DMRTF, mal-d, mal
conserved cofactor for serum response factor - required for border cell migration during oogenesis - activation induced by cell stretching - regulates tracheal branching
Please see the JBrowse view of Dmel\Mrtf for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.54
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.02
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mrtf using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Mrtf in JBrowse3-4
3-5.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Mrtf is required for proper patterning of the tracheal system, for mesodermal cell migration and for the formation of wing intervein tissue.
A substantial open reading frame is present upstream of the ATG codon, but its significance is unclear. There is strong in vivo evidence that the physical state of the cell determines whether Mrtf protein accumulates in the nucleus; slbo mutant border follicle cells, which cannot on their own accumulate nuclear Mrtf protein, can accumulate nuclear Mrtf protein if they are pulled by wild-type cells.
Mrtf is required for migrating border follicle cells to build up a robust cytoskeleton and remain intact during invasive migration.
Source for merge of: CG12188 CG14951
Annotations CG12188 and CG14951 merged as CG32296 in release 3 of the genome annotation.
Source for identity of Mrtf CG32296 was sequence comparison ( date:040830 ).
Source for identity of: Mrtf CG32296