FB2024_03 , released June 25, 2024
Allele: Dmel\ato3
Open Close
General Information
Symbol
Dmel\ato3
Species
D. melanogaster
Name
FlyBase ID
FBal0042862
Feature type
allele
Associated gene
Dmel\ato
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Jarman et al., 1995)
Mutagen
ethyl methanesulfonate
(Jarman et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q188term.

(Li and Baker, 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,278,687..8,278,687 [+]
Nucleotide change:

C8278687T

Amino acid change:

Q188term | ato-PA

Reported amino acid change:

Q188term

(Li and Baker, 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Transheterozygous ato1090/ato3 mutants produce small rough eyes at 25[o]C.

      (Melicharek et al., 2008)

      Second mitotic wave cells arrest in G2 in small homozygous clones in the eye disc. Mutant cells near the boundary of large clones arrest in G2 but clone interiors do not enter the second mitotic wave.

      (Baker and Yu, 2001)

      Embryos lack almost all chordotonal neurons.

      (Jarman et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      ato3 is an enhancer of visible | dominant phenotype of E(spl)m8-HLH1, Nspl-1

      (Nagel and Preiss, 1999)
      Phenotype Manifest In
      Other
      Statement
      Reference

      ato3/Df(3R)p13, Egfr::toract.UAS, Scer\GAL4bi-omb-Gal4 has eye disc & neuron phenotype

      (Dominguez et al., 1998)

      Egfr::toract.UAS, Scer\GAL4bi-omb-Gal4, ato3 has eye disc & neuron phenotype

      (Dominguez et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Neuronal differentiation is seen in ato3/Df(3R)p13 eye discs expressing Egfr::toract.Scer\UAS under the control of Scer\GAL4bi-omb-Gal4.

      (Dominguez et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ato3
      (Li and Baker, 2018, Melicharek et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)