FlyBase Allele Report: Dmel\oc[1]

General Information

Symbol

Dmel\oc¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013199

Feature type

allele

Associated gene

Dmel\oc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(1)oc

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eclosion rhythm

(McNabb and Truman, 2008)

abnormal locomotor behavior

(Martin et al., 1999)

female sterile

(Gordesky-Gold et al., 1995)

visible

(Royet and Finkelstein, 1995)

visible | recessive

(Adachi et al., 2001, Nagao et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

The eclosion of oc¹ mutant flies under photoperiod conditions lacks the prominent lights-on response seen in wild-type flies. No significant increases in eclosion are seen regardless of when flies are exposed to the lights-on signal. The eclosion rate is variable and substantial eclosion precedes the lights-on signal, but overall eclosion appears circadian. Flies exhibit normal geotaxis. The time taken for the flies to spread their wings post-eclosion is similar in flies that eclose in the dark and those that eclose in response to the lights-on signal. This is in contrast to controls, in which inflation occurs more quickly in the dark.

(McNabb and Truman, 2008)

oc¹ males do not show feminisation of walking behaviour; the number of start/stop bouts is not greater than in control males.

(Belgacem and Martin, 2002)

Homozygotes and hemizygotes lack ocelli and most of the associated bristles.

(Adachi et al., 2001)

The entire protocerebral bridge is missing in oc¹ adult brains. Total walking activity is significantly decreased in comparison to wild-type flies. Episodes of high walking probability occur as frequently as in wild-type flies, but these episodes are of much shorter duration than in wild type.

(Martin et al., 1999)

Homozygotes and hemizygotes lack the ocelli and most of the associated bristles.

(Nagao et al., 1998)

Transheterozygous larvae with lphA² have a low negatively photokinetic stimulus indice.

(Gordesky-Gold et al., 1995)

Defects in formation of the protocerebral bridge.

(Hirth et al., 1995)

In hemizygotes the ocelli, the interocellar, ocellar and postvertical bristles are missing, only disorganised macrochaetae are present in this region. Medial portion of the frons is missing so a few lateral ridges of frons cuticle remain. One hour heat pulse of P{HS-en.G} at 100 hours AEL in oc¹ individuals causes the reappearance of ocelli. Phenotypic series from the strongest to weakest oc allele: oc^db/oc^db > oc¹/oc⁺ > oc^γa1/oc⁺ > oc²/oc⁺ > oc¹/oc¹ > oc^γa1/oc^γa1 > oc²/oc¹ > oc²/oc^γa1.

(Royet and Finkelstein, 1995)

Adult flies have defects in the ocellar region of the head capsule. oc¹/oc^γa1 transheterozygotes have slightly stronger defects. The ocelli and much of the adjacent cuticle is missing. The frons region lacks its typical ridged morphology and has ectopic bristles. oc¹/oc^γa1 transheterozygotes also variably lack parovaria. Clones in the head homozygous for oc¹ show abnormal morphology only when located in the medial region (the ocellar and occipital regions and the frons).

(Wieschaus et al., 1992)

female-sterile Eggs from oc¹ homozygotes have defective chorions and abnormal β yolk spheres (Johnson and King, 1974). Sterility is due to the presence of In(1)oc, one breakpoint of which disrupts oc and the other of which interferes with amplification of the chorion-protein genes Cp36 and Cp38 (Spradling and Mahowald, 1981). oc¹ in heterozygous combination with non-complementing lethal alleles survives and is female fertile.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

oc¹ has visible | recessive phenotype, suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc¹ has visible | recessive phenotype, suppressible by Hsap\OTX1^hs.PN

(Adachi et al., 2001, Nagao et al., 1998)

oc¹ has visible | recessive phenotype, suppressible by Hsap\OTX2^hs.PN

(Nagao et al., 1998)

Suppressor of

Statement

Reference

oc¹ is a suppressor of abnormal locomotor behavior | male phenotype of Scer\GAL4^103Y, tra^UAS.cFa

(Belgacem and Martin, 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

oc¹ has ocellar bristle phenotype, suppressible by Hsap\OTX1^hs.PN

(Adachi et al., 2001)

oc¹ has ocellus phenotype, suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc¹ has ocellus phenotype, suppressible by Hsap\OTX1^hs.PN

(Adachi et al., 2001)

oc¹ has ocellus pigment granule phenotype, suppressible by Hsap\OTX1^hs.PN

(Nagao et al., 1998)

oc¹ has ocellus lens phenotype, suppressible by Hsap\OTX1^hs.PN

(Nagao et al., 1998)

oc¹ has adult head bristle phenotype, suppressible by Hsap\OTX1^hs.PN

(Nagao et al., 1998)

oc¹ has ocellus pigment granule phenotype, suppressible by Hsap\OTX2^hs.PN

(Nagao et al., 1998)

oc¹ has ocellus lens phenotype, suppressible by Hsap\OTX2^hs.PN

(Nagao et al., 1998)

oc¹ has adult head bristle phenotype, suppressible by Hsap\OTX2^hs.PN

(Nagao et al., 1998)

NOT suppressed by

Statement

Reference

oc¹ has ocellar bristle phenotype, non-suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc¹ has postocellar bristle phenotype, non-suppressible by Hror\Otx^hs.PA

(Adachi et al., 2001)

oc¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

Males expressing tra^Scer\UAS.cFa under the control of Scer\GAL4^103Y in an oc¹ background do not show feminisation of walking behaviour; the number of start/stop bouts is not greater than in control males.

(Belgacem and Martin, 2002)

Xenogenetic Interactions

Statement

Reference

Hror\Otx^hs.PA partially rescues the vertex defects of oc¹ adults; rescue of ocellus lens structures but not of ocellar or postvertical bristles is seen. Hsap\OTX1^hs.PN partially rescues the vertex defects of oc¹ adults; 16.1% rescue of ocellus lens structures and some rescue of ocellar but not postvertical bristles is seen.

(Adachi et al., 2001)

The phenotype is also complemented by Hsap\OTX1^hs.PN or by Hsap\OTX2^hs.PN; oc¹ flies carrying either of these alleles have either ocellar lenses and/or associated ocellar pigments. The number of macrochaetae on the vertex of the head is also rescued towards wild-type in these flies.

(Nagao et al., 1998)

Complementation and Rescue Data

Partially rescued by

oc¹ is partially rescued by oc^hs.PR

(Adachi et al., 2001)

oc¹ is partially rescued by oc^hs.PR

(Nagao et al., 1998)

Comments

The ocellus phenotype is partially rescued by oc^hs.PR, rescue being most effective when heat pulses are applied either 72-85 hours after egg laying (AEL) or 84-97 hours AEL, and being virtually ineffective when heat pulses are given at the end of the third larval instar stage.

(Nagao et al., 1998)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (40)

Bloomington

ctⁿ oc¹/FM1

1899

oc¹ ptg¹/C(1)DX, y¹ f¹

5266

FM7d, oc¹ ptg¹/C(1)DX, y¹ f¹

5267

FM7d, P{ftz-lacC}YH1, oc¹ ptg¹/C(1)DX, y¹ f¹

3896

C(1)DX, y¹ f¹/Sxl^f1 oc¹ ptg¹ v¹

Kyoto

105683

ctⁿ oc¹/FM1

108135

FM7d, oc¹ ptg¹/C(1)DX, y¹ f¹

101035

C(1)DX, y¹ w¹ f¹ / sn³ oc¹

108137

FM7d, w¹ oc¹ ptg¹/C(1)DX, y¹ f¹

108136

FM7d, P{ftz-lacC}YH1, oc¹ ptg¹/C(1)DX, y¹ f¹

107615

w¹ sn¹ oc¹ ptg¹/C(1)DX, y¹ f¹

107256

C(1)DX, y¹ f¹/Sxl^f1 oc¹ ptg¹ v¹

More stocks available...

Notes on Origin

Discoverer

Bedichek, 15th March 1930.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

oc¹

(Popodi et al., 2010-, Venken et al., 2010, Blanco et al., 2009, Cook et al., 2008.9.3, Cook et al., 2008.9.29, Hong et al., 2008, McNabb and Truman, 2008, Carr et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (29)

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