FlyBase Allele Report: Dmel\Ubx[abx-1]

General Information

Symbol

Dmel\Ubx^abx-1

Species

D. melanogaster

Name

FlyBase ID

FBal0017513

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

abx¹, abx, bx⁷

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Peifer and Bender, 1986, Bender et al., 1983, Lewis, 1980)

Progenitor genotype

Caused by aberration

Tp(3;3)Ubx^abx-1

Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)

Description

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

Mutation in downstream control region.

(Irvine et al., 1993)

Deletion internal to Ubx at +47kb with respect to transcription start site (in the major intron).

(Muller and Bienz, 1991)

Deletion of DNA within the abx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Deletion within an intron of the Ubx transcription unit.

(Little et al., 1990)

Deletion in the Ubx coding region.

(Mathog, 1990)

Deletion of DNA.

(Micol et al., 1990)

Deletion in the abx regulatory region of Ubx.

(Simon et al., 1990)

Deletion from position -79 to -73kb of the Ubx locus.

(Peifer and Bender, 1986)

Ubx^abx-1 is associated with a 6kb deletion.

(Casanova et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Schneiderman et al., 1993)

visible | homeotic

(Bender et al., 1983)

visible | homeotic (with Df(3R)P2)

(Rivlin et al., 2001)

visible | recessive

(Simon et al., 1990, Casanova et al., 1985)

Phenotype Manifest In

adult mesothoracic segment

(Casanova et al., 1985)

adult mesothoracic segment anterior compartment | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

adult mesothoracic segment posterior compartment (with Df(3R)P2)

(Rivlin et al., 2001)

adult metathoracic segment

(Schneiderman et al., 1993, Casanova et al., 1985, Bender et al., 1983)

adult metathoracic segment anterior compartment

(Castelli-Gair and Garcia-Bellido, 1990)

adult metathoracic segment anterior compartment (with Df(3R)P2)

(Rivlin et al., 2001)

adult muscle system & abdominal segment 1

(Roy and VijayRaghavan, 1997)

adult prothoracic segment posterior compartment | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

coxal tergal remotor muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

direct flight muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

ectoderm & metathoracic segment

(Fernandes et al., 1994)

giant fiber neuron

(Schneiderman et al., 1993)

haltere

(LaJeunesse and Shearn, 1995, Simon et al., 1990, Peifer and Bender, 1986, Cole and Palka, 1982, Lewis, 1980)

haltere (with Df(3R)P2)

(Rivlin et al., 2001)

haltere | anterior

(Bender et al., 1983)

katepimeron

(Peifer and Bender, 1986)

larval mesothoracic segmental nerve | adult stage

(Teugels and Ghysen, 1985)

larval metathoracic intersegmental nerve | adult stage | dorsal

(Teugels and Ghysen, 1985)

larval metathoracic intersegmental nerve | adult stage | ventral

(Teugels and Ghysen, 1985)

larval metathoracic segmental nerve | adult stage | dorsal

(Teugels and Ghysen, 1985)

lateral oblique dorsal muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

metathoracic laterotergite

(Lewis, 1980)

metathoracic leg

(LaJeunesse and Shearn, 1995)

metathoracic leg | anterior

(Peifer and Bender, 1986, Bender et al., 1983)

metathoracic segment

(Castelli-Gair et al., 1992)

metathoracic segment | dorsal

(Peifer and Bender, 1986)

myoblast

(Fernandes et al., 1994)

tergosternal muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

tergotrochanter muscle cell

(Schneiderman et al., 1993)

wing | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

Detailed Description

Statement

Reference

Ubx^LDN/Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1 adults show transformation of the distal part of the haltere (the capitellum) into the wing; the haltere is bigger than normal and has bristles on the margins and veins on the surface.

(de Navas et al., 2011)

The haltere is partially transformed to a wing in Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1/Ubx^LDN flies.

(de Navas et al., 2006)

Ubx^abx-1/Df(3R)P2 flies show transformation of the posterior compartment of T2 (T2p) and the anterior compartment of T3 (T3a) into T1p and T2a. The homeotically transformed T3 segment can contain homeotic DVM-I, DVM-II, DVM-III and DFM muscles. Homeotic DLMs are not seen. The haltere is partially transformed into a small wing. Ubx^abx-1 Ubx^bx-3 Ubx^61d Ubx^pbx-1/Df(3R)P2 mutants show transformation of T3 into T2 resulting in the replacement of halteres with a second set of wings. The homeotically transformed T3 segment resembles T2 in size. The homeotically transformed T3 segment can contain homeotic DVM-I, DVM-II, DVM-III, DLM and DFM muscles. The homeotic DVM-I muscle is composed of one fibre and the diameter of the homeotic DVM-I fibre is less than that seen in T2.

(Rivlin et al., 2001)

Ubx^abx-1, Ubx^bx-3 and Ubx^pbx-1 triple mutants cause muscle patterning defects in A1 of pupae, transforming them towards a T3 thoracic identity.

(Roy and VijayRaghavan, 1997)

Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1 triple mutant adults have four wings.

(Roy et al., 1997)

Double heterozygotes with ash1 mutations exhibit transformation of third leg to second leg identity and haltere to wing transformation.

(Tripoulas et al., 1996)

In Ubx^abx-1 Ubx^pbx-1 Ubx^bx-3 triple mutant flies the T3 ectoderm transforms toward T2 identity. Transformation changes the pattern of myoblasts on the transformed haltere disc and their pattern of migration, but indirect flight muscles do not form as there are no larval templates. The haltere disc is almost completely transformed into a wing disc. Adults have two pairs of wings, but the homeotically transformed T3 has only rudimentary indirect flight muscles.

(Fernandes et al., 1994)

The giant fibre (GF) of Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1/Df(3R)P2 mutants makes a midline tuft and extends a lateral process to T2 and T3 segment. In the presence of ben¹ the GF is capable of extending a process into the T3 segment but no lateral processes from the midline.

(Muralidhar and Thomas, 1993)

Flies triply mutant for Ubx^abx-1, Ubx^bx-3 and Ubx^pbx-1 over Df(3R)P2 have a transformed metathorax including neural elements and jump muscle, that function in the escape-jump response within that segment. Corresponding transformation of the flight muscles is infrequent.

(Schneiderman et al., 1993)

Ubx¹/Ubx^abx-1 transheterozygotes are viable, with the following transformation in the adult: T3a to T2a.

(Castelli-Gair et al., 1992)

Increases the frequency of the trx bithorax-variegated phenotype (partial transformation of T3 to T2, mostly in the anterior compartment) in heterozygous combination with Df(3R)red-P52.

(Castelli-Gair and Garcia-Bellido, 1990)

Transformation of parasegment 5 structures to parasegment 4. Adults display transformation of anterior haltere to anterior wing.

(Simon et al., 1990)

Haltere are transformed to wing and are 15-20% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 8-9 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern. Phenotype can be suppressed by su(Hw) mutations.

(Peifer and Bender, 1986)

Variable, often asymmetrical, transformation of T3a toward T2a, and variable transformation of T2p to T1p. Transformation of T2p to T1p is stronger at 17^oC. Flies frequently show a humerus-like structure in the dorsal region, anterior to (and normally some distance from) the transformed mesothorax.

(Casanova et al., 1985)

Homozygous or hemizygous flies have a number of abnormal transversal fascicles in the CNS; the posterior internal T2, anterior dorsal T3, anterior ventral T3 and posterior dorsal T3 fascicles are affected.

(Teugels and Ghysen, 1985)

Homozygotes show variable transformation of haltere to wing, which may or may not effect the anterior compartment. A pair of metathoracic papillae characteristic of the normal haltere is usually present. The ANWP sensilla are usually absent from the transformed appendage, the tegula sensilla are always present, the proximal, medial and distal radius sensilla show much variability and may be well formed or absent, v.Rad.A usually appears wing-like, v.Rad.B. sensilla are usually absent, and the v.Rad.C sensilla are replaced by a field of haltere sensilla. Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1 flies have a transformation of haltere to wing. The homeotic appendage is somewhat smaller than a normal wing, but usually has the full wild-type complement of wing sensilla, with each type located in the normal position and having normal morphology. The only exception is an occasional decrease in the number of sensilla in fields d.Rad.B and d.Rad.C, and rarely, one or a few extra haltere pedicellar bristles.

(Cole and Palka, 1982)

RK2. Heterozygotes exhibit defects in the halteres, variable transformation of metanotum to mesonotum. Phenotype is not suppressed by su(Hw)². Heterozygotes over Ubx pbx mutations show slight pbx-like effect.

(Lewis, 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^abx-1 has phenotype, enhanceable by ash1²⁸

(LaJeunesse and Shearn, 1995)

Ubx^abx-1 has phenotype, enhanceable by ash2¹⁸

(LaJeunesse and Shearn, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of abd-A^{1dB5.Scer\UAS} results in an almost complete rescue of the transformed haltere phenotype of Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1/Ubx^LDN flies. The P{GawB}Ubx^LDN insertion within the Ubx^LDN flies drives expresssion of abd-A^{1dB5.Scer\UAS}.

(de Navas et al., 2006)

Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1/Ubx^lac1 combination transforms the metathorax into mesothorax (including transformation of halteres into wings). This phenotype can be rescued by Scer\GAL4^Bx-MS1096 induced expression abd-A. Ectopic expression of Abd-B allows partial rescue.

(Casares et al., 1996)

Double heterozygotes with ash1²⁸ exhibit haltere to wing transformation and third to second leg transformation. Double heterozygotes with ash2¹⁸ exhibit haltere to wing transformation.

(LaJeunesse and Shearn, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Ubx^bx-34e

(Lewis, 1980)

Ubx^bx-3

(Lewis, 1980)

Ubx^bx-1

(Lewis, 1980)

Comments

The partial transformation of haltere into wing which is seen in Ubx^LDN/Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1 flies is strongly suppressed by expression of either Ubx^Scer\UAS.cCa or Ubx^{IIa.Scer\UAS.cRa} under the control of Scer\GAL4^Ubx-LDN.

The partial transformation of haltere into wing which is seen in Ubx^LDN/Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1 flies is partially suppressed by expression of one copy of Ubx^{IVa.Scer\UAS.cRa} under the control of Scer\GAL4^Ubx-LDN and is almost completely suppressed by expression of two copies of Ubx^{IVa.Scer\UAS.cRa} under the control of Scer\GAL4^Ubx-LDN.

(de Navas et al., 2011)

(Casares et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (7)

Bloomington

3413

Ubx^abx-1/TM1

1900

Df(3R)red-P52, Ubx^abx-1/TM1

Kyoto

107035

Ubx^abx-1 / TM1

106565

Df(3R)red-P52, Ubx^abx-1/TM1

106812

Ubx^abx-1 Ubx^bx-3 Ubx^pbx-1/Ubx^61d

101567

Ubx^abx-1 Ubx^pbx-1 e¹¹ / TM1, Me¹ kni^ri-1 Sb^sbd-l

101566

Ubx^abx-1 Ubx^bx-3 Ubx^61d Ubx^pbx-1 / TM1, Me¹ kni^ri-1 Sb^sbd-l

Notes on Origin

Discoverer

Lewis, September 1959.

(Lewis, 1980)

Lewis.

(Peifer and Bender, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Ubx^abx-1

abx

(Paul et al., 2021, Bischof et al., 2018, de Navas et al., 2011, Makhijani et al., 2007, de Navas et al., 2006, Bajpai et al., 2004, Crow and Bender, 2004, Rivlin et al., 1997, Roy and VijayRaghavan, 1997, Roy et al., 1997, Casares et al., 1996, Shashidhara et al., 1995, Fernandes et al., 1994, Muralidhar and Thomas, 1993, Schneiderman et al., 1993, Cash et al., 1992, Weinzierl et al., 1987, Cole and Palka, 1982)

abx-1

(O'Keefe et al., 2005)

bx⁷

(Bender et al., 1983, Lewis, 1980)

Name Synonyms

Secondary FlyBase IDs

References (43)

Report Sections

Open Close