FlyBase Allele Report: Dmel\Abd-B[iab9-tuh-3]

General Information

Symbol

Dmel\Abd-B^iab9-tuh-3

Species

D. melanogaster

Name

FlyBase ID

FBal0000142

Feature type

allele

Associated gene

Dmel\Abd-B

Associated Insertion(s)

297{}Abd-B^iab9-tuh-3

Carried in Construct

Also Known As

tuh-3

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

spontaneous

(Kuhn et al., 1995, Kuhn et al., 1993, Karch et al., 1985)

ethyl methanesulfonate

(Kuhn et al., 1993, Bownes et al., 1981)

Progenitor genotype

Associated Insertion(s)

297{}Abd-B^iab9-tuh-3

Cytology

Polytene chromosomes normal.

(Kuhn et al., 1993)

Description

Insertion of 297 element at around coordinate +173kb, in the middle of the first intron of the class B and class C transcripts, and greater than 25kb from the Delta88 insertion in the Abd-B^iab9-tuh-3 chromosome, previously thought to be the cause of the mutant phenotype.

(Mack et al., 1997)

Mutation in the r element.

(Sanchez-Herrero, 1991)

Delta88 element insertion at +200 kb.

(Karch et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Celniker and Lewis, 1987)

some die during larval stage | recessive

(Celniker and Lewis, 1987)

viable

(Sanchez-Herrero and Crosby, 1988)

visible | homeotic | recessive

(Sanchez-Herrero and Crosby, 1988)

visible | recessive

(Kuhn et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

Phenotypically similar to "Abd-B^I127B".

(Mack et al., 1997)

Male and female abdominal segment are normal, genitalia and analia are missing.

(Kuhn et al., 1995)

Enhances penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3. Heterozygotes with Abd-B^iab9-tuh-3 exhibit genital defects to a moderate degree. Adult homozygous males have 6 normal abdominal segments. Males and females lack genitalia. Abd-B^iab9-tuh-3 females deficient for tuh1^h produce offspring with head defects and normal genitalia, just like homozygotes for tuh1^h.

(Kuhn et al., 1993)

Parasegment 14 is partially transformed to parasegment 13.

(Sanchez-Herrero, 1991)

Male and female genitalia and analia are missing or abnormal in homozygotes. Parasegment 14 is partially transformed into parasegment 13, and there is a rudimentary setal belt in A9 in homozygous embryos. Also shows dominant gain-of-function phenotypes.

(Sanchez-Herrero and Crosby, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Abd-B^iab9-tuh-3, tuh1^h has visible | dominant phenotype

(Karch et al., 1985)

Abd-B^iab9-tuh-3, tuh1^h has neoplasia | dominant phenotype

(Karch et al., 1985)

Abd-B^iab9-tuh-3, tuh1^g has visible | recessive phenotype

(Karch et al., 1985, Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has visible | semidominant phenotype

(Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has visible | heat sensitive phenotype

(Bownes et al., 1981)

Phenotype Manifest In

Other

Statement

Reference

Abd-B^iab8-D16/Abd-B^iab9-tuh-3, tuh1^g has male genitalia phenotype

(Mack et al., 1997)

Abd-B^iab9-tuh-3, tuh1^h has embryonic head phenotype

(Mack et al., 1997)

Abd-B^iab9-tuh-3, tuh1^h has genitalia | ectopic phenotype

(Karch et al., 1985, Kuhn et al., 1984, Bownes et al., 1981)

Abd-B^iab9-tuh-3, tuh1^g has genitalia phenotype

(Karch et al., 1985, Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has head phenotype

(Karch et al., 1985, Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has abdomen | ectopic phenotype

(Kuhn et al., 1984)

Abd-B^iab9-tuh-3, tuh1^h has adult head phenotype

(Bownes et al., 1981)

Abd-B^iab9-tuh-3, tuh1^h has eye phenotype

(Bownes et al., 1981)

Additional Comments

Genetic Interactions

Statement

Reference

Mutant phenotype responds to tuh1^h maternal effect by producing head defects, with ectopic posterior abdominal and genital tissue. Mutant phenotype of Abd-B^iab9-tuh-3/Abd-B^iab8-D16 responds to tuh1^g maternal effect by producing genital defects.

(Mack et al., 1997)

Phenotype depends on the allele tuh1 on the X chromosome: in the presence of tuh1^h shows a dominant expression of head tumours composed of genital tissue, in the presence of tuh1^g shows a recessive phenotype and loss of genitalia in both sexes.

(Karch et al., 1985)

Abd-B^iab9-tuh-3 acts as a recessive allele in combination with tuh1^g, causing internal and external genitalia to be deleted. Abd-B^iab9-tuh-3 acts as a semidominant allele in combination with tuh1^h, causing growths of abdominal and/or genital tissue in the head.

(Kuhn et al., 1984)

tuh1^h/tuh1^h Abd-B^iab7-SGA/Abd-B^iab9-tuh-3 flies have a similar phenotype to Abd-B^iab7-SGA heterozygotes.

(Awad et al., 1981)

Abd-B^iab9-tuh-3 flies also homozygous for tuh1^h show eye outgrowths and have a transformation of head structures to genitalia. This phenotype is temperature-sensitive, having increased penetrance at 25 rather than 18^oC.

(Bownes et al., 1981)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Abd-B^iab8-D15

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D14

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv82

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv89

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M7

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M4

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M2

(Sanchez-Herrero and Crosby, 1988)

Abd-B³⁸⁰

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S2

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S1

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M3

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S8

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^R

(Sanchez-Herrero and Crosby, 1988)

Abd-B^F

(Sanchez-Herrero and Crosby, 1988)

Partially complements

Abd-B^iab8-D14

(Kuhn et al., 1993)

Abd-B^UC21

(Kuhn et al., 1993)

Abd-B^S7

(Kuhn et al., 1993)

Abd-B^S4

(Kuhn et al., 1993)

Abd-B^S2

(Kuhn et al., 1993)

Abd-B^S1

(Kuhn et al., 1993)

Abd-B^M3

(Kuhn et al., 1993)

Comments

Complements iab-5 and iab-6 alleles.

(Sanchez-Herrero and Crosby, 1988)

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

674

tuh1^h; Abd-B^iab9-tuh-3

Kyoto

101914

tuh1^h ; Abd-B^iab9-tuh-3

101915

tuh1^h ; Abd-B^iab9-tuh-3

106493

mwh¹ Pc²⁴ Abd-B^iab9-tuh-3/TM3, Sb¹

Notes on Origin

Discoverer

C.M. Woolf.

(Karch et al., 1985)

Comments

"FBti0014081 == 297{}Abd-B^iab9-tuh-3" was stated as revision.

m⁺ r^- mutant.

(Macias et al., 1990)

m⁺ r^- mutant. Of 21 Abd-B alleles tested, Abd-B^iab9-tuh-3 and Abd-B^iab9-tuh-3 were the only ones that required mothers to be homozygous for tuh1^h for head defects to be expressed.

(Kuhn et al., 1993)

Abd-B m⁺ r^- mutation.

(Kuhn et al., 1995)

"FBti0014081 == 297{}Abd-B^iab9-tuh-3" was stated as revision. Recombinant analysis determined the 297 insertion to be responsible for the mutant phenotype, not the Delta88 insert previously described. The 297 molecular lesion in what was previously known as "Abd-B^I127B" is identical to that in stocks traditionally thought of as Abd-B^iab9-tuh-3.

(Mack et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Abd-B^I127B

Abd-B^iab9-tuh-3

Abd-B^tuh-3

(Macias et al., 1990)

I127

(Bownes et al., 1981)

I127^B

(Kuhn et al., 1993)

Tuh-3

(Kuhn et al., 1993)

iab-8^tuh-3

(Sanchez-Herrero and Crosby, 1988)

iab9^tuh-3

tuh-3

(Kuhn et al., 1995, de Lorenzi et al., 1988, Kuhn et al., 1984, Nickla and Carney, 1984, Bownes et al., 1981)

tuh3

(Awad et al., 1981)

Name Synonyms

Secondary FlyBase IDs

FBal0033314

References (14)

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