FlyBase Allele Report: Dmel\sax[1rv1]

General Information

Symbol

Dmel\sax^1rv1

Species

D. melanogaster

Name

FlyBase ID

FBal0035535

Feature type

allele

Associated gene

Dmel\sax

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Twombly et al., 2009, Brummel et al., 1994)

Mutagen

gamma ray

(Twombly et al., 2009)

Progenitor genotype

sax¹

(Twombly et al., 2009)

Cytology

Polytene chromosomes normal

(Twombly et al., 2009)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)H23)

(Twombly et al., 2009)

lethal (with Df(2R)sax-H9)

(Twombly et al., 2009)

lethal (with sax³)

(Twombly et al., 2009)

lethal (with sax⁵)

(Twombly et al., 2009)

lethal (with sax⁶)

(Twombly et al., 2009)

lethal | larval stage (with sax⁴)

(Twombly et al., 2009)

lethal | maternal effect (with Df(2R)H23)

(Twombly et al., 2009)

lethal | maternal effect (with sax²)

(Twombly et al., 2009)

lethal | P-stage (with sax⁴)

(Twombly et al., 2009)

lethal | recessive

(Brummel et al., 1994)

partially lethal - majority die (with sax^P)

(Twombly et al., 2009)

viable (with sax¹)

(Twombly et al., 2009)

viable (with sax²)

(Twombly et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

sax^1rv1/sax² females exhibit a maternal effect lethal phenotype comparable to Df(2R)H23/sax² females. sax^1rv1 is zygotic lethal in trans over Df(2R)H23 or Df(2R)sax-H9. sax³ exhibits a very low level of viability in trans to sax^1rv1.

(Twombly et al., 2009)

Larval/pupal lethality can be rescued by sax^hs.PB. A low level of rescue is seen even without heat shock. sax^1rv1/Df(2R)sax-H30 are rescued to viability with an efficiency of 8-16% by tkv^Ubi-p63E.PB.

(Brummel et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(2L)JS17/+, sax^1rv1 has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^hr4/dpp[+], sax^1rv1 has partially lethal - majority live | dominant | maternal effect phenotype

(Twombly et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Df(2L)JS17 +/+ sax^1rv1 trans-heterozygotes exhibit a maternal effect lethal phenotype.

When sax^1rv1/+ females are crossed to dpp^hr4/+ males, the resulting dpp^hr4/+ progeny show a moderate drop in viability compared to the dpp^hr4/+ progeny of wild-type mothers in control crosses.

(Twombly et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

sax^1rv1/Df(2R)sax-H9 is rescued by sax^hs.PB

(Twombly et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sax^1rv1

(Twombly et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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