FlyBase Allele Report: Dmel\Abd-B[iab8-D14]

General Information

Symbol

Dmel\Abd-B^iab8-D14

Species

D. melanogaster

Name

FlyBase ID

FBal0000135

Feature type

allele

Associated gene

Dmel\Abd-B

Associated Insertion(s)

Carried in Construct

Also Known As

Abd-B^D14, D14, iab-7^D14

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Boulet et al., 1991, Celniker et al., 1990)

Mutagen

ethyl methanesulfonate

(Karch et al., 1985)

X ray

(Kuhn et al., 1993)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Hendrickson and Sakonju, 1995)

Description

411bp deletion (from base pair position -66 to +345 of the Abd-B class A promoter and transcription start site, obliterating detectable levels of Abd-B class A transcription.

(Hendrickson and Sakonju, 1995)

Alteration maps to between coordinates +157 and +157.4kb.

(Kuhn et al., 1993)

411 bp deletion extending from -66 bp to +345bp relative to the class A transcription start site.

(Boulet et al., 1991)

Mutation in the m element.

(Sanchez-Herrero, 1991)

396 bp deletion spanning the transcription start site of the P4 promoter region (FBrf0049812).

(Celniker et al., 1990)

411 bp deletion of the Abd-B locus extending from 66 bp upstream to 345 bp downstream of the transcription initiation for class A RNA: inactivates the morphogenetic "m" function of Abd-B.

(Zavortink and Sakonju, 1989)

0.4kb deletion in the region of the opa-e repeat.

(de Lorenzi et al., 1988)

Lesion mapped to: 157-157.4 kb. 0.4kb deletion.

(Karch et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Karch et al., 1985)

female sterile | dominant

(Karch et al., 1985)

lethal | recessive

(Karch et al., 1985)

male sterile

(Karch et al., 1985)

male sterile | dominant

(Karch et al., 1985)

visible | dominant

(Sipos et al., 1998)

visible | homeotic

(Sanchez-Herrero and Crosby, 1988)

visible | homeotic (with Abd-B^Uab-1)

(Chen et al., 2005)

visible | recessive

(Castelli-Gair, 1998)

Phenotype Manifest In

abdominal segment 5

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 6

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 7

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 8

(Sanchez-Herrero and Crosby, 1988)

adult abdominal segment 7

(Sipos et al., 1998)

embryonic/larval posterior spiracle | embryonic stage

(Kuhn et al., 1995)

embryonic abdominal segment 5 (with Abd-B^Uab-1)

(Chen et al., 2005)

embryonic abdominal segment 6 (with Abd-B^Uab-1)

(Chen et al., 2005)

embryonic abdominal segment 7 (with Abd-B^Uab-1)

(Chen et al., 2005)

embryonic abdominal segment 8 (with Abd-B^Uab-1)

(Chen et al., 2005)

embryonic abdominal segment 9 (with Abd-B^Uab-1)

(Chen et al., 2005)

female analia

(Kuhn et al., 1995)

female genitalia

(Kuhn et al., 1995)

female genitalia (with Abd-B^T2N)

(Foronda et al., 2006)

genital disc primordium

(Chen et al., 2005)

genital disc primordium (with Abd-B^Uab-1)

(Chen et al., 2005)

genitalia | female

(Sanchez-Herrero and Crosby, 1988)

head

(Kuhn et al., 1993)

male genitalia (with Abd-B^T2N)

(Foronda et al., 2006)

parasegment 10

(Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

parasegment 11

(Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

parasegment 12

(Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

parasegment 13

(Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

testis (with Abd-B^T2N)

(Foronda et al., 2006)

Detailed Description

Statement

Reference

In Abd-B^iab8-D14/Abd-B^T2N mutant females (mutant for Abd-B m protein), the internal female genitalia do not develop properly and, in some cases, parovaria are the only structures remaining. In males, these mutants do not affect the internal genitalia, although the testes are reduced in size and are not connected properly with the internal genitalia.

(Foronda et al., 2006)

Stage 15 Abd-B^iab8-D14 embryos have only 13 genital disc precursor cells, instead of the wild-type number of 22. In Abd-B^iab8-D14/Abd-B^Uab-1 mutant embryos, segments A5 to A9 are transformed into more anterior-like segments and most genital disc precursor cells are missing, leaving just ~7 present instead of the wild-type number of 22.

(Chen et al., 2005)

An A7 segment forms in Abd-B^M5/Abd-B^iab8-D14 adult males.

(Castelli-Gair, 1998)

Heterozygous males show a weak A7 to A6 transformation.

(Sipos et al., 1998)

Adult females have eight abdominal segments, lack genitalia and (occasionally) analia. Males have eight abdominal segments and retain both genitalia and analia. In these flies parasegment 13 is transformed towards 10 while parasegment 14 is unaffected. Embryos lack posterior spiracles.

(Kuhn et al., 1995)

Partially suppressed by Abd-B^iab9-tuh-3. Reduced penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3.

(Kuhn et al., 1993)

Parasegments 10--13 are transformed to parasegment 9 (FBrf0043917).

(Sanchez-Herrero, 1991)

A5-A8 are transformed to A4, females lack genitalia, and there is a weak haploinsufficient transformation of A5-A8. Parasegments 10-13 are transformed to parasegment 9 in embryos.

(Sanchez-Herrero and Crosby, 1988)

Dominant haplo-insufficient phenotypes, both sexes are partially or completely sterile. Lethal or nearly lethal over Df(3R)P9.

(Karch et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Abd-B^iab8-D14 is a suppressor of ventral mesothoracic disc primordium phenotype of Pc³

(Chen et al., 2005)

Abd-B^iab8-D14 is a suppressor of genital disc primordium | ectopic phenotype of Pc³

(Chen et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic genital disc precursor cells seen in Pc³ single mutant stage 15 embryos are absent in Pc³ Abd-B^iab8-D14 double mutant embryos and the leg disc precursor cells are present.

(Chen et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Abd-B^Sz

(Sipos et al., 1998)

Abd-B^iab9-tuh-3

(Kuhn et al., 1993)

Comments

Abd-B^iab8-D14 weakly complements the iab-7 loss of function mutant Abd-B^Sz in segment A7 in males.

(Sipos et al., 1998)

Fails to complement iab-5 and iab-6 alleles.

(Sanchez-Herrero and Crosby, 1988)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Duncan.

I. Duncan.

(Karch et al., 1985)

Comments

Weak allele.

(Celniker and Lewis, 1987)

Abd-B mRNA and protein are absent from parasegments 10-13 but present at wild type levels in parasegment 14. This confirms that Abd-B^iab8-D14 mutant embryos lack the m mRNA.

(Boulet et al., 1991)

m^- r⁺ mutant, eliminating function of Abd-B function.

(Kuhn et al., 1993)

Genetically null for the Abd-B m function.

(Hendrickson and Sakonju, 1995)

Abd-B m^-r⁺ mutation.

(Kuhn et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

ABD-BI

(Chen et al., 2005)

Abd-B^D14

(Garaulet et al., 2014, Gummalla et al., 2012, Lemons et al., 2012, Foronda et al., 2006, Chen et al., 2005, Duncan, 2002, Estrada et al., 2002, Castelli-Gair, 1998, Sipos et al., 1998, Cimbora and Sakonju, 1995, Hendrickson and Sakonju, 1995, Kuhn et al., 1995, Crosby et al., 1993, Galloni et al., 1993)

Abd-B^iab8-D14

D14

(Kuhn et al., 1993, Celniker et al., 1989, Kuziora and McGinnis, 1988)

Df(3R)D14

(Zavortink and Sakonju, 1989)

iab-7^D14

(de Lorenzi et al., 1988, Sanchez-Herrero and Crosby, 1988)

iab7^D14

iab8^D14

(Celniker and Lewis, 1987)

Name Synonyms

Secondary FlyBase IDs

References (25)

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