FB2024_03 , released June 25, 2024
Allele: Dmel\dpn5
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General Information
Symbol
Dmel\dpn5
Species
D. melanogaster
Name
FlyBase ID
FBal0049431
Feature type
allele
Associated gene
Dmel\dpn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Barbash and Cline, 1995)
Mutagen
gamma ray
(Barbash and Cline, 1995)
Progenitor genotype
Cytology
Description

Insertion of 6.5kb between an NaeI site at nucleotide 1309 (amino acid 346) and a BamHI site at nucleotide 1358 (amino acid 363). Resulting protein is predicted to contain the entire bHLH region but be missing 72-89 residues at the C-terminus including the conserved WRPW motif.

(Barbash and Cline, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
2R:8,229,660..8,229,661 [-]
Linked to:
NaeI-BamHI restriction fragment
Comment:

The insertion site of a 6.5kb insertion was mapped to a NaeI-BamHI fragment. The insertion site was approximately annotated to the middle of the restriction fragment by a FlyBase curator.

(Barbash and Cline, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      dpn5/dpn[+] is a suppressor of lethal | female phenotype of da1

      (Barbash and Cline, 1995)

      dpn5/dpn[+] is a suppressor of lethal | female phenotype of scsisB-1

      (Barbash and Cline, 1995)

      dpn5/dpn[+] is a suppressor of lethal | female phenotype of sisA1

      (Barbash and Cline, 1995)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complementation between mutant dpn alleles reveals differences in strength but little male-specific lethality.

      (Barbash and Cline, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dpn5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)