FB2024_03 , released June 25, 2024
Allele: Dmel\Hsp83+t7.5
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General Information
Symbol
Dmel\Hsp83+t7.5
Species
D. melanogaster
Name
FlyBase ID
FBal0042628
Feature type
allele
Associated gene
Dmel\Hsp83
Associated Insertion(s)
Carried in Construct
P{W82}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Wohlwill and Bonner, 1991)
wild_type
(Wohlwill and Bonner, 1991)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wohlwill and Bonner, 1991)
wild_type
(Wohlwill and Bonner, 1991)
Mutagen
in vitro construct
(van der Straten et al., 1997, Wohlwill and Bonner, 1991, Wohlwill, 1990)
Progenitor genotype
Carried in construct
P{W82}
Cytology
Description

7.5kb genomic BamHI-BglII fragment that encompasses the Hsp83 gene, including 900bp of 5' and 2.5kb of 3' flanking sequences.

(Wohlwill and Bonner, 1991)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp83
Encoded product / tool
Hsp83
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:3,192,339..3,199,897 [+]
Linked to:
BamHI-BglII restriction fragment
(Wohlwill and Bonner, 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      phl::tor12D.hs.sev mutants exhibit a rough eye phenotype due to the recruitment of multiple R7 photoreceptor cells. Removal of one copy of Hsp83 prevents the recruitment of additional R7 cells reverting the phenotype to almost wild type and introduction of Hsp83+t7.5 results in the reappearance of additional R7 cells.

      (van der Straten et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Hsp83+t7.5 is a non-suppressor of lethal phenotype of Cdc37unspecified

      (Kimura et al., 1997)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Lethality of Cdc37 mutants cannot be rescued by up to four copies of Hsp83+t7.5.

      (Kimura et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Hsp83+t7.5 rescues Hsp836-55

      (Bandura et al., 2013)

      Hsp83+t7.5 rescues Hsp8313F3

      (van der Straten et al., 1997)

      Hsp83+t7.5 rescues Hsp839J1

      (van der Straten et al., 1997)

      Hsp83+t7.5 rescues Hsp83P582

      (van der Straten et al., 1997)

      Hsp83+t7.5 rescues Hsp83e3A

      (Cutforth and Rubin, 1994)
      Comments

      Expression of Hsp83+t7.5 rescues the lethality and cell cycle exit defects seen in Hsp836-55 mutants.

      (Bandura et al., 2013)

      Rescues the lethality of the "E(sev)3A" alleles of Hsp83.

      (Cutforth and Rubin, 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Fails to rescue: l(3)63Bbunspecified. Fails to rescue: l(3)63Bdunspecified. Fails to rescue: M(3)63Bunspecified. Fails to rescue: l(3)63Bhunspecified.

      (Wohlwill and Bonner, 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsp83+t7.5
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0033760
      • FBal0038881
      References (7)