FB2024_03 , released June 25, 2024
Allele: Dmel\VangA5
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General Information
Symbol
Dmel\VangA5
Species
D. melanogaster
Name
FlyBase ID
FBal0093182
Feature type
allele
Associated gene
Dmel\Vang
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Taylor et al., 1998)

hypomorphic allele - genetic evidence

(Taylor et al., 1998)
Mutagen
gamma ray
(Taylor et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Phenotype is stronger at 29oC than at 18oC. Considered to be antimorphic for the dominant basal cell phenotype, but hemizygotes show a weaker phenotype than for VangA3 hemizygotes, indicating that VangA5 is hypomorphic for the recessive wing hair polarity phenotype. Phenotype falls between that of the fz-like and in-like classes of phenotype.

      (Taylor et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      VangA5 has phenotype, enhanceable by Df(3L)fz-D21

      (Taylor et al., 1998)
      Other
      Statement
      Reference

      VangA5, fz1 has wing hair phenotype

      (Taylor et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutants of VangTbs42, VangA3 or VangA5 with fz24, dsh1 inunspecified and mwhunspecified all showed hair polarity pattern typical of the fz-in group. Vang is epistatic to pk; double mutants of VangTbs42, VangA3 or VangA5 with pk1 show a fz-in group phenotype, possible less severe than for the Vang single mutant. In double mutant combinations between VangA3, VangA5 and VangTbs42 with fz1, fz25 and fz30, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant.

      (Taylor et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      VangTbs42

      (Taylor et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      VangA5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)