FlyBase Allele Report: Dmel\tws[02414]

General Information

Symbol

Dmel\tws⁰²⁴¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0009447

Feature type

allele

Associated gene

Dmel\tws

Associated Insertion(s)

P{PZ}tws⁰²⁴¹⁴

Carried in Construct

Also Known As

l(3)02414

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}tws⁰²⁴¹⁴

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:10,133,206..10,133,206 [+]

(Bánréti et al., 2012, Andrade et al., 2003.7.4, Spradling et al., 1999, Harvie et al., 1998, Maixner et al., 1998, Braun et al., 1997, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | maternal effect

(Perrimon et al., 1996)

lethal | recessive

(Kotadia et al., 2008, Spradling et al., 1999, Harvie et al., 1998, Perrimon et al., 1996)

lethal - all die during embryonic stage

(Wang et al., 2009)

some die during embryonic stage

(Wang et al., 2009)

Phenotype Manifest In

abdomen | maternal effect

(Perrimon et al., 1996)

neuroblast (with tws⁶⁰)

(Wang et al., 2009)

Detailed Description

Statement

Reference

Starvation induced formation of lysosomes/autolysosomes is normal in mutant larvae.

(Bánréti et al., 2012)

The mitotic spindle is misaligned with the cortical crescent in some tws⁰²⁴¹⁴/tws⁶⁰ neuroblasts.

(Wang et al., 2009)

Germline clones produce eggs with patterning defects: embryos have no abdominal segments.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tws[+]/tws⁰²⁴¹⁴ is an enhancer of lethal | embryonic stage phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

Suppressor of

Statement

Reference

tws⁰²⁴¹⁴ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

NOT Suppressor of

Statement

Reference

tws[+]/tws⁰²⁴¹⁴ is a non-suppressor of abnormal cell migration | oogenesis phenotype of Scer\GAL4^c306, cactin^KK100507

(Miao et al., 2022)

Other

Statement

Reference

Ras85D^V12.sev, sev^S11.Tag:MYC, tws⁰²⁴¹⁴ has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

tws[+]/tws⁰²⁴¹⁴ is an enhancer of centrosome | increased number phenotype of SV40\ST^{UASp.Tag:FLAG}, Scer\GAL4^{VP16.nanos.UTR}

(Kotadia et al., 2008)

NOT Suppressor of

Statement

Reference

tws[+]/tws⁰²⁴¹⁴ is a non-suppressor of border follicle cell phenotype of Scer\GAL4^c306, cactin^KK100507

(Miao et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by tws⁰²⁴¹⁴.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tws^s1801

(BDGP Project Members, 1994-1999)

tws^j11C8

(BDGP Project Members, 1994-1999)

tws⁰⁶⁸⁴⁸

(BDGP Project Members, 1994-1999)

tws⁰⁴⁰¹⁷

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11568

P{PZ}tws⁰²⁴¹⁴ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Kyoto

108872

P{PZ}tws⁰²⁴¹⁴ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: knk^ex59.

(Beitel and Krasnow, 2000)

Complements: l(3)j9A5^j9A5.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(3)02414

(Spradling et al., 1999, Maixner et al., 1998)

tws⁰²⁴¹⁴

(Miao et al., 2022, Johns et al., 2018, Chabu and Doe, 2009, Wang et al., 2009, Cai et al., 2008, Christensen et al., 2008.6.11, Cook et al., 2008.9.29)

tws⁰²⁴²⁴

(Wang et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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