FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxbx-1
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General Information
Symbol
Dmel\Ubxbx-1
Species
D. melanogaster
Name
FlyBase ID
FBal0017516
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
412{}Ubxbx-1
Carried in Construct
Also Known As
bx1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Peifer and Bender, 1986, Bender et al., 1983)
Progenitor genotype
Associated Insertion(s)
412{}Ubxbx-1
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)
Description

Insertion of 412 element into the bx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Insertion of a 412 element.

(Micol et al., 1990)

412 insertion at -60kb of the Ubx locus.

(Peifer and Bender, 1986)

Insertion of a 412 element at map position -60kb.

(Bender et al., 1983)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Phenotype shows variable penetrance and expressivity, and erratic specificity.

      (Botas et al., 1988)

      Different genetic combinations of Pc alleles and Ubx alleles suggest that the products of the bx region of Ubx are responsible for the "cbx" phenotype of the Pc mutations and in the absence of Pc the overexpression of bx gene products suppresses the pbx insufficiency phenotype in the posterior segments.

      (Capdevila et al., 1986)

      Halteres are transformed to wings and are 3-15% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 2-3 hypopleural bristles are still present and the anterior third leg displays a weak transformation to anterior second leg, as seen by the bristle pattern.

      (Peifer and Bender, 1986)

      Ubxbx-1 failed to show the "ppx" transformation at 17oC.

      (Casanova et al., 1985)

      Homozygotes have a stronger homeotic transformation phenotype than hemizygous Ubxbx-1/Df(3R)P115 flies. The occurrence of costa (Co) bristles in the proximal haltere (medial structures) and medial triple row (MTR) bristles in the distal haltere (distal structures) increases with temperature in homozygotes but not in hemizygotes. The temperature sensitive period for the increase in MTR and Co bristles is during the third larval stage.

      (Sanchez-Herrero and Morata, 1983)

      The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubxbx-1.

      (Capdevila and Garcia-Bellido, 1981)

      Halteres are enlarged.

      (Duncan and Kaufman, 1975)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      UbxCbx-1/Ubxbx-1, ssa has visible phenotype

      (Kuzin et al., 1997)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ubxbx-1 has phenotype, suppressible by su(Ubxbx-1)1

      (Manoukian et al., 1992)
      NOT suppressed by
      Statement
      Reference

      Ubxbx-1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ssa Ubxbx-1 UbxCbx-1 hemizygotes are characterised by reduction of the posterior part of the wing (UbxCbx-1 phenotype) and by deterioration of tarsus segmentation of the second leg.

      (Kuzin et al., 1997)

      The Ubxbx-1 phenotype is enhanced by su(s) mutations, and suppressed by su(Ubxbx-1)1.

      (Manoukian et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      Ubxabx-1

      (Lewis, 1980)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (17)
      Notes on Origin
      Discoverer

      Bridges.

      (Peifer and Bender, 1986)
      Comments
      Comments

      Two modifiers of Ubxbx-1 penetrance, located on the X and 3rd chromosome, are described.

      (Larsen, 1989)

      The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

      (Castelli-Gair et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (24)