FlyBase Allele Report: Dmel\fz[1]

General Information

Symbol

Dmel\fz¹

Species

D. melanogaster

Name

FlyBase ID

FBal0004917

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Park et al., 1994)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Lee and Adler, 2002, Taylor et al., 1998)

abnormal planar polarity | cell non-autonomous | somatic clone

(Lee and Adler, 2002)

visible

(Adler et al., 1994)

Phenotype Manifest In

bract

(Lee and Adler, 2002)

eye

(Lee and Adler, 2002)

larval RP2 motor neuron

(Bhat, 1998)

leg joint

(Lee and Adler, 2002)

macrochaeta & adult abdomen | somatic clone | cell non-autonomous

(Lee and Adler, 2002)

microchaeta & adult abdomen | somatic clone | cell non-autonomous

(Lee and Adler, 2002)

microchaeta & adult thorax | somatic clone | cell non-autonomous

(Lee and Adler, 2002)

ommatidium

(Lee and Adler, 2002)

presumptive embryonic salivary gland

(Harris and Beckendorf, 2007)

tarsal segment

(Lee and Adler, 2002)

wing & macrochaeta

(Adler et al., 1994)

wing disc

(Lee and Adler, 2002)

wing hair

(Taylor et al., 1998)

Detailed Description

Statement

Reference

Mutant embryos show salivary gland guidance defects; a large portion of the salivary gland curves towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.

(Harris and Beckendorf, 2007)

When mutant clones are made in the developing eye, no R-cell precursor nuclear migration phenotype was seen.

(Houalla et al., 2005)

Bristles and hairs on the adult abdomen and thorax show altered polarity. Clones reveal the effect shows domineering non-autonomy. fz¹ phenotypes differ from in¹ and fy¹ in two ways. In fz¹ the hairs on the scutellum show a complicated pattern rather than pointing anteriorly, and thorax microchaetae are not routinely split. On the leg, femoral bracts are mispositioned indicating abnormal polarity. Tarsal segments may have parts missing and/or duplicated and show cuticular blebs. Eyes show a rough eye phenotype due to ommatidial disorganisation. Pupal wings show miseversion phenotype - many pupae show an everting wing oriented anteriorly and sometimes dorsally.

(Lee and Adler, 2002)

Embryos lacking maternal and zygotic fz function (derived from a cross between fz¹/fz³⁰ males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 10% of cases. Embryos lacking maternal and zygotic fz function (derived from a cross between fz¹/fz²³ males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 11% of cases.

(Bhat, 1998)

Homozygous embryos derived from homozygous females have a negligible segment-polarity phenotype. Injection of dsRNA produced by annealing fz2^L.cKa and fz2^a.L.cKa RNA into these embryos results in segment polarity phenotypes.

(Kennerdell and Carthew, 1998)

Bristle polarity phenotype.

(Adler et al., 1994)

moderate thoracic bristle phenotype moderate wing-hair disorientation

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

fz¹/fz¹ is a non-enhancer of visible | adult stage phenotype of in¹

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of abnormal planar polarity | adult stage phenotype of in¹

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of visible | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of abnormal planar polarity | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of visible | adult stage phenotype of fy²

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of abnormal planar polarity | adult stage phenotype of fy²

(Wang et al., 2017)

fz¹ is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of mud³

(Cate et al., 2016)

fz¹ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

fz[+]/fz¹ is a suppressor | partially of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

fz[+]/fz¹ is a suppressor | partially of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

fz¹ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Other

Statement

Reference

Df(1)NetAB^Δ, fz¹ has abnormal neuroanatomy | embryonic stage phenotype

(Cate et al., 2016)

fz3^G10, fz¹ has viable phenotype

(Sato et al., 1999)

fz3^G10, fz¹ has fertile phenotype

(Sato et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz¹ has presumptive embryonic salivary gland phenotype, enhanceable by drl^R343

(Harris and Beckendorf, 2007)

NOT Enhanced by

Statement

Reference

fz¹ has bract phenotype, non-enhanceable by fy¹

(Lee and Adler, 2002)

fz¹ has leg joint phenotype, non-enhanceable by fy¹

(Lee and Adler, 2002)

fz¹ has tarsal segment phenotype, non-enhanceable by fy¹

(Lee and Adler, 2002)

fz¹ has bract phenotype, non-enhanceable by in¹

(Lee and Adler, 2002)

fz¹ has leg joint phenotype, non-enhanceable by in¹

(Lee and Adler, 2002)

fz¹ has tarsal segment phenotype, non-enhanceable by in¹

(Lee and Adler, 2002)

Suppressed by

Statement

Reference

fz¹ has wing disc | P-stage phenotype, suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has wing disc | P-stage phenotype, suppressible by in¹

(Lee and Adler, 2002)

NOT suppressed by

Statement

Reference

fz¹ has ommatidium phenotype, non-suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has ommatidium phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

fz¹ has tarsal segment phenotype, non-suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has tarsal segment phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

fz¹ has microchaeta & adult thorax | somatic clone | cell non-autonomous phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

fz¹ has bract phenotype, non-suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has bract phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

fz¹ has eye phenotype, non-suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has eye phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

fz¹ has leg joint phenotype, non-suppressible by fy¹

(Lee and Adler, 2002)

fz¹ has leg joint phenotype, non-suppressible by in¹

(Lee and Adler, 2002)

Enhancer of

Statement

Reference

fz¹ is an enhancer of presumptive embryonic salivary gland phenotype of drl^R343

(Harris and Beckendorf, 2007)

NOT Enhancer of

Statement

Reference

fz¹/fz¹ is a non-enhancer of abdominal sternite bristle phenotype of in¹

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of abdominal sternite bristle phenotype of frtz³⁰

(Wang et al., 2017)

fz¹/fz¹ is a non-enhancer of abdominal sternite bristle phenotype of fy²

(Wang et al., 2017)

fz¹ is a non-enhancer of larval ventral nerve cord | embryonic stage phenotype of mud³

(Cate et al., 2016)

fz¹ is a non-enhancer of larval ventral nerve cord commissure | embryonic stage phenotype of mud³

(Cate et al., 2016)

fz¹ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

fz[+]/fz¹ is a suppressor | partially of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

fz¹ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

fz¹ is a non-suppressor of microchaeta & adult thorax phenotype of in¹

(Lee and Adler, 2002)

fz¹ is a non-suppressor of microchaeta & adult thorax phenotype of fy¹

(Lee and Adler, 2002)

fz¹ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

Other

Statement

Reference

Df(1)NetAB^Δ, fz¹ has larval ventral nerve cord | embryonic stage phenotype

(Cate et al., 2016)

Df(1)NetAB^Δ, fz¹ has larval ventral nerve cord commissure | embryonic stage phenotype

(Cate et al., 2016)

Df(3L)N2-27, fz¹ has larval RP2 motor neuron phenotype

(Bhat, 1998)

Vang^A3, fz¹ has wing hair phenotype

(Taylor et al., 1998)

Vang^A5, fz¹ has wing hair phenotype

(Taylor et al., 1998)

Vang^Tbs42, fz¹ has wing hair phenotype

(Taylor et al., 1998)

Scer\GAL4^hs.2sev, dsh^UAS.cNa, fz¹ has ommatidium phenotype

(Strutt et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

fy²;fz¹ double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in fy² single mutants and the severity of abdominal bristle polarity phenotype in¹,fz¹ double mutant is similar to in single mutants. The frtz³⁰;fz¹ double mutant have abdominal bristle defects that are comparable to frtz³⁰ single mutants.

(Wang et al., 2017)

fz¹, Df(1)NetAB^Δ double mutant embryos display a severe lack of commissures in the ventral nerve cord.

fz¹, mud³ mutant embryos do not display any more severe ventral nerve cord phenotypes, as compared to each single mutant.

(Cate et al., 2016)

drl^R343 ; fz¹ double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone.

(Harris and Beckendorf, 2007)

Domineering non-autonomy of fz¹ clones is not suppressed by in¹. Leg phenotypes of fz¹ and fy¹ or in¹ are additive.

(Lee and Adler, 2002)

Parp^GMR.PU shows no genetic interaction with fz¹/+.

(Uchida et al., 2002)

All fz¹/fz¹; Df(3L)N2-27 double mutant embryos show RP2/sib lineage defects, with 6-11 hemisegments per embryo being affected.

(Bhat, 1998)

In double mutant combinations between Vang^A3, Vang^A5 and Vang^Tbs42 with fz¹, fz²⁵ and fz³⁰, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^hs.2sev/fz¹ partially rescues fz^UAS.cAa

(Strutt et al., 1997)

Comments

fz¹ somatic clones in the eye in a fz^{sevE3.SevP.PS} background: In the center of clones, 15%-25% of ommatidia showed dorso-ventral inversions, as observed in eyes wholly mutant for fz in a fz^{sevE3.SevP.PS} background. However, on the polar edge of the clone, 40%-60% of ommatidia are inverted, whereas, on the equatorial edge, only 5% are inverted. These inversions are also seen on outside the clone, near its polar boundary.

(Strutt and Strutt, 2002)

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

1676

fz¹/TM1

5408

w^*; l(3)SG11¹ fz¹/TM6B, Tb¹

Kyoto

106445