FB2024_03 , released June 25, 2024
Aberration: Dmel\In(1)oc
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General Information
Symbol
In(1)oc
Species
D. melanogaster
Name
Inversion (1) ocelliless
FlyBase ID
FBab0004161
Feature type
chromosomal_inversion
Computed Breakpoints include

7F1-7F2;8A1-8A2

Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_inversion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_inversion
Breakpoints
Causes alleles
oc1
(Blanco et al., 2009, Wieschaus et al., 1992)
Carries alleles
Transposon Insertions
Formalized genetic data

bk2 hits oc

Genetic mapping information
Comments

Breakpoint 2 was linked to a EcoRI-EcoRI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Finkelstein et al., 1990)

Breakpoint(s) molecularly mapped

(Finkelstein et al., 1990, Parks et al., 1986, Spradling and Mahowald, 1981, Spradling et al., 1979)

Sequences containing both breakpoints as well as adjacent sequences cloned. Inversion shows drastically altered pattern of differential replication of sequences surrounding 7F1-2; the 40 kb of DNA lying distal to the 7F breakpoint do not amplify as in the normal X; the remaining 50 kb, now adjacent to 8A, show somewhat reduced amplification. Sequences proximal to the 8A breakpoint do amplify in In(1)oc-containing follicle cells. Region 7F seems to contain a replication origin stimulated to additional rounds of replication.

Comments on Cytology

Limits of break 1 from polytene analysis (citation unavailable) Limits of break 2 from complementation mapping against oc (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Nrg
(Kerr et al., 1997)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Homozygous females sterile, but sterility may not be due to mutation at oc since ocl/oc females are fertile (Lefevre). Cp36 and Cp38 are included within and 1-3 kb from the distal breakpoint of the inversion. Synthesis of chorion proteins s36-1 and s36-2 much reduced in homozygotes (Spradling et al., 1979). Abnormal ultrastructure of chorion described by Johnson and King (1974).

    Stocks (0)
    Notes on Origin
    Discoverer

    Bedichek, 15th March 1930.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Two phenotypic defects are separable: female sterile defect is associated with 7F1-7F2 breakpoint and the oc defect with the 8A breakpoint.

    (Spradling et al., 1994)
    Synonyms and Secondary IDs (6)
    Reported As
    Symbol Synonym
    In(1)oc
    In(1)oc1
    (Kerr et al., 1997)
    In(1)Δ49
    (Finkelstein et al., 1990)
    In(1)Δ49 oc
    (Blanco et al., 2009)
    Δ49
    (Takeuchi et al., 2007)
    Name Synonyms
    Inversion (1) ocelliless
    Secondary FlyBase IDs
      References (13)