FlyBase Allele Report: Dmel\fz[24]

General Information

Symbol

Dmel\fz²⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0004940

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^R53

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Adler et al., 1998, Taylor et al., 1998, Jones et al., 1996, Krasnow et al., 1995, Krasnow and Adler, 1994)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Amino acid replacement: A374G.

(Povelones et al., 2005)

Amino acid replacement: A374G. Nucleotide substitution: A for G.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,317,244..14,317,244 [+]

Nucleotide change:

G14317244A

Reported nucleotide change:

G?A

Amino acid change:

A374T | fz-PA; A374T | fz-PC

Reported amino acid change:

A374G

Comment:

The reported amino acid substitution (Ala to Gly) is not consistent with the reported nucleotide substitution (GCG to ACG). The curator corrected the amino acid substitution to reflect the reported nucleotide sequence change.

(Povelones et al., 2005, Jones et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Lee and Adler, 2004, Taylor et al., 1998)

visible

visible (with fz³⁰)

(Povelones et al., 2005)

visible | recessive

(Adler et al., 1998)

Phenotype Manifest In

macrochaeta & adult thorax

wing

(Adler et al., 1998, Jones et al., 1996)

wing hair

(Lee and Adler, 2004, Taylor et al., 1998, Krasnow et al., 1995)

wing hair | increased number (with fz³⁰)

(Povelones et al., 2005)

Detailed Description

Statement

Reference

fz²⁴ has a weak multiple wing hair phenotype in combination with fz³⁰.

(Povelones et al., 2005)

Non-autonomous phenotype in wing clones.

(Jones et al., 1996)

Homozygotes exhibit a weak multiple hair cell (MHC) phenotype. Reduction of dsh⁺ gene dosage results in dramatic enhancement of the MHC phenotype and an increase in gene dosage suppresses the phenotype.

(Krasnow et al., 1995)

Weak allele.

(Wong and Adler, 1993)

Moderate thoracic bristle phenotype; moderate wing-hair disorientation. eye texture normal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz²⁴ has abnormal planar polarity phenotype, enhanceable by grh^FK2131/grh[+]

(Lee and Adler, 2004)

Enhancer of

Statement

Reference

fz²⁴ is an enhancer of abnormal planar polarity phenotype of grh^FK2131

(Lee and Adler, 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz²⁴ has wing hair phenotype, enhanceable by grh^FK2131/grh[+]

(Lee and Adler, 2004)

fz²⁴ has phenotype, enhanceable by ds^33k/ds¹

(Adler et al., 1998)

fz²⁴ has phenotype, enhanceable by ds¹

(Adler et al., 1998)

fz²⁴ has phenotype, enhanceable by ds^33k

(Adler et al., 1998)

fz²⁴ has phenotype, enhanceable by Vang^A3

(Taylor et al., 1998)

fz²⁴ has phenotype, enhanceable by Vang^Tbs42

(Taylor et al., 1998)

Enhancer of

Statement

Reference

fz²⁴ is an enhancer of wing hair phenotype of grh^FK2131

(Lee and Adler, 2004)

fz²⁴ is an enhancer of wing hair & 1st posterior cell phenotype of in^II53

(Lee and Adler, 2002)

fz²⁴ is an enhancer of wing hair phenotype of fy⁵

(Lee and Adler, 2002)

fz²⁴ is an enhancer of wing hair phenotype of fy⁶

(Lee and Adler, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The combination of grh^FK2131/+ and fz²⁴ produces tissue polarity defects in the wing over a much larger fraction of the wing than do the single mutants alone.

(Lee and Adler, 2004)

The fraction of the wing that shows abnormal polarity in fz²⁴ flies is increased if the fly also carries ds¹/ds^33k.

(Adler et al., 1998)

Double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with fz²⁴, dsh¹ in^unspecified and mwh^unspecified all showed hair polarity pattern typical of the fz-in group.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

fz^tow

(Chung et al., 2007)

Rescued by

fz²⁴ is rescued by fz^I.hs

(Krasnow and Adler, 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

R53

(Wong and Adler, 1993)

fz²⁴

fz^R53

(Chung et al., 2007, Povelones et al., 2005, Lee and Adler, 2004, Lee and Adler, 2002, Adler et al., 1998, Taylor et al., 1998, Jones et al., 1996, Krasnow et al., 1995, Krasnow and Adler, 1994)

Name Synonyms

Secondary FlyBase IDs

References (11)

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