FB2024_03 , released June 25, 2024
Allele: Dmel\βTub85DDrv1
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General Information
Symbol
Dmel\βTub85DDrv1
Species
D. melanogaster
Name
FlyBase ID
FBal0000034
Feature type
allele
Associated gene
Dmel\βTub85D
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
βTub85DD
(Fackenthal et al., 1995)
Cytology
Description

Mutation that destabilises the βTub85DD protein.

(Fackenthal et al., 1995)

Nucleotide substitution: T?A.

(Fackenthal et al., 1995)

Amino acid replacement: L263Q.

(Fackenthal et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,409,206..9,409,206 [-]
Nucleotide change:

T9409206A

Reported nucleotide change:

T?A

Amino acid change:

L263Q | betaTub85D-PA

Reported amino acid change:

L263Q

(Fackenthal et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The testes of homozygous males are characterised by complete lack of microtubule-dependent function in the postmitotic germ cells; no evidence of meiotic spindle activity; spermatid nuclei remain 4N and the spermatid head remains unshaped; spermatids fail to elongate.

      (Fackenthal et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      βTub85DDrv1 is a suppressor of male sterile phenotype of βTub60D::βTub85Dstar

      (Fackenthal et al., 1995)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      βTub85DDrv1 heterozygotes partially rescue the male sterile phenotype of βTub60D::βTub85Dstar; only a few motile sperm are present in the seminal vesicles.

      (Fackenthal et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Revertant.

      (Fackenthal et al., 1995)
      Comments
      Comments

      Class I allele.

      (Fackenthal et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      B2tD+R1
      (Fackenthal et al., 1995)
      TB2D+R1
      β2tD+R1
      (Fuller, 1986)
      βTub85DDrv1
      (Anderson et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)