FlyBase Allele Report: Dmel\Abd-B[M2]

General Information

Symbol

Dmel\Abd-B^M2

Species

D. melanogaster

Name

FlyBase ID

FBal0028660

Feature type

allele

Associated gene

Dmel\Abd-B

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Celniker et al., 1990, de Lorenzi and Bienz, 1990)

Mutagen

ethyl methanesulfonate

(de Lorenzi and Bienz, 1990, Sanchez-Herrero et al., 1985)

Progenitor genotype

Cytology

Description

Mutation within coding region: eliminate m function.

(de Lorenzi and Bienz, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | homeotic

(Sanchez-Herrero and Crosby, 1988)

Phenotype Manifest In

abdominal segment 5

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 6

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 7

(Sanchez-Herrero and Crosby, 1988)

abdominal segment 8

(Sanchez-Herrero and Crosby, 1988)

abdominal sternite 6 | male limited (with Abd-B^Fab7-1)

(Wang et al., 2011)

adult abdominal segment 7 | ectopic | male limited (with Abd-B^Fab7-1)

(Wang et al., 2011)

dMP2 neuron | embryonic stage 17 (with Abd-B^M5)

(Miguel-Aliaga and Thor, 2004)

dMP2 neuron | embryonic stage 17 (with Abd-B^M5), with Abd-B^UAS.cCa, Scer\GAL4^elav-C155

(Miguel-Aliaga and Thor, 2004)

genitalia | female

(Sanchez-Herrero and Crosby, 1988)

larval MP1 neuron | embryonic stage 17 (with Abd-B^M5)

(Miguel-Aliaga and Thor, 2004)

larval MP1 neuron | embryonic stage 17 (with Abd-B^M5), with Abd-B^UAS.cCa, Scer\GAL4^elav-C155

(Miguel-Aliaga and Thor, 2004)

parasegment 10

(Sanchez-Herrero and Crosby, 1988)

parasegment 11

(Sanchez-Herrero and Crosby, 1988)

parasegment 12

(Sanchez-Herrero and Crosby, 1988)

parasegment 13

(Sanchez-Herrero and Crosby, 1988)

Detailed Description

Statement

Reference

An A7-like terminal abdominal segment (similar to abdominal segment 7 found in wild-type females) forms and A6 sternite is transformed toward anterior identity in Abd-B^Fab7-1/Abd-B^M2 trans-heterozygous males.

(Wang et al., 2011)

dMP2 and MP1 neurons appear to be generated throughout the ventral nerve cord in normal numbers in Abd-B^M2/Abd-B^M5 embryos. However, at stage 17, all dMP2 and MP1 neurons (including posterior ones) appear to undergo apoptosis (in wild-type embryos, the anterior dMP2 and MP1 neurons are lost by the late embryonic stage, but posterior dMP2 and MP1 neurons persist). Expression of Abd-B^Scer\UAS.cCa under the control of Scer\GAL4^elav-C155 in late stage Abd-B^M2/Abd-B^M5 embryos results in the suppression of cell death normally seen in anterior dMP2 and MP1 neurons in wild-type late stage embryos.

(Miguel-Aliaga and Thor, 2004)

A5-A8 are transformed to A4, females lack genitalia, and there is a weak haploinsufficient transformation of A5-A8. Parasegments 10-13 are transformed to parasegment 9 in embryos.

(Sanchez-Herrero and Crosby, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions