FB2024_03 , released June 25, 2024
Allele: Dmel\f1
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General Information
Symbol
Dmel\f1
Species
D. melanogaster
Name
FlyBase ID
FBal0003944
Feature type
allele
Associated gene
Dmel\f
Associated Insertion(s)
gypsy{}f-1
Carried in Construct
Also Known As
f
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Hoover et al., 1993)
Progenitor genotype
Associated Insertion(s)
gypsy{}f-1
Cytology
Description

Insertion of a gypsy element within an intron of the characterised transcripts at nucleotide 15673 in the same orientation as the f gene.

(Hoover et al., 1993)

Single gypsy insert in the second intron at a site identical to the gypsy insert of fX.

(Ishimaru and Saigo, 1993)

Insertion of gypsy 150bp upstream of that in fK, and in the same orientation as that in fK.

(Hoover et al., 1992)

Insertion of gypsy element.

(Georgiev and Gerasimova, 1989)

gypsy insertion.

(Rabinow and Birchler, 1989)

A member of the right hand group of alleles. Contains a gypsy insert in a 3.8 kb EcoRI restriction fragment (Parkhurst and Corces, 1985) and 3.2 kb from a particular SalI restriction site (McLachlan, 1986). Orientation of gypsy element opposite that of the gene.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autosomal recessive nonsyndromic deafness 36
      CEA
      (Cosetti et al., 2008)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fA homozygotes and fA/f1 transheterozygotes exhibit a fork-bristle phenotype.

      (Guida et al., 2016)

      Compared to controls, homozygous mutants show a reduced response to an auditory stimulus mimicking flies' courtship song.

      (Cosetti et al., 2008)

      Larvae exhibit a weak bristle phenotype within the denticles of all rows.

      (Dickinson and Thatcher, 1997)

      The f1 phenotype is not suppressed in flies carrying su(Hw)wt or su(Hw)Δ656-705 in a su(Hw)7/su(Hw)V background, partly suppressed in flies carrying su(Hw)Δ706-736, su(Hw)Δ673-943, su(Hw)Δ853-880 or su(Hw)Δ881-944 in a su(Hw)7/su(Hw)V background, and strongly or completely suppressed in flies carrying su(Hw)Δ2-203.673-943, su(Hw)Δ738-780, su(Hw)Δ2-203 or su(Hw)Δ782-944 in a su(Hw)7/su(Hw)V background.

      (Kim et al., 1996)

      Mild f bristle phenotype. Bristle phenotype is under the control of a second site modifier.

      (Hoover et al., 1993)

      Flies have forked bristles. Phenotype is unaffected by mod(mdg4)ul.

      (Georgiev and Gerasimova, 1989)

      Phenotype is not affected by DoaHD or Doa6.

      (Rabinow and Birchler, 1989)

      f53a13/f1 females have a very slight forked phenotype.

      (Lefevre, 1953)

      moderate - moderate with both macrochaetae and microchaetae clearly affected suppressed by su(f) suppressed by su(Hw)2

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      f1, m1 has viable phenotype

      (Bejsovec and Chao, 2012)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      f1 has phenotype, enhanceable by E(f)1

      Suppressed by
      Statement
      Reference

      f1 has phenotype, suppressible by su(f)4

      (Simonelig et al., 1996, Schalet and Lefevre, 1973, Schalet, 1972)

      f1 has phenotype, suppressible by su(f)8

      (Simonelig et al., 1996)

      f1 has phenotype, suppressible by su(f)12

      (Simonelig et al., 1996)

      f1 has phenotype, suppressible by su(f)13

      (Simonelig et al., 1996)

      f1 has phenotype, suppressible by su(f)14

      (Simonelig et al., 1996)

      f1 has phenotype, suppressible by su(f)27

      (Mitchelson et al., 1993)

      f1 has phenotype, suppressible by su(f)28

      (Mitchelson et al., 1993)

      f1 has phenotype, suppressible by su(Hw)V/su(Hw)V

      (Hoover et al., 1992)

      f1 has phenotype, suppressible by su(f)1

      (Schalet and Lefevre, 1973, Schalet, 1972)

      f1 has phenotype, suppressible by su(f)2

      (Schalet and Lefevre, 1973, Schalet, 1972)

      f1 has phenotype, suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Other
      Statement
      Reference

      ckKT9, f1 has denticle phenotype

      (Bejsovec and Chao, 2012)

      ckKT9, f1, m1 has denticle phenotype

      (Bejsovec and Chao, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      f1 ; ckKT9 double mutants show a slight reduction in both size and sharpness of the denticles compared to either single mutant.

      m1 f1 ckKT9 triple mutants show almost no elongation of the denticles.

      (Bejsovec and Chao, 2012)

      Phenotype is suppressed by a number of su(f) alleles. Strength of suppression of the f1 phenotype: su(f)1 > su(f)4 > su(f)12 > su(f)8.

      (Fitch et al., 1992)

      f1 su(f)4 males and females are f+ at 17-18oC. f1 su(f)4/f1 su(f)1 females are f+, like f1 su(f)1/f1 su(f)1, at all temperatures. f1 su(f)2/f1 su(f)1 females are f+ at 24-25oC. f1 su(f)2/f5 su(f)1 females show suppression of the f mutant phenotype similar to that seen in f1 su(f)1/f5 su(f)1 females at 24-25oC. At 20-30oC, the f1 su(f)2/f5 su(f)1 combination shows suppression of the f mutant phenotype but bristles are Minute-like.

      (Schalet, 1972)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (1)
      Stocks (811)
      Notes on Origin
      Discoverer

      Bridges, 19th Nov. 1912.

      Comments
      Comments

      Synonymy presumed (in FBrf0066905).

      (Dudick et al., 1974)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (38)