FlyBase Allele Report: Dmel\m[1]

General Information

Symbol

Dmel\m¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011837

Feature type

allele

Associated gene

Dmel\m

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Chanut-Delalande et al., 2006, Roch et al., 2003)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Deletion of 33 nucleotides associated with an insertion of 13 nucleotides, 370 amino acids downstream from the start of translation. This causes a frameshift mutation and premature stop codon within the coding region.

(Roch et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

X:11,767,649..11,767,759 [+]

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement: Deletion of 33 nucleotides associated with an insertion of 13 nucleotides, 370 amino acids downstream from the start of translation. Leads to premature stop codon.

(Roch et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage

(Kandasamy et al., 2021)

viable

(Bejsovec and Chao, 2012)

visible | adult stage

(Kandasamy et al., 2021)

Phenotype Manifest In

denticle

(Bejsovec and Chao, 2012, Fernandes et al., 2010, Chanut-Delalande et al., 2006)

oviprovector scale

(Tanaka et al., 2022)

wing

(Kandasamy et al., 2021, Fernandes et al., 2010)

Detailed Description

Statement

Reference

m¹ hemizygotes show a small wing phenotype.

(Kandasamy et al., 2021)

Mutant larvae have thick, broad denticles.

(Bejsovec and Chao, 2012)

Each denticle row is present, but the denticles themselves are small and lack the median constriction, adopting an abnormal triangular shape.

Mutants show a strong reduction in the size of adult wings.

m¹ embryos have impaired contacts between the denticle membrane and cuticle layers

(Fernandes et al., 2010)

m¹ larvae have small, misshapen denticles that display an aberrant triangular shape. Additionally, the denticle cells do not contact cuticle correctly.

(Chanut-Delalande et al., 2006)

m⁶⁸/m¹ females have a m mutant phenotype and are fertile.

(Kaufman, 1969)

m¹/In(1)m^K females may or may not show the m mutant phenotype, some being normal or almost wild-type.

(Krivshenko, 1956)

Wing size reduced, only slightly longer than abdomen and with normal proportions. Angle between L2 and L5 reduced. Wings dark gray and less transparent than normal. Wing cells smaller than normal (Dobzhansky, 1929). In poor cultures, wings may become divergent and stringy. Cell expansion inhibited in prepupae and pupae [Waddington, 1940). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

m¹ has visible | adult stage phenotype, enhanceable by Yif1^doc-1/Yif1[+]

(Kandasamy et al., 2021)

m¹ has decreased size | adult stage phenotype, enhanceable by Yif1^doc-1/Yif1[+]

(Kandasamy et al., 2021)

m¹ has visible | adult stage phenotype, enhanceable by Yif1^doc-99/Yif1[+]

(Kandasamy et al., 2021)

m¹ has visible | adult stage phenotype, enhanceable by Yif1^doc-16/Yif1[+]

(Kandasamy et al., 2021)

m¹ has decreased size | adult stage phenotype, enhanceable by Yif1^doc-16/Yif1[+]

(Kandasamy et al., 2021)

NOT Enhancer of

Statement

Reference

m¹ is a non-enhancer of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

m¹ is a non-suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Other

Statement

Reference

f¹, m¹ has viable phenotype

(Bejsovec and Chao, 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

m¹ has wing phenotype, enhanceable by Yif1^doc-1/Yif1[+]

(Kandasamy et al., 2021)

m¹ has wing phenotype, enhanceable by Yif1^doc-99/Yif1[+]

(Kandasamy et al., 2021)

m¹ has wing phenotype, enhanceable by Yif1^doc-16/Yif1[+]

(Kandasamy et al., 2021)

m¹ has denticle phenotype, enhanceable by sn³

(Chanut-Delalande et al., 2006)

m¹ has denticle phenotype, enhanceable by f^36a

(Chanut-Delalande et al., 2006)

f^36a, m¹ has denticle phenotype, enhanceable by sn³

(Chanut-Delalande et al., 2006)

m¹, sn³ has denticle phenotype, enhanceable by f^36a

(Chanut-Delalande et al., 2006)

f^36a, m¹, sn³ has denticle phenotype, enhanceable by sha^V15

(Chanut-Delalande et al., 2006)

f^36a, m¹, sn³ has larval abdominal dorsal trichome phenotype, enhanceable by sha^V15

(Chanut-Delalande et al., 2006)

f^36a, m¹, sn³ has denticle phenotype, enhanceable by WASp³

(Chanut-Delalande et al., 2006)

f^36a, m¹, sn³ has larval abdominal dorsal trichome phenotype, enhanceable by WASp³

(Chanut-Delalande et al., 2006)

Suppressed by

Statement

Reference

m¹ has denticle phenotype, suppressible by m::tyn^PAN-tyn.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, suppressible by m::tyn^PAN-tyn.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, suppressible | partially by m::tyn^ZPtyn.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, suppressible by m::tyn^ZPm.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

NOT suppressed by

Statement

Reference

m¹ has wing phenotype, non-suppressible by dyl^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, non-suppressible by zye^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, non-suppressible by neo^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, non-suppressible by nyo^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, non-suppressible by tyn^ΔPAN.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by Scer\GAL4^da.G32/tyn^UAS.cFa

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by zye^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by neo^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by nyo^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by tyn^ΔPAN.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has denticle phenotype, non-suppressible by m::tyn^ZPtyn.UAS/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ has wing phenotype, non-suppressible by Scer\GAL4^da.G32/tyn^UAS.cFa

(Fernandes et al., 2010)

m¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

m¹ is an enhancer of denticle phenotype of sn³

(Chanut-Delalande et al., 2006)

m¹ is an enhancer of denticle phenotype of f^36a

(Chanut-Delalande et al., 2006)

NOT Enhancer of

Statement

Reference

m¹ is a non-enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

NOT Suppressor of

Statement

Reference

m¹ is a non-suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

Other

Statement

Reference

ck^KT9, f¹, m¹ has denticle phenotype

(Bejsovec and Chao, 2012)

ck^KT9, m¹ has denticle phenotype

(Bejsovec and Chao, 2012)

m¹, tyn^PG38 has denticle phenotype

(Fernandes et al., 2010)

Df(3L)zye^ex72, m¹, tyn^PG38 has denticle phenotype

(Fernandes et al., 2010)

Scer\GAL4^da.G32, dyl^UAS.cFa, m¹ has denticle phenotype

(Fernandes et al., 2010)

Scer\GAL4^da.G32, m::tyn^ZPm.UAS, m¹ has denticle phenotype

(Fernandes et al., 2010)

f^36a, m¹, sn³ has larval abdominal dorsal trichome phenotype

(Chanut-Delalande et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

m¹ ; ck^KT9 double mutants show a reduction in both size and sharpness of the denticles compared to either single mutant.

m¹ f¹ ck^KT9 triple mutants show almost no elongation of the denticles.

(Bejsovec and Chao, 2012)

m¹, tyn^PG38 double mutants have denticles with thin extremities (as found in tyn^PG38 single mutants) and lacking the medial constriction (as found in m¹ single mutants). The addition of Df(3L)zye^ex72, which deletes zye, has a further effect, leading to denticles with a twisted appearence.

Expression of dyl^Scer\UAS.cFa with Scer\GAL4^da.G32 slightly modifies the m¹ denticle phenotype, but doesn't rescue m¹ the adult wing phenotype.

Expression of m::tyn^{PAN-tyn.Scer\UAS} with Scer\GAL4^da.G32 rescues the m¹ denticle phenotype and the m¹ adult wing phenotype.

Expression of m::tyn^{ZPtyn.Scer\UAS} with Scer\GAL4^da.G32 fails to rescue the m¹ denticle phenotype and only partially restores the m¹ adult wing phenotype.

Expression of m::tyn^ZPm.Scer\UAS with Scer\GAL4^da.G32 has a weak effect on the m¹ denticle phenotype and significantly rescues the m¹ adult wing phenotype.

(Fernandes et al., 2010)

The denticles of m¹, sn³ mutants show splitting in addition to the defects seen in either single mutant. m¹, f^36a mutants also show denticle splitting. sn³, m¹, f^36a triple mutants have small, highly misshapen denticles that are more affected than those of m¹, f^36a or m¹, sn³ double mutants. sn³, m¹, f^36a; sha^V15 and sn³, m¹, f^36a; WASp³ quadruple mutants show further impairment to denticle formation compared to sn³, m¹, f^36a triple mutants, with mutants exhibiting regions of naked cuticle where denticles lie in wild-type animals.

The dorsal hairs on the abdominal segments of sn³, m¹, f^36a triple mutants are severly reduced in size, and in some cases, hairs are abrogated leaving abnormal naked regions. This phenotype is more severe in sn³, m¹, f^36a; WASp³ quadruple mutants and is even more severe in sn³, m¹, f^36a; sha^V15 mutants in which most dorsal hairs are absent, leaving naked cuticle.

(Chanut-Delalande et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

m¹ is rescued by m^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ is rescued by m^UAS.HRP/Scer\GAL4^da.G32

(Fernandes et al., 2010)

m¹ is rescued by m^UAS.cFa/Scer\GAL4^da.G32

(Fernandes et al., 2010)

Not rescued by

m¹ is not rescued by Scer\GAL4^da.G32/m^UAS.tecta

(Fernandes et al., 2010)

Comments

Expression of m^Scer\UAS.cFa or m^{Scer\UAS.T:Arus\HRP} using Scer\GAL4^da.G32 rescues the denticle and adult wing size phenotypes of m¹ animals.

(Fernandes et al., 2010)

Expression of m^Scer\UAS.cFa using Scer\GAL4^da.G32 rescues the denticle defects of m¹ embryos and the reduction in wing size of m¹ adults.

(Fernandes et al., 2010)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (31)

Bloomington

m¹

ras³ m¹

147

w¹ sn³ m¹

963

Df(1)KA10, sn³ m¹/FM7c

1492

w¹ m¹ f¹/FM7c

4657

l(1)2Cc² sn³ m¹ g¹/FM7a

4668

l(1)3Da⁵ sn³ m¹ g¹/FM7a

Kyoto

105713

m¹

101200

w¹ m¹ f¹

106346

w¹ m¹ f¹

105758

w¹ sn³ m¹

106145

Df(1)KA10, sn³ m¹/FM7c

More stocks available...

Notes on Origin

Discoverer

Morgan, Aug. 1910.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Kaufman, 1969, Krivshenko, 1956)

m¹

(Tanaka et al., 2022, Kandasamy et al., 2021, Chanut-Delalande et al., 2014, Bejsovec and Chao, 2012, Cook et al., 2010.5.7, Fernandes et al., 2010, Fernandes et al., 2010, Popodi et al., 2010-, Christensen et al., 2008.6.11, Buff et al., 2007, Chanut-Delalande et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (18)

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