FB2024_03 , released June 25, 2024
Allele: Dmel\tkv6
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General Information
Symbol
Dmel\tkv6
Species
D. melanogaster
Name
FlyBase ID
FBal0016823
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
Also Known As
tkvSz15
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chen et al., 1998, Singer et al., 1997, Terracol and Lengyel, 1994)
Mutagen
ethyl methanesulfonate
(Terracol and Lengyel, 1994)
Progenitor genotype
Cytology
Description

Splice acceptor mutation of CAG to CAA, in the extracellular domain.

(Penton et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,221,401..5,221,401 [-]
Nucleotide change:

G5221401A

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Splice acceptor mutation of CAG to CAA, affecting C75 and K76 (figure 1).

(Penton et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes have thickened wing veins. All other imaginal disc-derived structures appear normal. tkv6/Df(2L)tkv2 flies are phenotypically identical to tkv6 homozygotes. tkvD17/tkv6 flies have defects in the notum and legs. tkv6/tkv6 embryos form three midgut constrictions.

      (Chen et al., 1998)

      Clones within an adult wing that intersects the margin causes formation of triple row in an area that normally produces dorsal row.

      (Singer et al., 1997)

      Homozygotes display weak head defects, wrinkled dorsal epidermis and internalised and often disorganised filzkorper. Lethal when heterozygous with tkv4, tkv5, tkv7 and tkv8, but not with Df(2L)tkv2. Female transheterozygotes with Df(2L)tkv2 are viable and display a wing phenotype, wing veins are very thick and short along the proximal distal axis, transheterozygotes with Df(2L)tkv3 display wing veins that are very thick and short along the proximal distal axis. Adult Df(2L)tkv3/tkv6 and tkv1/tkv6 females lay eggs, some of the embryos from these females crossed to wild type males die showing a weakly ventralised phenotype.

      (Terracol and Lengyel, 1994)

      Viable with strong tkv phenotype over Tp(2;3)tkv (Szidonya and Reuter, 1988). homozygous lethal; hemizygous viable with thick veins;

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      MadD14, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      MadD3, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      gbbD8, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      MedD5, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      gbbD20, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has lethal | recessive | embryonic stage phenotype

      (Chen et al., 1998)

      MadD15, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      gbbD8, tkv6 has lethal | recessive | embryonic stage phenotype

      (Chen et al., 1998)

      putD13, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      putD18, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      shn1, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      putD13, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      E(tkv)D1D1, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      E(tkv)D2D2, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MadD3, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MadD14, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MadD15, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MadD16, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MadD16, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      MadD24, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      gbbD8, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      gbbD20, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      MedD5, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      putD18, tkv6 has visible | recessive phenotype

      (Chen et al., 1998)

      gbbD8/gbbD4, tkv6 has lethal | recessive | embryonic stage phenotype

      (Chen et al., 1998)

      MadD24, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      E(tkv)D2D2, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)

      E(tkv)D1D1, tkv6 has visible | dominant phenotype

      (Chen et al., 1998)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      tkv6 has phenotype, enhanceable by put135

      (Chen et al., 1998)
      Enhancer of
      Statement
      Reference

      tkv6 is an enhancer of embryonic midgut constriction phenotype of gbbD8/gbbD4

      (Chen et al., 1998)
      Other
      Statement
      Reference

      MadD14, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MadD24, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MadD24, tkv6 has leg phenotype

      (Chen et al., 1998)

      MadD3, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MadD3, tkv6 has leg phenotype

      (Chen et al., 1998)

      MedD5, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MedD5, tkv6 has leg phenotype

      (Chen et al., 1998)

      gbbD20, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MadD14, tkv6 has leg phenotype

      (Chen et al., 1998)

      gbbD20, tkv6 has leg phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has sex comb | ectopic phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has tarsal segment phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has scutum phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has leg phenotype

      (Chen et al., 1998)

      gbbD4, tkv6 has unguis phenotype

      (Chen et al., 1998)

      gbbD8, tkv6 has scutum phenotype

      (Chen et al., 1998)

      gbbD8, tkv6 has leg phenotype

      (Chen et al., 1998)

      putD13, tkv6 has scutum phenotype

      (Chen et al., 1998)

      putD13, tkv6 has leg phenotype

      (Chen et al., 1998)

      shn1, tkv6 has tarsal segment phenotype

      (Chen et al., 1998)

      MadD15, tkv6 has scutum phenotype

      (Chen et al., 1998)

      shn1, tkv6 has leg phenotype

      (Chen et al., 1998)

      shn1, tkv6 has wing vein phenotype

      (Chen et al., 1998)

      shn1, tkv6 has unguis phenotype

      (Chen et al., 1998)

      E(tkv)D1D1, tkv6 has scutum phenotype

      (Chen et al., 1998)

      E(tkv)D2D2, tkv6 has scutum phenotype

      (Chen et al., 1998)

      MadD15, tkv6 has leg phenotype

      (Chen et al., 1998)

      MadD16, tkv6 has scutum phenotype

      (Chen et al., 1998)

      putD18, tkv6 has scutum phenotype

      (Chen et al., 1998)

      putD18, tkv6 has leg phenotype

      (Chen et al., 1998)

      MadD16, tkv6 has leg phenotype

      (Chen et al., 1998)

      gbbD8/gbbD4, tkv6 has embryo phenotype

      (Chen et al., 1998)

      gbbD8/gbbD4, tkv6 has embryonic/first instar larval cuticle phenotype

      (Chen et al., 1998)

      gbbD8/gbbD4, tkv6 has embryonic head phenotype

      (Chen et al., 1998)

      E(tkv)D2D2, tkv6 has mesothoracic bristle phenotype

      (Chen et al., 1998)

      E(tkv)D1D1, tkv6 has mesothoracic bristle phenotype

      (Chen et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      shn1 dominantly enhances the wing vein defects of tkv6 flies, and also produces defects in proximal/distal patterning of the leg in these flies; distal elements such as claws and distal tarsal segments are deleted in tkv6 shn1; tkv6 flies. The phenotype is dominantly enhanced by E(tkv)D1D1 or E(tkv)D2D2; tkv6 flies carrying one copy of E(tkv)D1D1 or E(tkv)D2D2 have defects in the notum. The phenotype is dominantly enhanced by MadD3, MadD14, MadD15, MadD16, MadD24, gbbD4, gbbD8, gbbD20, MedD5, putD13 or putD18; tkv6 flies carrying one copy of MadD3, MadD14, MadD15, MadD16, MadD24, gbbD4, gbbD8, gbbD20, MedD5, putD13 or putD18 have defects in the notum and legs. No interaction with dpps5, shn1, sax5, MadP1, MadP1 or put135 is seen in double heterozygous flies. tkv6 gbbD4/tkv6 gbbD8 embryos form only one midgut constriction. gbbD4/tkv6 gbbD8 embryos have head defects and an excessive ventral curvature. gbbD4/tkv6 gbbD8 embryos derived from homozygous tkv6 females have a dorsal open phenotype.

      (Chen et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Szidonya.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tkv6
      (Makhijani et al., 2007)
      tkvSz15
      (Terracol and Lengyel, 1994)
      tkvsz15
      (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)