FlyBase Allele Report: Dmel\sw[1]

General Information

Symbol

Dmel\sw¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016648

Feature type

allele

Associated gene

Dmel\sw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with sw¹²²⁹)

(Zheng et al., 2008)

abnormal neuroanatomy | temperature conditional

(Wang et al., 2015)

lethal (with sw²)

(Lindsley and Zimm, 1992)

lethal (with sw⁵)

(Lindsley and Zimm, 1992)

lethal (with sw⁶)

(Lindsley and Zimm, 1992)

lethal (with sw⁷)

(Lindsley and Zimm, 1992)

lethal | heat sensitive (with Df(1)mal3)

(Boylan and Hays, 2002)

lethal - all die before end of pupal stage (with sw¹⁵)

(Lindsley and Zimm, 1992)

semi-fertile

(Boylan and Hays, 2002)

some die during pupal stage (with sw¹⁵)

(Lindsley and Zimm, 1992)

viable

(Boylan and Hays, 2002)

visible

(Boylan and Hays, 2002)

visible (with sw^Dic-1)

(Boylan and Hays, 2002)

visible (with sw^Dic-2)

(Boylan and Hays, 2002)

visible (with sw^Dic-3)

(Boylan and Hays, 2002)

Phenotype Manifest In

cystic bulge

(Ghosh-Roy et al., 2005)

dendritic arborizing neuron (with sw¹²²⁹)

(Zheng et al., 2008)

eye

(Boylan and Hays, 2002, Lindsley and Zimm, 1992, Schalet and Finnerty, 1968)

larval multidendritic class I neuron | temperature conditional

(Wang et al., 2015)

nucleus & spermatid

(Ghosh-Roy et al., 2005)

ommatidium

(Boylan and Hays, 2002)

wing

(Lindsley and Zimm, 1992, Mortin and Lefevre, 1981, Schalet and Finnerty, 1968)

wing (with sw^Dic-1)

(Boylan and Hays, 2002)

wing (with sw^Dic-2)

(Boylan and Hays, 2002)

wing (with sw^Dic-3)

(Boylan and Hays, 2002)

wing margin

(Hain et al., 2014, Boylan and Hays, 2002)

wing vein

(Hain et al., 2014, Boylan and Hays, 2002)

Detailed Description

Statement

Reference

Class I dendritic arborizing neurons in sw¹/+ larvae raised at 25[o]C become bipolar, as compared to multipolar in wild type, but do not display a change in the number of dendritic branches.

(Wang et al., 2015)

A low percentage of sw¹ flies exhibit partial deletion of wing margins, particularly at the posterior, and defective wing venation.

(Hain et al., 2014)

Dendritic arborization neurons show an altered distribution of Golgi outposts in sw¹²²⁹/sw¹ larvae compared to controls. Golgi outposts can be seen moving from the soma into the axon and travelling anterogradely and retrogradely within the axon.

(Zheng et al., 2008)

About 60% of the actin nuclear bundles and individualization complexes are disrupted in the testis of sw¹ hemizygous males. The F-actin density in the investment cones is not significantly different from wild-type spermatids.

(Ghosh-Roy et al., 2005)

sw^Dic-2/sw¹ flies have a mild wing phenotype at 28^oC. Mutant flies have a variable wing phenotype, including defects in wing venation and incised margins, reduced fertility and rough eyes.

(Boylan and Hays, 2002)

Above 23^oC, most sw¹ flies have spread and incised wings with irregular veins; eyes reduced and roughened. Male expression more extreme than female. RK2 at 28^oC.

(Lindsley and Zimm, 1992)

+/Df(1)mal10 and +/sw¹ exhibit short-wing phenotype in presence of RpII215^Ubl.

(Mortin and Lefevre, 1981)

15% of males eclose at 25^oC; show wing and eye abnormalities; above 31^oC, sw¹ is lethal. At 17^oC, most flies are wild type; at 14^oC, all are wild type.

(Schalet and Finnerty, 1968)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sw¹/sw[+] is an enhancer of visible | dominant phenotype of DCTN1-p150^Gl-1

(Boylan and Hays, 2002)

Suppressor of

Statement

Reference

sw¹/sw[+] is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

Other

Statement

Reference

ctp^DIIA82, sw¹ has lethal phenotype

(Ghosh-Roy et al., 2005)

ctp^ins1, sw¹ has lethal phenotype

(Ghosh-Roy et al., 2005)

DCTN1-p150^Gl-1, sw¹ has lethal phenotype

(Boylan and Hays, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sw¹ has wing margin phenotype, enhanceable by dop¹/dop¹

(Hain et al., 2014)

sw¹ has wing vein phenotype, enhanceable by dop¹/dop¹

(Hain et al., 2014)

sw¹ has wing margin phenotype, enhanceable by dop[+]/dop¹

(Hain et al., 2014)

sw¹ has cystic bulge phenotype, enhanceable by ctp^exc39

(Ghosh-Roy et al., 2005)

sw¹ has nucleus & spermatid phenotype, enhanceable by ctp^exc39

(Ghosh-Roy et al., 2005)

NOT Enhanced by

Statement

Reference

sw¹ has wing vein phenotype, non-enhanceable by dop[+]/dop¹

(Hain et al., 2014)

Enhancer of

Statement

Reference

sw¹/sw¹ is an enhancer of wing margin phenotype of dop¹

(Hain et al., 2014)

sw¹/sw¹ is an enhancer of wing vein phenotype of dop¹

(Hain et al., 2014)

sw¹ is an enhancer of membrane | embryonic stage 5 phenotype of dop¹

(Hain et al., 2014)

sw¹/sw[+] is an enhancer of ommatidium phenotype of DCTN1-p150^Gl-1

(Boylan and Hays, 2002)

Suppressor of

Statement

Reference

sw¹/sw[+] is a suppressor | partially of neurite | increased number phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

sw¹/sw[+] is a suppressor | partially of dendrite | increased number phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

sw¹/sw[+] is a suppressor | partially of dendrite | increased number phenotype of Scer\GAL4^P2.4.Pdf, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

sw¹/sw[+] is a suppressor | partially of adult Pdf neuron phenotype of Scer\GAL4^P2.4.Pdf, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

sw¹/sw[+] is a suppressor | partially of embryonic/larval motor neuron phenotype of Scer\GAL4^eve.RN2, dar1^{UAS.Tag:V5,Tag:polyHis}

(Wang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The supernumerary dendrite phenotype seen in animals expressing dar1^Scer\UAS.cYa under the control of Scer\GAL4^eve.RN2 (in unipolar motor neurons) or Scer\GAL4^P2.4.Pdf (in adult unipolar PDF neurons) is greatly reduced in sw¹/+ mutants.

(Wang et al., 2015)

The wing margin and wing vein defects of sw¹ dop¹ double mutants are more severe than either single mutant, sometimes resulting in 'crippled' wings.

The defect in membrane growth in dop¹ embryos is strongly enhanced by sw¹.

(Hain et al., 2014)

ctp^exc39; sw¹/Y mutants are viable at 25^oC. The double mutants show a slight enhancement of the disruption of individualization complexes seen in both single mutants.

Almost all ctp^ins1; sw¹/Y and ctp^DIIA82; sw¹/Y males fail to emerge, at either 25^oC or 18^oC.

(Ghosh-Roy et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

sw³

(Lindsley and Zimm, 1992)

Fails to complement

sw^Dic-1

(Boylan and Hays, 2002)

sw^Dic-2

(Boylan and Hays, 2002)

sw^Dic-3

(Boylan and Hays, 2002)

Rescued by

sw¹ is rescued by sw^+t11

(Boylan and Hays, 2002)

sw¹/sw^Dic-1 is rescued by sw^+t11

(Boylan and Hays, 2002)

sw^Dic-2/sw¹ is rescued by sw^+t11

(Boylan and Hays, 2002)

sw¹/sw^Dic-3 is rescued by sw^+t11

(Boylan and Hays, 2002)

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (3)

Bloomington

4175

sw¹

175

Df(1)os^o, y¹ pn¹ w¹ cm¹ ct⁶ sn³ oc¹ ras² v¹ dy¹ g² f¹ upd1^os-o upd3^os-o car¹ sw¹/FM0

Kyoto

105772

Df(1)os^o, y¹ pn¹ w¹ cm¹ ct⁶ sn³ oc¹ ras² v¹ dy¹ g² f¹ upd1^os-o upd3^os-o car¹ sw¹/In(1)sc^S1, In(1)dl-49, y^c4 sc^S1 v^Of Bar¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dic^ts

(Zheng et al., 2008)

sw¹

(Hain et al., 2014, Cook and Cook, 2010.2.17, Xiong et al., 2010, Christensen et al., 2008.10.20, Cook et al., 2008.9.3, Cook et al., 2008.9.3, Ghosh-Roy et al., 2005)

sw^ts

(Wang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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