FlyBase Allele Report: Dmel\ash1[28]

General Information

Symbol

Dmel\ash1²⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0039148

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(LaJeunesse and Shearn, 1995)

Mutagen

gamma ray

(LaJeunesse and Shearn, 1995, Tripoulas et al., 1994)

Progenitor genotype

Cytology

Description

Southern blot analysis detects no polymorphism in the ash1 gene region.

(LaJeunesse and Shearn, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tripoulas et al., 1994)

Phenotype Manifest In

ovary | heat sensitive (with ash1¹⁴)

(Tripoulas et al., 1994)

Detailed Description

Statement

Reference

Phenotypically like ash1²⁹.

(LaJeunesse and Shearn, 1996)

ash1¹⁴/ash1²⁸ females show a reversible block in oogenesis at 27^oC: an increasing number of stage 14 egg chambers is evident per ovary with increasing temperature.

(Tripoulas et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ash1²⁸/ash1[+], brm² has visible | homeotic phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has visible | homeotic phenotype

(Tripoulas et al., 1994)

Phenotype Manifest In

Enhancer of

Statement

Reference

ash1²⁸ is an enhancer of phenotype of Ubx^abx-1

(LaJeunesse and Shearn, 1995)

ash1²⁸ is an enhancer of phenotype of Ubx^bx-34e

(LaJeunesse and Shearn, 1995)

ash1²⁸ is an enhancer of phenotype of Ubx^abx-2

(LaJeunesse and Shearn, 1995)

ash1²⁸ is an enhancer of phenotype of Ubx^abx-CAC4

(LaJeunesse and Shearn, 1995)

ash1²⁸ is an enhancer of phenotype of Ubx^bx-3

(LaJeunesse and Shearn, 1995)

ash1²⁸ is an enhancer of phenotype of Ubx^bx-34eprv

(LaJeunesse and Shearn, 1995)

Other

Statement

Reference

E(z)¹, ash1²⁸ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)¹, ash1²⁸ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Df(3L)lxd6, ash1²⁸ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Df(3L)lxd6, ash1²⁸ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)⁵, ash1²⁸ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)⁵, ash1²⁸ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

ash1²⁸/ash1[+], brm² has scutellum phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm² has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm² has haltere phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm² has prothoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has haltere phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has prothoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸, brm[+]/brm² has prothoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸, brm[+]/brm² has scutellum phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has scutellum phenotype

(Tripoulas et al., 1994)

ash1²⁸, brm[+]/brm² has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸, brm[+]/brm² has haltere phenotype

(Tripoulas et al., 1994)

ash1²⁸, brm⁵/brm[+] has metathoracic leg phenotype

(Tripoulas et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygotes of E(z)⁵, E(z)¹ or Df(3L)lxd6 with ash1²⁸ result in transformations of the third leg to the second leg and first leg to second leg. This phenotype is that expected from partial loss of function of Scr and Ubx.

(LaJeunesse and Shearn, 1996)

Heterozygotes of ash1¹, ash1⁶, and ash1²⁸ with brm² have homeotic transformations of the third to the second leg. The expressivity of the transformed leg is variable, some have only a second leg apical bristle while others have a second leg preapical bristle as well. There is a lower penetrance of third leg transformations among flies heterozygous for ash1¹, ash1⁶, and ash1²⁸ with brm⁵. Degree of penetrance corresponds to the severity of the ash1 allele (ash1¹ < ash1⁶ < ash1²⁸). There is a lower penetrance of partial homeotic transformation of the haltere to the wing, or dorsal metathoracic cuticle to mesothoracic cuticle, and an even lower penetrance of first leg to second leg transformations.

(Tripoulas et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

(Tripoulas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ash1²⁸

γ3.3

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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