FlyBase Allele Report: Dmel\Vang[Tbs42]

General Information

Symbol

Dmel\Vang^Tbs42

Species

D. melanogaster

Name

FlyBase ID

FBal0045270

Feature type

allele

Associated gene

Dmel\Vang

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Taylor et al., 1998)

Mutagen

ethyl methanesulfonate

(Taylor et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdomen

(Abramova et al., 1996)

adult abdomen

(Taylor et al., 1998)

adult thorax

(Taylor et al., 1998)

leg

(Taylor et al., 1998)

pigment cell

(Abramova et al., 1996)

tarsal segment

(Taylor et al., 1998)

thorax

(Abramova et al., 1996)

wing

(Taylor et al., 1998, Abramova et al., 1996)

wing | cell non-autonomous | somatic clone

(Adler et al., 2000)

wing basal cell 1 & wing hair

(Taylor et al., 1998)

wing blade dorsal compartment

(Doyle et al., 2008)

wing hair

(Lee and Adler, 2004, Lee and Adler, 2002)

Detailed Description

Statement

Reference

In contrast to wild-types, no clear wing membrane ridge orientation is apparent in either the anterior or posterior region of the wing of Vang^Tbs42 mutants.

(Doyle et al., 2008)

Show moderate multiple wing hair phenotype.

(Lee and Adler, 2002)

Homozygous Vang^Tbs42 clones in the wing exhibit a non-symmetrical domineering non-autonomy. The polarity defects seen are biased in that cells medial to the clone are more likely to be affected.

(Adler et al., 2000)

Show complete penetrance for the wing hair swirl phenotype. Homozygotes show a stronger phenotype than hemizygotes. Phenotype is stronger at 29^oC than at 18^oC. Phenotype falls between that of the fz-like and in-like classes of phenotype. Clonal analysis with Vang^Tbs42 reveals that Vang acts cell nonautonomously, and shows domineering nonautonomy.

(Taylor et al., 1998)

Homozygous flies have polarity disruption in the wing, thorax, eyes and abdomen. Heterozygous flies have polarity disruption in the C-region of the wing.

(Abramova et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Vang^Tbs42 has abnormal planar polarity phenotype, enhanceable by grh^FK2131

(Lee and Adler, 2004)

Enhancer of

Statement

Reference

Vang^Tbs42 is an enhancer of abnormal planar polarity phenotype of grh^FK2131

(Lee and Adler, 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Vang^Tbs42 has wing hair phenotype, enhanceable by grh^FK2131

(Lee and Adler, 2004)

Vang^Tbs42 has wing hair phenotype, enhanceable by in^II53

(Lee and Adler, 2002)

Vang^Tbs42 has phenotype, enhanceable by fz²³

(Taylor et al., 1998)

Vang^Tbs42 has wing basal cell 1 phenotype, enhanceable by fz[+]/fz³⁰

(Taylor et al., 1998)

Suppressed by

Statement

Reference

Vang^Tbs42 has phenotype, suppressible by fz³⁰

(Taylor et al., 1998)

Vang^Tbs42 has phenotype, suppressible by pk^JJ13

(Taylor et al., 1998)

Vang^Tbs42 has wing hair phenotype, suppressible by pk¹

(Taylor et al., 1998)

Vang^Tbs42 has wing hair phenotype, suppressible by fz²⁵

(Taylor et al., 1998)

Enhancer of

Statement

Reference

Vang^Tbs42 is an enhancer of wing hair phenotype of sha^VB13

(Ren et al., 2006)

Vang^Tbs42 is an enhancer of wing hair phenotype of grh^FK2131

(Lee and Adler, 2004)

Vang^Tbs42 is an enhancer of wing hair & 1st posterior cell phenotype of in^II53

(Lee and Adler, 2002)

Vang^Tbs42 is an enhancer of phenotype of fz²⁴

(Taylor et al., 1998)

Other

Statement

Reference

Vang^Tbs42, fz¹ has wing hair phenotype

(Taylor et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The combination of grh^FK2131/+ and Vang^Tbs42 produces tissue polarity defects in the wing over a much larger fraction of the wing than do the single mutants alone.

(Lee and Adler, 2004)

Double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with fz²⁴, dsh¹ in^unspecified and mwh^unspecified all showed hair polarity pattern typical of the fz-in group. Vang is epistatic to pk; double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with pk¹ show a fz-in group phenotype, possible less severe than for the Vang single mutant. Dominant wing basal cell 1 swirl phenotype shows no interaction with dsh, in, fy, frtz, stan or mwh mutants, nor with deficiencies for wg, Wnt2, Wnt4 or Wnt5. Vang^A3 and Vang^Tbs42, but not Vang^11-3 act as dominant enhancers of the dominant phenotype of Df(2R)pk78s. Vang^Tbs42, pk¹ double mutants show an increase in multiple wing hair cells over either single mutant. Vang^Tbs42 is a strong dominant enhancer of fz²⁴. In double mutant combinations between Vang^A3, Vang^A5 and Vang^Tbs42 with fz¹, fz²⁵ and fz³⁰, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant. The domineering nonautonomy of Vang^Tbs42 clones can be suppressed by fz²⁵ and fz³⁰.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Vang^11-3

(Taylor et al., 1998)

Vang^14-11

(Taylor et al., 1998)

Vang⁴⁰⁴¹

(Taylor et al., 1998)

Vang^A3

(Taylor et al., 1998)

Vang^A5

(Taylor et al., 1998)

Vang^XG41

(Taylor et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Vang^TBS42

(Doyle et al., 2008, Chung et al., 2007, Ren et al., 2006, Lee and Adler, 2004, Lee and Adler, 2002, Adler et al., 2000, Taylor et al., 1998)

Vang^Tbs42

vang^TBS42

(Lu et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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