FlyBase Allele Report: Dmel\ato[1090]

General Information

Symbol

Dmel\ato¹⁰⁹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0267206

Feature type

allele

Associated gene

Dmel\ato

Associated Insertion(s)

Carried in Construct

Also Known As

ato^ts

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Melicharek et al., 2008)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye (with ato¹)

(Melicharek et al., 2008)

eye (with ato³)

(Melicharek et al., 2008)

eye | heat sensitive (with ato¹)

(Distefano et al., 2012)

eye | heat sensitive (with Df(3R)p13)

(Melicharek et al., 2008)

photoreceptor neuron | heat sensitive (with Df(3R)p13)

(Melicharek et al., 2008)

Detailed Description

Statement

Reference

ato¹/ato¹⁰⁹⁰ mutants exhibit a small, rough eye phenotype at 25[o]C.

(Distefano et al., 2012)

Heterozygous ato¹⁰⁹⁰ flies show no dominant effect on adult eye morphology at either 18[o] or 29[o]C.

ato¹⁰⁹⁰/Df(3R)p13 flies exhibit severely disrupted eye morphology at 29[o]C, showing loss of nearly all photoreceptors and strongly reduced eye size. When these flies are raised at either 25[o] or 18[o]C, eye size and morphology are strongly rescued, although these eyes still display a rough eye phenotype.

Transheterozygous mutant combinations of ato¹⁰⁹⁰/ato¹ and ato¹⁰⁹⁰/ato³ produce small rough eyes at 25[o]C.

(Melicharek et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

ato¹/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by lilli^AG5/lilli[+]

(Distefano et al., 2012)

ato¹/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by lilli[+]/lilli^GD17

(Distefano et al., 2012)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by hh[+]/hh^AC

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by hh[+]/hh^AC

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by da[+]/da^IB21

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by da[+]/da^IB21

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by da¹/da[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by da¹/da[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by da[+]/da¹⁰

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by da[+]/da¹⁰

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis[+]/kis¹

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis[+]/kis¹

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis^k13416/kis[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis^k13416/kis[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by hh[+]/hh^FS1

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis[+]/kis^EC1

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis[+]/kis^EC1

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis[+]/kis^LM27

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis[+]/kis^LM27

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis[+]/kis^AS21

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis[+]/kis^AS21

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by kis^AO9/kis[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by kis^AO9/kis[+]

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by hh[+]/hh^FS1

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by hh[+]/hh^MM2

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by hh[+]/hh^MM2

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by hh[+]/hh^RM2

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by hh[+]/hh^RM2

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has eye | heat sensitive phenotype, enhanceable by da[+]/da^AB12

(Melicharek et al., 2008)

Df(3R)p13/ato¹⁰⁹⁰ has photoreceptor neuron | heat sensitive phenotype, enhanceable by da[+]/da^AB12

(Melicharek et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

A lilli^GD17 heterozygous background dominantly enhances the ato¹/ato¹⁰⁹⁰ small, rough eye phenotype.

A lilli^AG5 heterozygous background dominantly enhances the ato¹/ato¹⁰⁹⁰ small, rough eye phenotype.

(Distefano et al., 2012)

A hh^AC heterozygous background gives a dominant enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A hh^FS1 heterozygous background gives a dominant enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A hh^MM2 heterozygous background gives a dominant enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A hh^RM2 heterozygous background gives a dominant enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A da^AB12 heterozygous background gives a dominant moderate enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A da^IB21 heterozygous background gives a dominant moderate enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A da¹ heterozygous background gives a dominant moderate enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A da¹⁰ heterozygous background gives a dominant moderate enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis¹ heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis^k13416 heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis^EC1 heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis^LM27 heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis^AS21 heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

A kis^AO9 heterozygous background gives a dominant mild enhancement to the ato¹⁰⁹⁰/Df(3R)p13 eye phenotype at 25[o]C.

(Melicharek et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ato¹⁰⁹⁰

(Distefano et al., 2012, Melicharek et al., 2008)

ato^ts

(Distefano et al., 2012, Melicharek et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close