FlyBase Allele Report: Dmel\ash2[1]

General Information

Symbol

Dmel\ash2¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000757

Feature type

allele

Associated gene

Dmel\ash2

Associated Insertion(s)

Carried in Construct

Also Known As

ash2⁷⁰³

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

N-methyl-N'-nitro-N-nitrosoguanidine

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(LaJeunesse and Shearn, 1995, Shearn, 1989)

Mutagen

N-methyl-N'-nitro-N-nitrosoguanidine

(Adamson and Shearn, 1996, LaJeunesse and Shearn, 1995)

Progenitor genotype

Cytology

Description

3kb insertion.

(Adamson and Shearn, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Type II neuroblasts in homozygous clones in the larval brain adopt a type I neuroblast identity.

(Komori et al., 2014)

Lethality occurs after puparium formation. Mutations elicits a wide range of homeotic transformations: proboscis to leg and/or antenna, antenna to leg, dorsal prothorax to wing, first leg to second leg, haltere to wing, third leg to second leg and genitalia to leg and/or antenna. ash2¹/ash2⁹ transheterozygote third legs display overgrowth and supernumerary leg.

(Adamson and Shearn, 1996)

Lethality acts during the L2/L3 larval instars.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ash2¹⁸/ash2¹ has lethal phenotype, enhanceable by sktl[+]/sktl^Δ15

(Cheng and Shearn, 2004)

NOT Enhancer of

Statement

Reference

ash2[+]/ash2¹ is a non-enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-enhancer of visible | homeotic phenotype of Dsp1¹

(Decoville et al., 2001)

Suppressor of

Statement

Reference

ash2¹ is a suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

ash2[+]/ash2¹ is a non-suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

ash2¹⁸/ash2¹, sktl^Δ15 has abnormal developmental rate phenotype

(Cheng and Shearn, 2004)

ash2¹⁸/ash2¹, sktl[+]/sktl^Δ15 has abnormal developmental rate phenotype

(Cheng and Shearn, 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

ash2¹ is an enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

ash2¹/ash1¹ is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

ash2¹/ash1¹ is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

ash2¹/ash1¹ is an enhancer of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

ash2¹/ash1¹ is an enhancer of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

ash2¹/ash1¹ is an enhancer of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

ash2¹ is an enhancer of phenotype of Antp^Ns

(Adamson and Shearn, 1996)

NOT Enhancer of

Statement

Reference

ash2[+]/ash2¹ is a non-enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-enhancer of haltere phenotype of Dsp1¹

(Decoville et al., 2001)

ash2[+]/ash2¹ is a non-enhancer of wing | ectopic phenotype of Dsp1¹

(Decoville et al., 2001)

ash2¹ is a non-enhancer of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

ash2¹ is a non-enhancer of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

ash2¹ is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, osa^UAS.cCa

(Collins et al., 1999)

Suppressor of

Statement

Reference

ash2¹ is a suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

ash2[+]/ash2¹ is a non-suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

ash2[+]/ash2¹ is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

ash2¹ is a non-suppressor of wing phenotype of Scer\GAL4^OK386, nej^UAS.cMa

(Bantignies et al., 2000)

ash2¹ is a non-suppressor of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

ash2¹ is a non-suppressor of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

ash2¹ is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, osa^UAS.cCa

(Collins et al., 1999)

Other

Statement

Reference

Df(3R)red-P93, ash2¹ has metathoracic leg phenotype

(Shearn, 1989)

Df(3R)red-P93, ash2¹ has haltere phenotype

(Shearn, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is not affected by combination with a single copy of ash2¹.

(Morimoto et al., 2016)

sktl^Δ15/+ ; ash2¹/ash2¹⁸ larvae have delayed development and die at an earlier stage than ash2¹/ash2¹⁸ larvae.

(Cheng and Shearn, 2004)

ash2¹/+ does not significantly enhance the frequency of transformation of halteres into wings seen in Dsp1¹/Y flies.

(Decoville et al., 2001)

The addition of ash2¹ does not effect the variable eye size phenotype seen in osa^Scer\UAS.cCa/Scer\GAL4^ey.PH flies.

(Collins et al., 1999)

Flies heterozygous for both Df(3R)red-P93 and ash2¹ express a weak transformation of halteres to wings or third legs to second legs.

(Shearn, 1989)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is not affected by combination with a single copy of ash2¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

ash2^I1

(Amoros et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4584

red¹ e¹ ash2¹/TM6B, Tb¹

Kyoto

107807

red¹ e¹ ash2¹/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

703

ash-2⁷⁰³

(Shearn, 1989)

ash2¹

(Kim et al., 2023, Voortman et al., 2022, Leatham-Jensen et al., 2019, Komori et al., 2014, Vasanthi et al., 2013, Ji et al., 2012, Christensen et al., 2008.4.15, Vázquez et al., 2008, Chang et al., 2007, Secombe et al., 2007)

ash2⁷⁰³

(Cheng and Shearn, 2004, Adamson and Shearn, 1996)

mad¹

mad⁷⁰³

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

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