FlyBase Allele Report: Dmel\βTub60D::βTub85D[star]

2.3kb βTub85D genomic fragment (5' untranslated sequences up to codon 19) ligated to a genomic fragment of βTub60D (codon 20 to 3' untranslated sequences). Protein product is identical to the wild type βTub60D protein except for two conservative amino acid replacements: L3I and A18G.

(Hoyle and Raff, 1990)

Allele components

Component

Use(s)

Regulatory region(s)

βTub85D

Encoded product / tool

βTub60D::βTub85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile

(Fackenthal et al., 1995)

Phenotype Manifest In

axoneme

(Fackenthal et al., 1995)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

βTub60D::βTub85D^star has male sterile phenotype, suppressible by βTub85D⁸

(Fackenthal et al., 1995)

βTub60D::βTub85D^star has male sterile phenotype, suppressible by βTub85D³

(Fackenthal et al., 1995)

βTub60D::βTub85D^star has male sterile phenotype, suppressible by βTub85D⁷

(Fackenthal et al., 1995)

βTub60D::βTub85D^star has male sterile phenotype, suppressible by βTub85D^Drv1

(Fackenthal et al., 1995)

NOT suppressed by

Statement

Reference

βTub60D::βTub85D^star has male sterile phenotype, non-suppressible by βTub85D⁶

(Fackenthal et al., 1995)

βTub60D::βTub85D^star has male sterile phenotype, non-suppressible by βTub85Dⁿ

(Fackenthal et al., 1995)

Other

Statement

Reference

βTub60D::βTub85D^star, βTub85D⁶ has male sterile phenotype

(Fackenthal et al., 1995)

βTub60D::βTub85D^star, βTub85D⁸ has male fertile phenotype

(Fackenthal et al., 1995)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

A large mass of motile sperm, equivalent to that in wild type males, is present in the seminal vesicles of βTub60D::βTub85D^star βTub85D⁸ males. βTub60D::βTub85D^star and βTub85D⁶ isoforms disrupt a common aspect of axoneme assembly.

(Fackenthal et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

βTub60D::βTub85D^star

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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