nelson et al., 1997)

Xenogenetic Interactions

Statement

Reference

A heterozygous Cam^4c1 background in flies expressing Mmmm\PV^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^P2.4.Pdf can result in lengthening of the free-running period, compared to controls, after 3-4 weeks in constant darkness.

(Harrisingh et al., 2007)

Complementation and Rescue Data

Partially complements

Camⁿ³³⁹

(Nelson et al., 1997)

Cam^3c1

(Nelson et al., 1997)

Cam⁵

(Nelson et al., 1997)

Cam^6c4

(Nelson et al., 1997)

Cam⁷