FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxabx-CAC4
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General Information
Symbol
Dmel\Ubxabx-CAC4
Species
D. melanogaster
Name
FlyBase ID
FBal0017515
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
H{}Ubxabx-CAC4
Carried in Construct
Also Known As
abxCAC4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Peifer and Bender, 1986)
Progenitor genotype
Associated Insertion(s)
H{}Ubxabx-CAC4
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)
Description

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

Deletion of Ubx DNA and insertion of hobo in the abx regulatory region.

(Castelli-Gair and Garcia-Bellido, 1990)

Deletion within an intron of the Ubx transcription unit, together with insertion of a hobo at the site of the deletion.

(Little et al., 1990)

Insertion of a hobo and deletion of Ubx sequences.

(Micol et al., 1990)

Deletion in the abx regulatory region of Ubx.

(Simon et al., 1990)

hobo insertion and a deletion from position -80 and -66kb of the Ubx locus.

(Peifer and Bender, 1986)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Increases the frequency of the trx bithorax-variegated phenotype (partial transformation of T3 to T2, mostly in the anterior compartment) in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Transformation of parasegment 5 structures to parasegment 4. Adults display transformation of anterior haltere to anterior wing.

      (Simon et al., 1990)

      Halteres are transformed to wings and are 15-30% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 8-10 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern.

      (Peifer and Bender, 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Ubxabx-CAC4 has phenotype, enhanceable by ash128

      (LaJeunesse and Shearn, 1995)

      Ubxabx-CAC4 has phenotype, enhanceable by ash218

      (LaJeunesse and Shearn, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double heterozygotes with ash128 exhibit haltere to wing transformation and third to second leg transformation. Double heterozygotes with ash218 exhibit haltere to wing transformation.

      (LaJeunesse and Shearn, 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Adler.

      (Peifer and Bender, 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (8)