FlyBase Allele Report: Dmel\da[1]

General Information

Symbol

Dmel\da¹

Species

D. melanogaster

Name

FlyBase ID

FBal0002214

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

1360{}da¹

Carried in Construct

Key Links

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

heat sensitive hypomorphic allele - genetic evidence

(Keyes et al., 1992)

Mutagen

spontaneous

(Bell, 1954)

Progenitor genotype

Associated Insertion(s)

1360{}da¹

Cytology

Description

Insertion of a 1360 element.

(Cronmiller, 2002.2.26)

900 bp insertion of middle repetitive DNA in untranslated leader.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with da²)

(Cummings and Cronmiller, 1994)

lethal | female limited | maternal effect (with da^k08611)

(Bloomington Drosophila Stock Center, 2014.8.18)

lethal | heat sensitive

(Castanon et al., 2001)

lethal | maternal effect | heat sensitive

(Keyes et al., 1992)

Phenotype Manifest In

embryonic/larval heart

(Castanon et al., 2001)

embryonic/larval somatic muscle cell

(Castanon et al., 2001)

mesoderm

(Castanon et al., 2001)

Detailed Description

Statement

Reference

Only male progeny are recovered from da¹/da^k08611 females.

(Bloomington Drosophila Stock Center, 2014.8.18)

Homozygotes survive at 18^oC and die at 25^oC. da¹ homozygous embryos lacking maternal and zygotic da have defects in mesodermal development. The mesoderm migrates properly, however, further mesodermal development is impaired. Somatic muscle development is severely suppressed, embryos have reduced numbers of aberrantly placed syncitial muscles. Heart development is also repressed.

(Castanon et al., 2001)

Does not interact with Sxl^dlf, fl(1)35³⁵ or fl(1)35⁴⁶.

(Anand et al., 1998)

Homozygous females have no female offspring due to failure to properly regulate the Sxl gene in the zygote.

(Estes et al., 1995)

At the restrictive temperature (25^oC) less than 1% of females derived from homozygous mothers eclose. At the permissive temperature (18^oC) the viability of these females derived from homozygous mothers is 100%.

(Bopp et al., 1991)

Sxl^f1 heterozygous female progeny derived from heterozygous da¹ mothers have reduced viability. The viability is increased if the Sxl^f1/+ progeny are also carrying msl-3¹, and is decreased if the da¹/+ mothers are also carrying msl-3¹. The frequency of sex transformation in Sxl^f1/+ female progeny derived from da¹/+ mothers is increased if either the mothers or the progeny are homozygous for msl-3¹. The frequency of morphological abnormalities seen in Sxl^f1/+ female progeny derived from da¹/+ mothers is greatly reduced if the progeny are also homozygous for msl-3¹.

(Uenoyama, 1984)

Homozygous females when mated to any male produce normal sons but no daughters. Otherwise, da mutant cannot be distinguished from wild type.

(Bell, 1954)

(=da); viable; temperature-sensitive hypomorph; strong daughterless maternal effect above 22^oC; lethal with Df or amorphic alleles; lethal at 29^oC

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

da¹ has lethal | female phenotype, suppressible by dpn[+]/dpn³

(Barbash and Cline, 1995)

da¹ has lethal | female phenotype, suppressible by dpn[+]/dpn⁴

(Barbash and Cline, 1995)

da¹ has lethal | female phenotype, suppressible by dpn⁵/dpn[+]

(Barbash and Cline, 1995)

da¹ has lethal | female phenotype, suppressible by dpn[+]/dpn⁶

(Barbash and Cline, 1995)

da¹ has lethal | female phenotype, suppressible by dpn⁷/dpn[+]

(Barbash and Cline, 1995)

Phenotype Manifest In

Enhanced by

Statement

Reference

da¹ has phenotype, enhanceable by E(da)¹

(Cline, 1980, Mange and Sandler, 1973)

Enhancer of

Statement

Reference

da¹/da[+] is an enhancer of eye | heat sensitive phenotype of Df(3R)p13/ato¹⁰⁹⁰

(Melicharek et al., 2008)

da¹/da[+] is an enhancer of photoreceptor neuron | heat sensitive phenotype of Df(3R)p13/ato¹⁰⁹⁰

(Melicharek et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

A da¹ heterozygous background gives a dominant moderate enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

(Melicharek et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

da^IB21

(Melicharek et al., 2008)

da^AB12

(Melicharek et al., 2008)

Comments

Lethality of da²/da¹ can be rescued by da^hs.PSP, and females show same follicular phenotype as da^s22/da⁷.

(Cummings and Cronmiller, 1994)

Images (0)

Mutant

Wild-type

Stocks (3)

273

105825

101421

da¹ abo¹ / In(2L)Cy, In(2R)Cy, Duox^Cy cn²

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Uenoyama, 1984)

da¹

(Sandler et al., 2018, Bloomington Drosophila Stock Center, 2014.8.18, Herrero et al., 2014, Kuzin et al., 2011, Benito-Sipos et al., 2010, Johnson et al., 2010, Salzer et al., 2010, González et al., 2008, Melicharek et al., 2008, Christensen and Cook, 2007.10.29, Christensen and Cook, 2006.8.30)

Name Synonyms

Secondary FlyBase IDs

References (35)

Report Sections

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