FlyBase Allele Report: Dmel\sax[hs.PB]

General Information

Symbol

Dmel\sax^hs.PB

Species

D. melanogaster

Name

heat shock construct of Brummel

FlyBase ID

FBal0035539

Feature type

allele

Associated gene

Dmel\sax

Associated Insertion(s)

Carried in Construct

P{hs-sax}

Key Links

Transgenic product class

cDNA

(Brummel et al., 1994)

wild_type

(Brummel et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Brummel et al., 1994)

wild_type

(Brummel et al., 1994)

Mutagen

in vitro construct

(Brummel et al., 1994)

Progenitor genotype

Carried in construct

P{hs-sax}

Cytology

Description

sax cDNA, driven by an Hsp70 promoter.

(Brummel et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

sax

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Females deficient for ovarian sax function produce two classes of abnormal eggs. The majority class has abnormal dorsal appendages, the minority class shows reduced egg length as well as abnormal dorsal appendages.

(Twombly et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

sax^hs.PB rescues sax⁴/Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB rescues sax³/Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB rescues Df(2R)sax-H9/sax⁵

(Twombly et al., 2009)

sax^hs.PB rescues sax⁶/Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB rescues Df(2R)H23/sax^PE5

(Twombly et al., 2009)

sax^hs.PB rescues sax^PE10/Df(2R)H23

(Twombly et al., 2009)

sax^hs.PB rescues sax^1rv1/Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB rescues sax^1rv5/Df(2R)sax-H9

(Twombly et al., 2009)

Fails to rescue

sax^hs.PB fails to rescue Df(2R)H23

(Twombly et al., 2009)

sax^hs.PB fails to rescue Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB fails to rescue Df(2R)sax^1rv2/Df(2R)sax-H9

(Twombly et al., 2009)

sax^hs.PB fails to rescue Df(2R)H23/Df(2R)sax^PE7

(Twombly et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Rescues larval/pupal lethality of sax^1rv1. A low level of rescue is seen even without heat shock.

(Brummel et al., 1994)

Used to generate flies with loss of function sax in the ovaries, by rescuing the zygotic lethality of sax alleles then maintaining the females at non-heat shock temperatures.

(Twombly et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sax^hs.PB

Name Synonyms

heat shock construct of Brummel

(Brummel et al., 1994)

Secondary FlyBase IDs

References (3)

Report Sections

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