FlyBase Allele Report: Dmel\Ubx[Cbx-1]

General Information

Symbol

Dmel\Ubx^Cbx-1

Species

D. melanogaster

Name

FlyBase ID

FBal0017563

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

?{}Ubx^Cbx-1

Carried in Construct

Also Known As

Cbx¹, Cbx

Key Links

Allele class

neomorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

neomorphic allele - genetic evidence

(Botas et al., 1988)

Mutagen

X ray

(Bender et al., 1983, Lindsley and Grell, 1968)

Progenitor genotype

Associated Insertion(s)

?{}Ubx^Cbx-1

Cytology

Polytene chromosomes normal.

(Lindsley and Grell, 1968)

Description

Insertion of 17kb into the second intron of Ubx, at position 3R:16721339 (release 6 coordinates); the insertion contains sequence from two Ubx upstream regulatory regions, 16kb from the pbx region and 1kb from the bxd region. The insertion is within the transcribed region of asRNA:PS4, approximately 1.1kb downstream of the transcription start sites.

(Hermann et al., 2022)

Duplication of an upstream genomic fragment. The duplicated copy is at an intronic location approximately 13kb downstream of the Ubx transcription start site.

(Castelli-Gair et al., 1992)

Insertion of Ubx DNA (the segment that is deleted in Ubx^pbx-1) in inverted orientation.

(Castelli-Gair et al., 1990)

Transposition of part of the bxd region in inverted orientation into the second intron of the Ubx transcription unit.

(Gonzalez-Gaitan et al., 1990)

Insertion of 17kb Ubx^pbx-1 DNA into Ubx.

(Mathog, 1990)

Insertion of part of the pbx region of the Ubx gene into the second intron of Ubx.

(Botas et al., 1988)

Inverted insertion of a 17kb fragment from map position -3 to +14kb into map position -44kb.

(Bender et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes show transformation of the posterior wing to a hemi-haltere.

(Boube et al., 2014)

heterozygous animals exhibit a transformation of the wing to a haltere phenotype with complete penetrance but a variable expressivity.

(Bejarano and Busturia, 2004)

z^a, Ubx^Cbx-1/+ flies do not differ from Ubx^Cbx-1/+, whereas the wings of z^a, Ubx^1:Cbx-1/+ are considerably less like halteres than those of Ubx^1:Cbx-1/+.

(Goldsborough and Kornberg, 1996)

The mesothorax phenotype is reduced in combination with RpII215^Ubl or RpS17⁴. The dominant wing phenotype is 100% penetrant, occurring in the posterior compartment and variably in the anterior compartment. Ubx^Cbx-1/Ubx¹⁹⁵ transheterozygotes show transformation of T3 towards T2, and sometimes of A1a towards T3a.

(Gonzalez-Gaitan et al., 1990)

Causes dominant partial transformation of wing tissue into haltere in the mesothorax. Shows weak recessive metathoracic and first abdominal transformation phenotypes.

(Micol and Garcia-Bellido, 1988)

Posterior wing is transformed into posterior haltere in heterozygotes, and the posterior notal tissue is reduced.

(Bender et al., 1983)

Heterozygotes show a transformation of posterior wing to haltere.

(Duncan, 1982)

Heterozygotes show a transformation of wing to haltere. Ubx^Cbx-1 completely inhibits the homoeosis normally seen in vg^W flies; there is no wing blade in the capitellum, the haltere forms but is incomplete, the hinge sensillae are present, but the hairy regions in the anterior margin of the scabellum and pedicel are deleted. The normal posterior part of the wing is not seen, but the duplicated posterior wing tissue found in vg^W flies is present in vg^W Ubx^Cbx-1 flies.

(Bownes and Roberts, 1981)

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubx^Cbx-1.

(Capdevila and Garcia-Bellido, 1981)

Wings are transformed to halteres. Ubx¹³⁰/Ubx^Cbx-1 flies show a temperature sensitive phenotype; flies grown at 29^oC have a slight conversion of haltere to wing and strong transformation of wing to haltere, while those grown at 17^oC have a strong haltere to wing transformation and a slight transformation of wing to haltere. The Ubx^Cbx-1 transformation in the wing is generally reduced and the Ubx¹³⁰ transformation in the haltere is generally enhanced in the transheterozygote, compared to heterozygous or homozygous Ubx^Cbx-1 or Ubx¹³⁰ flies respectively.

(Kauffman, 1981)

Ubx^Cbx-1/+ and Ubx^Cbx-1/Ubx^Cbx-1 virtually indistinguishable and have small wings. The posterior portion of the mesothorax transformed into a structure that resembles posterior portion of metathorax. Wings have veins L1, L2, and L3 only. In extreme cases, entire mesothorax resembles metathorax so that wings resemble halteres. Metathorax is wild type. Ubx^Cbx-1 acts as dominant suppressor of homozygous pbx and partial suppressor of bx and bxd. RK2.

(Lindsley and Grell, 1968)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ubx^Cbx-1 has visible | adult stage phenotype, enhanceable by Pc³

(Hermann et al., 2022)

Ubx^Cbx-1 has visible | adult stage phenotype, enhanceable by asRNA:PS4^ΔP

(Hermann et al., 2022)

Ubx^Cbx-1 has visible | dominant phenotype, enhanceable by Pcl¹

(Duncan, 1982)

Suppressed by

Statement

Reference

Ubx^Cbx-1 has visible phenotype, suppressible by MED19²/P{EPgy2}EY16159

(Boube et al., 2014)

Ubx^Cbx-1 has homeotic phenotype, suppressible by MED19²/P{EPgy2}EY16159

(Boube et al., 2014)

Other

Statement

Reference

Ubx^Cbx-1/Ubx^bx-1, ss^a has visible phenotype

(Kuzin et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ubx^Cbx-1 has wing phenotype, enhanceable by Pc³

(Hermann et al., 2022)

Ubx^Cbx-1 has wing phenotype, enhanceable by asRNA:PS4^ΔP

(Hermann et al., 2022)

Ubx^Cbx-1 has haltere | ectopic phenotype, enhanceable by Trl^R85

(Bejarano and Busturia, 2004)

Ubx^Cbx-1 has wing phenotype, enhanceable by Trl^R85

(Bejarano and Busturia, 2004)

Ubx^Cbx-1 has wing phenotype, enhanceable by Pcl¹

(Duncan, 1982)

Suppressed by

Statement

Reference

Ubx^Cbx-1 has haltere | ectopic phenotype, suppressible by MED19²/P{EPgy2}EY16159

(Boube et al., 2014)

NOT suppressed by

Statement

Reference

Ubx^Cbx-1 has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

Ubx^Cbx-1/Ubx^bx-1, ss^a has mesothoracic tarsal segment phenotype

(Kuzin et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The transformation of posterior wing to hemi-haltere seen in Ubx^Cbx-1 homozygotes is no longer seen if the flies are also carrying MED19²/P{EPgy2}EY16159 and the cellular trichomes are reoriented along the long wing axis.

(Boube et al., 2014)

Ubx^Cbx-1/Trl^R85 flies show a 100% penetrance of the wing to haltere transformation seen in Ubx^Cbx-1 mutants, but with much higher expressivity, showing itself in a 40% reduction in wing size on average.

(Bejarano and Busturia, 2004)

ss^a Ubx^bx-1 Ubx^Cbx-1 hemizygotes are characterised by reduction of the posterior part of the wing (Ubx^Cbx-1 phenotype) and by deterioration of tarsus segmentation of the second leg.

(Kuzin et al., 1997)

Pcl¹/+; Ubx^Cbx-1/+ flies show an almost complete wing to haltere transformation.

(Duncan, 1982)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

3433

Ubx^Cbx-1/T(2;3)ap^Xa, ap^Xa

3473

Ubx^9.22 Ubx^Cbx-1 Sb^sbd-1/TM1

3431

Ubx^Cbx-1 Ubx^bxd-1/T(2;3)ap^Xa, ap^Xa

1255

TM6B, Dr^Mio Tb⁺/Ubx^Cbx-1 Ubx¹ gl³

Kyoto

108943

TM6B, Dr^Mio Tb⁺/Ubx^Cbx-1 Ubx¹ gl³

Notes on Origin

Discoverer

Bacon, Aug. 1949.

(Lindsley and Grell, 1968)

Comments

Temperature-shift experiments show that the temperature sensitive period in Ubx¹³⁰/Ubx^Cbx-1 flies extends throughout embryonic and larval life.

(Kauffman, 1981)

The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpII215^Ubl. This reduction of the Cbx phenotype follows the order: Ubx^Cbx-Hm > Ubx^Cbx-2RM = Ubx^Cbx-2 = Ubx^Cbx-M1 > Ubx^Cbx-1RM = Ubx^Cbx-1 = Ubx^Cbx-3 = Ubx^Cbx-Twt. The Cbx mesothorax phenotype is reduced in a number of Cbx mutations in combination with RpS17⁴. This reduction of the Cbx phenotype follows the order: Ubx^Cbx-2RM > Ubx^Cbx-2 = Ubx^Cbx-M1 > Ubx^Cbx-1 = Ubx^Cbx-1RM.

(Gonzalez-Gaitan et al., 1990)

The adult wing phenotypes of flies carrying Ubx^Cbx-1 in cis with Ubx loss of function mutations and in trans with rearrangements in the bithorax complex suggest that Ubx^Cbx-1 induces ectopic expression of a paired normal Ubx gene, and that this expression is enhanced by reducing the levels of the wild-type Pc product.

(Castelli-Gair et al., 1990)

Ubx mutants have been classified into "transvection groups", on the basis of transvection tests with Ubx^bx-34e, Ubx^pbx-2, and Ubx^Cbx-1 Ubx¹ mutants.

(Mathog, 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

References (33)

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