FlyBase Allele Report: Dmel\stg[AR2]

General Information

Symbol

Dmel\stg^AR2

Species

D. melanogaster

Name

FlyBase ID

FBal0035718

Feature type

allele

Associated gene

Dmel\stg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Duronio and O'Farrell, 1994)

loss of function allele

(Edgar and Datar, 1996)

Mutagen

P-element activity

(Edgar et al., 1994)

Progenitor genotype

stg^AA53

(Edgar et al., 1994)

Caused by aberration

Df(3R)stg^AR2

Cytology

Description

Deletion beginning at site of P element insertion and extending beyond anon-99A.

(Edgar et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | embryonic stage

(Quinn et al., 2004, Lehman et al., 1999)

female sterile

(Edgar and Datar, 1996)

increased cell size | embryonic stage | recessive

(Quinn et al., 2004)

lethal - all die during embryonic stage | recessive

(Quinn et al., 2004)

some die during embryonic stage | recessive

(Quinn et al., 2004)

visible | recessive

(Mozer and Easwarachandran, 1999)

Phenotype Manifest In

eye

(Mozer and Easwarachandran, 1999)

eye photoreceptor cell

(Mozer and Easwarachandran, 1999)

macrochaeta

(Mozer and Easwarachandran, 1999)

ommatidium

(Mozer and Easwarachandran, 1999)

ventral furrow, with Scer\GAL4^{VP16.mat.αTub67C}, stg^UAS.cNa

(Großhans and Wieschaus, 2000)

Detailed Description

Statement

Reference

Cycle 14 stg^AR2/stg^AR2 embryos contain no mitotic cells, and are composed entirely of large G2 cells.

(Quinn et al., 2004)

Postblastoderm cell divisions are completely blocked in stg^AR2 mutants.

(Lehman et al., 1999)

Eye of adults heterozygous with stg^hwy show rough and reduced eyes, missing macrochaetae and ommatidia with one or more extra photoreceptor cells.

(Mozer and Easwarachandran, 1999)

Embryos derived from germ line clones proceed through cycles 1-13 normally.

(Edgar and Datar, 1996)

Transheterozygotes with stg^knot are pharate adult lethal, the few escapers exhibit rough eyes, missing bristles and defective abdominal cuticle, and have low fertility.

(White-Cooper et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

stg^AR2 is an enhancer of visible | recessive phenotype of CycE^JP

(Secombe et al., 1998)

stg^AR2 is an enhancer of decreased occurrence of cell division | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

Suppressor of

Statement

Reference

stg^AR2/stg[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

stg^AR2/stg[+] is a suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

stg^AR2 is a suppressor of visible phenotype of rux³

(Thomas et al., 1994)

NOT Suppressor of

Statement

Reference

stg^AR2/stg[+] is a non-suppressor of male sterile phenotype of rux⁸

(Thomas et al., 1994)

Other

Statement

Reference

hry²⁶, stg^AR2 has partially lethal phenotype

(Bianchi-Frias et al., 2004)

hryⁱ²², stg^AR2 has partially lethal phenotype

(Bianchi-Frias et al., 2004)

hryⁱ²²/h[+], stg^AR2 has partially lethal phenotype

(Bianchi-Frias et al., 2004)

h[+]/hry²⁶, stg^AR2 has partially lethal phenotype

(Bianchi-Frias et al., 2004)

Scer\GAL4^neur-P72, Wee1^UAS.cPa, stg^AR2 has decreased occurrence of cell division phenotype

(Fichelson and Gho, 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

stg^AR2 is an enhancer of wing margin bristle | ectopic phenotype of Scer\GAL4^bbg-C96, arm^UAS.cWa

(Marygold and Vincent, 2003)

stg^AR2 is an enhancer of wing margin bristle | ectopic phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Marygold and Vincent, 2003)

stg^AR2 is an enhancer of eye phenotype of CycE^JP

(Secombe et al., 1998)

stg^AR2 is an enhancer of eye disc posterior to the morphogenetic furrow | larval stage phenotype of CycE^JP

(Secombe et al., 1998)

Suppressor of

Statement

Reference

stg^AR2/stg[+] is a suppressor of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

stg^AR2/stg[+] is a suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

stg^AR2/stg[+] is a suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

stg^AR2 is a suppressor of eye phenotype of rux³

(Thomas et al., 1994)

stg^AR2/stg[+] is a suppressor of eye phenotype of rux⁸

(Thomas et al., 1994)

Other

Statement

Reference

Scer\GAL4^neur-P72, Wee1^UAS.cPa, stg^AR2 has macrochaeta phenotype

(Fichelson and Gho, 2004)

Scer\GAL4^neur-P72, Wee1^UAS.cPa, stg^AR2 has trichogen cell phenotype

(Fichelson and Gho, 2004)

Scer\GAL4^neur-P72, Wee1^UAS.cPa, stg^AR2 has tormogen cell phenotype

(Fichelson and Gho, 2004)

Scer\GAL4^neur-P72, Wee1^UAS.cPa, stg^AR2 has external sensory organ precursor cell I phenotype

(Fichelson and Gho, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced size of the posterior compartment of the wing that is seen in animals expressing crol^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is suppressed if they are also heterozygous for stg^AR2.

(Mitchell et al., 2008)

When wee^Scer\UAS.cPa is driven by Scer\GAL4^neur-P72 in stg^AR2 animals exhibit severe bristle loss.

(Fichelson and Gho, 2004)

The block in cycle 14 mitosis and increased cell-size in cycle 14 embryos seen in stg^AR2/stg^AR2 embryos is suppressed by pUf68^EP3058/pUf68^EP3058. Unlike stg^AR2 homozygotes, stg^AR2; pUf68^EP3058 double homozygotes survive embryogenesis and die between first and second instar.

(Quinn et al., 2004)

Dominantly enhances the rough eye phenotype of CycE^JP homozygotes. One copy of stg^AR2 has no effect on the reduction in the number of cells entering S phase posterior to the morphogenetic furrow seen in CycE^JP homozygotes. One copy of stg^AR2 enhances the reduction in the number of mitotic cells posterior to the morphogenetic furrow seen in CycE^JP homozygotes.

(Secombe et al., 1998)

36% of ommatidia of rux³ are restored to wild type by stg^RXT13 or stg^AR2. Flies carrying rux⁸ in a heterozygous stg background show partial rescue of the rough-eye phenotype, but not the male sterility, at 18^oC.

(Thomas et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

stg^hwy

(Mozer and Easwarachandran, 1999)

Partially rescued by

stg^AR2 is partially rescued by stg^t31.6

(Lehman et al., 1999)

Comments

The postblastoderm cell division phenotype is partially rescued by stg^t31.6; cell cycle progression is seen in a subset of the wild-type division pattern.

(Lehman et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Transcriptional null allelle.

(Mozer and Easwarachandran, 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

stg^AR2

(Mitchell et al., 2008, Tanaka-Matakatsu et al., 2007, Heriche et al., 2003)

stg^ΔAR2

(Mozer and Easwarachandran, 1999)

string^AR2

(Thomsen et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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