gel, l(2)06243, l(2)k13638, gelded, l(2)k06338
conserved transmembrane IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size, controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton
Please see the JBrowse view of Dmel\Bsg for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bsg using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Bsg transcript is expressed in the adepithelial cells of the larval eye disc.
Comment: low expression in the fan-shaped body in layers
Comment: low expression throughout adult brain
JBrowse - Visual display of RNA-Seq signals
View Dmel\Bsg in JBrowse2-30
2-26.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Bsg is required within the presynaptic terminal to inhibit non-synchronized evoked vesicle release,
Bsg is part of a transsynaptic complex regulating synaptic compartmentalization and strength, and co-ordinating plasma membrane and cortical organization.
Loss of Bsg function from photoreceptors results in misplacement of nuclei, rough endoplasmic reticulum and mitochondria, as well as swollen axon terminals.
There is conflicting complementation data concerning the Bsg locus and mutations in CG31605. These data indicate complex complementation, which is a likely scenerio given that CG31605 is predicted by Gadfly to produce nine different transcripts and two different proteins.
2 alleles of l(2)SH1217 recovered in a P-insertion screen.
New annotation (CG31605) in release 3 of the genome annotation.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
Postmeiotic differentiation defect.
Source for merge of: gel l(2)06243 l(2)k13638
Source for merge of: gel l(2)k06338 l(2)k09030
Source for merge of: Bsg l(2)SH1217
Source for merge of: gel BcDNA:GH21853
Source for merge of: gel CG31605
l(2)s4199 may correspond to Bsg: the P{lacW}l(2)s4199s4199 insertion maps within the transcription unit.
Source for merge of gel BcDNA:GH21853 was a shared cDNA ( date:030728 ).
"smi28E" may correspond to "gel"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "gel". "smi28E" may correspond to "Bsg"; the P{lArB}smi28E1 insertion is 286bp upstream of the transcription start site of "Bsg".
Source for merge of gel CG31605 was location of gel P-insert alleles inside CG31605 ( date:030408 ).
